Identification and validation of novel small molecule disruptors of HuR-mRNA interaction X Wu, L Lan, DM Wilson, RT Marquez, W Tsao, P Gao, A Roy, BA Turner, ... ACS chemical biology 10 (6), 1476-1484, 2015 | 154 | 2015 |
Natural product (−)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1 L Lan, C Appelman, AR Smith, J Yu, S Larsen, RT Marquez, H Liu, X Wu, ... Molecular oncology 9 (7), 1406-1420, 2015 | 133 | 2015 |
Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis X Wu, G Gardashova, L Lan, S Han, C Zhong, RT Marquez, L Wei, ... Communications biology 3 (1), 193, 2020 | 83 | 2020 |
Tumor suppressive microRNA-137 negatively regulates Musashi-1 and colorectal cancer progression AR Smith, RT Marquez, WC Tsao, S Pathak, A Roy, J Ping, B Wilkerson, ... Oncotarget 6 (14), 12558, 2015 | 78 | 2015 |
Rab11 maintains connections between germline stem cells and niche cells in the Drosophila ovary N Bogard, L Lan, J Xu, RS Cohen Oxford University Press for The Company of Biologists Limited 134 (19), 3413 …, 2007 | 76 | 2007 |
The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro K Kaur, X Wu, JK Fields, DK Johnson, L Lan, M Pratt, AD Somoza, ... PLoS One 12 (4), e0175471, 2017 | 49 | 2017 |
Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins L Lan, H Liu, AR Smith, C Appelman, J Yu, S Larsen, RT Marquez, X Wu, ... BMC cancer 18, 1-14, 2018 | 43 | 2018 |
Double-layered hyaluronic acid/stearic acid-modified polyethyleneimine nanoparticles encapsulating (−)-gossypol: a nanocarrier for chiral anticancer drugs H Liu, K Li, L Lan, J Ma, Y Zeng, L Xu, D Wu Journal of Materials Chemistry B 2 (32), 5238-5248, 2014 | 41 | 2014 |
MicroRNA‐383 acts as a tumor suppressor in colorectal cancer by modulating CREPT/RPRD1B expression J Li, AR Smith, RT Marquez, J Li, K Li, L Lan, X Wu, L Zhao, F Ren, ... Molecular carcinogenesis 57 (10), 1408-1420, 2018 | 34 | 2018 |
DARC: mapping surface topography by ray-casting for effective virtual screening at protein interaction sites R Gowthaman, SA Miller, S Rogers, J Khowsathit, L Lan, N Bai, ... Journal of medicinal chemistry 59 (9), 4152-4170, 2016 | 27 | 2016 |
Mechanism of RNA recognition by a Musashi RNA-binding protein J Wang, L Lan, X Wu, L Xu, Y Miao Current Research in Structural Biology 4, 10-20, 2022 | 19 | 2022 |
Identification of novel small molecule Beclin 1 mimetics activating autophagy J Yu, L Lan, SJ Lewin, SA Rogers, A Roy, X Wu, P Gao, J Karanicolas, ... Oncotarget 8 (31), 51355, 2017 | 19 | 2017 |
Identification and Validation of an Aspergillus nidulans Secondary Metabolite Derivative as an Inhibitor of the Musashi-RNA Interaction L Lan, J Liu, M Xing, AR Smith, J Wang, X Wu, C Appelman, K Li, A Roy, ... Cancers 12 (8), 2221, 2020 | 18 | 2020 |
Evidence for a transport-trap mode of Drosophila melanogaster gurken mRNA localization L Lan, S Lin, S Zhang, RS Cohen PLoS One 5 (11), e15448, 2010 | 17 | 2010 |
Rab11 Is Required for Epithelial Cell Viability, Terminal Differentiation, and Suppression of Tumor-Like Growth in the Drosophila Egg Chamber J Xu, L Lan, N Bogard, C Mattione, RS Cohen PloS one 6 (5), e20180, 2011 | 15 | 2011 |
Human oncoprotein Musashi-2 N-terminal RNA recognition motif backbone assignment and identification of RNA-binding pocket L Lan, M Xing, JT Douglas, P Gao, RP Hanzlik, L Xu Oncotarget 8 (63), 106587, 2017 | 14 | 2017 |
Small molecules targeting the RNA-binding protein HuR inhibit tumor growth in xenografts X Wu, R Ramesh, J Wang, Y Zheng, AM Armaly, L Wei, M Xing, S Roy, ... Journal of medicinal chemistry 66 (3), 2032-2053, 2023 | 9 | 2023 |
Crystal and solution structures of human oncoprotein Musashi‐2 N‐terminal RNA recognition motif 1 L Lan, M Xing, M Kashipathy, J Douglas, P Gao, K Battaile, R Hanzlik, ... Proteins: Structure, Function, and Bioinformatics 88 (4), 573-583, 2020 | 9 | 2020 |
Rationally designed inhibitors of the Musashi protein-RNA interaction by hotspot mimicry N Bai, Y Adeshina, I Bychkov, Y Xia, R Gowthaman, SA Miller, AK Gupta, ... bioRxiv, 2023 | 4 | 2023 |
Tumor suppressor miR-137 inhibits colorectal cancer progression by negatively regulating cancer stem cell marker, Musashi-1 AR Smith, R Marquez, B Tsao, L Lan, S Pathak, XF Sun, K Neufeld, L Xu Cancer Research 74 (19_Supplement), 1460-1460, 2014 | 3 | 2014 |