A synthetic antibiotic class overcoming bacterial multidrug resistance MJ Mitcheltree, A Pisipati, EA Syroegin, KJ Silvestre, D Klepacki, ... Nature 599 (7885), 507-512, 2021 | 157 | 2021 |
Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance MS Svetlov, EA Syroegin, EV Aleksandrova, GC Atkinson, ST Gregory, ... Nature chemical biology 17 (4), 412-420, 2021 | 92 | 2021 |
Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol EA Syroegin, L Flemmich, D Klepacki, N Vazquez-Laslop, R Micura, ... Nature structural & molecular biology 29 (2), 152-161, 2022 | 50 | 2022 |
Insights into the ribosome function from the structures of non-arrested ribosome–nascent chain complexes EA Syroegin, EV Aleksandrova, YS Polikanov Nature chemistry 15 (1), 143-153, 2023 | 36 | 2023 |
Peptide inhibitors of bacterial protein synthesis with broad spectrum and SbmA-independent bactericidal activity against clinical pathogens M Mardirossian, R Sola, B Beckert, E Valencic, DWP Collis, J Borišek, ... Journal of medicinal chemistry 63 (17), 9590-9602, 2020 | 35 | 2020 |
An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance KJY Wu, BIC Tresco, A Ramkissoon, EV Aleksandrova, EA Syroegin, ... Science 383 (6684), 721-726, 2024 | 22 | 2024 |
Structural basis for the inability of chloramphenicol to inhibit peptide bond formation in the presence of A-site glycine EA Syroegin, EV Aleksandrova, YS Polikanov Nucleic acids research 50 (13), 7669-7679, 2022 | 22 | 2022 |
Structure of dirithromycin bound to the bacterial ribosome suggests new ways for rational improvement of macrolides NF Khabibullina, AG Tereshchenkov, ES Komarova, EA Syroegin, ... Antimicrobial Agents and Chemotherapy 63 (6), 10.1128/aac. 02266-18, 2019 | 14 | 2019 |
Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A CW Chen, N Leimer, EA Syroegin, C Dunand, ZP Bulman, K Lewis, ... Nature Communications 14 (1), 4196, 2023 | 10 | 2023 |
Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it EV Aleksandrova, KJY Wu, BIC Tresco, EA Syroegin, EE Killeavy, ... Nature Chemical Biology, 1-10, 2024 | 9 | 2024 |
Practical Synthesis of N-Formylmethionylated Peptidyl-tRNA Mimics J Thaler, EA Syroegin, K Breuker, YS Polikanov, R Micura ACS Chemical Biology 18 (10), 2233-2239, 2023 | 2 | 2023 |
Toxic small alarmone synthetase FaRel2 inhibits translation by pyrophosphorylating tRNAGly and tRNAThr T Kurata, M Takegawa, T Ohira, EA Syroegin, GC Atkinson, ... Science Advances 10 (46), eadr9624, 2024 | | 2024 |
Rationally Designed Pooled CRISPRi-Seq Uncovers an Inhibitor of Bacterial Peptidyl-tRNA Hydrolase ASMZ Rahman, EA Syroegin, J Novomisky Nechcoff, A Devarajan, ... bioRxiv, 2024.05. 02.592284, 2024 | | 2024 |