Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the … C Théry, KW Witwer, E Aikawa, MJ Alcaraz, JD Anderson, ... Journal of extracellular vesicles 7 (1), 1535750, 2018 | 8737 | 2018 |
Functional siRNAs and miRNAs exhibit strand bias A Khvorova, A Reynolds, SD Jayasena Cell 115 (2), 209-216, 2003 | 3954 | 2003 |
Rational siRNA design for RNA interference A Reynolds, D Leake, Q Boese, S Scaringe, WS Marshall, A Khvorova Nature biotechnology 22 (3), 326-330, 2004 | 2958 | 2004 |
3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets A Birmingham, EM Anderson, A Reynolds, D Ilsley-Tyree, D Leake, ... Nature methods 3 (3), 199-204, 2006 | 1193 | 2006 |
Position-specific chemical modification of siRNAs reduces “off-target” transcript silencing AL Jackson, J Burchard, D Leake, A Reynolds, J Schelter, J Guo, ... Rna 12 (7), 1197-1205, 2006 | 1065 | 2006 |
The chemical evolution of oligonucleotide therapies of clinical utility A Khvorova, JK Watts Nature biotechnology 35 (3), 238-248, 2017 | 1060 | 2017 |
Functional and hyperfunctional siRNA A Khvorova, A Reynolds, D Leake, W Marshall, S Scaringe US Patent 8,090,542, 2012 | 979 | 2012 |
Identification of the gene for vitamin K epoxide reductase T Li, CY Chang, DY Jin, PJ Lin, A Khvorova, DW Stafford Nature 427 (6974), 541-544, 2004 | 936 | 2004 |
Off-target effects by siRNA can induce toxic phenotype Y Fedorov, EM Anderson, A Birmingham, A Reynolds, J Karpilow, ... Rna 12 (7), 1188-1196, 2006 | 670 | 2006 |
High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources RA Haraszti, MC Didiot, E Sapp, J Leszyk, SA Shaffer, HE Rockwell, ... Journal of extracellular vesicles 5 (1), 32570, 2016 | 646 | 2016 |
Methods and compositions for selecting siRNA of improved functionality A Khvorova, A Reynolds, D Leake, W Marshall, S Read, S Scaringe US Patent App. 10/940,892, 2005 | 567 | 2005 |
Analysis of Clathrin-Mediated Endocytosis of Epidermal Growth Factor Receptor by RNA Interference*[Boxs] F Huang, A Khvorova, W Marshall, A Sorkin Journal of Biological Chemistry 279 (16), 16657-16661, 2004 | 551 | 2004 |
Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity A Khvorova, A Lescoute, E Westhof, SD Jayasena Nature Structural & Molecular Biology 10 (9), 708-712, 2003 | 541 | 2003 |
Functional and hyperfunctional siRNA A Khvorova, A Reynolds, D Leake, W Marshall, S Scaringe, S Read US Patent 7,691,997, 2010 | 519 | 2010 |
Identification of genes that regulate epithelial cell migration using an siRNA screening approach KJ Simpson, LM Selfors, J Bui, A Reynolds, D Leake, A Khvorova, ... Nature cell biology 10 (9), 1027-1038, 2008 | 492 | 2008 |
Exosome-mediated delivery of hydrophobically modified siRNA for huntingtin mRNA silencing MC Didiot, LM Hall, AH Coles, RA Haraszti, BMDC Godinho, K Chase, ... Molecular Therapy 24 (10), 1836-1847, 2016 | 462 | 2016 |
RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells JA Wilson, S Jayasena, A Khvorova, S Sabatinos, IG Rodrigue-Gervais, ... Proceedings of the National Academy of Sciences 100 (5), 2783-2788, 2003 | 455 | 2003 |
Induction of the interferon response by siRNA is cell type–and duplex length–dependent A Reynolds, EM Anderson, A Vermeulen, Y Fedorov, K Robinson, ... Rna 12 (6), 988-993, 2006 | 449 | 2006 |
The contributions of dsRNA structure to Dicer specificity and efficiency A Vermeulen, L Behlen, A Reynolds, A Wolfson, WS Marshall, ... Rna 11 (5), 674-682, 2005 | 405 | 2005 |
A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis BG Lambrus, V Daggubati, Y Uetake, PM Scott, KM Clutario, G Sluder, ... Journal of Cell Biology 214 (2), 143-153, 2016 | 383* | 2016 |