Development of the first small molecule histone deacetylase 6 (HDAC6) degraders K Yang, Y Song, H Xie, H Wu, YT Wu, ED Leisten, W Tang Bioorganic & medicinal chemistry letters 28 (14), 2493-2497, 2018 | 181 | 2018 |
Development of multifunctional histone deacetylase 6 degraders with potent antimyeloma activity H Wu, K Yang, Z Zhang, ED Leisten, Z Li, H Xie, J Liu, KA Smith, ... Journal of medicinal chemistry 62 (15), 7042-7057, 2019 | 156 | 2019 |
Development of selective histone deacetylase 6 (HDAC6) degraders recruiting von Hippel–Lindau (VHL) E3 ubiquitin ligase K Yang, H Wu, Z Zhang, ED Leisten, X Nie, B Liu, Z Wen, J Zhang, ... ACS Medicinal Chemistry Letters 11 (4), 575-581, 2020 | 98 | 2020 |
Two-stage strategy for development of proteolysis targeting chimeras and its application for estrogen receptor degraders BL Roberts, ZX Ma, A Gao, ED Leisten, D Yin, W Xu, W Tang ACS chemical biology 15 (6), 1487-1496, 2020 | 53 | 2020 |
Synthesis and biological evaluation of FICZ analogues as agonists of aryl hydrocarbon receptor H Wu, B Liu, K Yang, GN Winston-McPherson, ED Leisten, CM Vezina, ... Bioorganic & medicinal chemistry letters 30 (5), 126959, 2020 | 7 | 2020 |
Live cell microscopy of mitochondria-lysosome contact site formation and tethering dynamics TB Belton, ED Leisten, J Cisneros, YC Wong STAR protocols 3 (2), 101262, 2022 | 5 | 2022 |
Super-resolution microscopy: Insights into mitochondria–lysosome crosstalk in health and disease ED Leisten, AC Woods, YC Wong Journal of Cell Biology 222 (12), e202305032, 2023 | 4 | 2023 |
Insights into the mechanism of oligodendrocyte protection and remyelination enhancement by the integrated stress response Y Chen, S Quan, V Patil, RB Kunjamma, HM Tokars, ED Leisten, G Joy, ... Glia 71 (9), 2180-2195, 2023 | 4 | 2023 |
Two-stage strategy for development of proteolysis targeting chimeras and its application for estrogen receptor degraders. ACS Chem Biol. 2020 BL Roberts, ZX Ma, A Gao, ED Leisten, D Yin, W Xu, W Tang | 4 | |
Live Microscopy of Mitochondrial and Lysosomal Network Dynamics and Contact Site Misregulation in Neurodegenerative Diseases TB Belton, GC Shum, CG Molakal, J Cisneros, ED Leisten, YC Wong ANNALS OF NEUROLOGY 92, S118-S118, 2022 | | 2022 |
Lysosomal dynamic events revealed by superresolution live cell microscopy E Leisten, Y Wong Biophysical Journal 121 (3), 497a, 2022 | | 2022 |