| Glutamic acid–valine–citrulline linkers ensure stability and efficacy of antibody–drug conjugates in mice Y Anami, CM Yamazaki, W Xiong, X Gui, N Zhang, Z An, K Tsuchikama Nature communications 9 (1), 2512, 2018 | 167 | 2018 |
| Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance CM Yamazaki, A Yamaguchi, Y Anami, W Xiong, Y Otani, J Lee, NT Ueno, ... Nature communications 12 (1), 3528, 2021 | 155 | 2021 |
| Enzymatic conjugation using branched linkers for constructing homogeneous antibody–drug conjugates with high potency Y Anami, W Xiong, X Gui, M Deng, CC Zhang, N Zhang, Z An, ... Organic & biomolecular chemistry 15 (26), 5635-5642, 2017 | 88 | 2017 |
| Disrupting LILRB4/APOE interaction by an efficacious humanized antibody reverses T-cell suppression and blocks AML development X Gui, M Deng, H Song, Y Chen, J Xie, Z Li, L He, F Huang, Y Xu, ... Cancer immunology research 7 (8), 1244-1257, 2019 | 66 | 2019 |
| Exploring the next generation of antibody–drug conjugates K Tsuchikama, Y Anami, SYY Ha, CM Yamazaki Nature Reviews Clinical Oncology 21 (3), 203-223, 2024 | 64 | 2024 |
| A mixed population of antagonist and agonist binding conformers in a single crystal explains partial agonism against vitamin D receptor: active vitamin D analogues with 22 R … Y Anami, T Itoh, D Egawa, N Yoshimoto, K Yamamoto Journal of medicinal chemistry 57 (10), 4351-4367, 2014 | 42 | 2014 |
| LILRB4-targeting antibody–drug conjugates for the treatment of acute myeloid leukemia Y Anami, M Deng, X Gui, A Yamaguchi, CM Yamazaki, N Zhang, ... Molecular cancer therapeutics 19 (11), 2330-2339, 2020 | 33 | 2020 |
| Apo-and antagonist-binding structures of vitamin D receptor ligand-binding domain revealed by hybrid approach combining small-angle X-ray scattering and molecular dynamics Y Anami, N Shimizu, T Ekimoto, D Egawa, T Itoh, M Ikeguchi, ... Journal of Medicinal Chemistry 59 (17), 7888-7900, 2016 | 33 | 2016 |
| Homogeneity of antibody-drug conjugates critically impacts the therapeutic efficacy in brain tumors Y Anami, Y Otani, W Xiong, SYY Ha, A Yamaguchi, KA Rivera-Caraballo, ... Cell reports 39 (8), 2022 | 28 | 2022 |
| An enzymatically cleavable tripeptide linker for maximizing the therapeutic index of antibody–drug conjugates SYY Ha, Y Anami, CM Yamazaki, W Xiong, CM Haase, SD Olson, J Lee, ... Molecular cancer therapeutics 21 (9), 1449-1461, 2022 | 25 | 2022 |
| Helix12-stabilization antagonist of vitamin D receptor A Kato, T Itoh, Y Anami, D Egawa, K Yamamoto Bioconjugate chemistry 27 (7), 1750-1761, 2016 | 25 | 2016 |
| Transglutaminase-mediated conjugations Y Anami, K Tsuchikama Antibody-Drug Conjugates: Methods and Protocols, 71-82, 2020 | 24 | 2020 |
| Identification of the histidine residue in vitamin D receptor that covalently binds to electrophilic ligands M Yoshizawa, T Itoh, T Hori, A Kato, Y Anami, N Yoshimoto, K Yamamoto Journal of Medicinal Chemistry 61 (14), 6339-6349, 2018 | 24 | 2018 |
| Total synthesis of the monomeric unit of lomaiviticin A KC Nicolaou, Q Chen, R Li, Y Anami, K Tsuchikama Journal of the American Chemical Society 142 (47), 20201-20207, 2020 | 21 | 2020 |
| Fine tuning of agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity Y Anami, Y Sakamaki, T Itoh, Y Inaba, M Nakabayashi, T Ikura, N Ito, ... Bioorganic & Medicinal Chemistry 23 (22), 7274-7281, 2015 | 17 | 2015 |
| Disrupting LILRB4/APOE interaction by an efficacious humanized antibody reverses T-cell suppression and blocks AML development. Cancer Immunol Res.(2019) 7: 1244–57. doi: 10 … X Gui, M Deng, H Song, Y Chen, J Xie, Z Li, L He, F Huang, Y Xu, ... DOI: https://doi. org/10.1158/2326-6066. CIR-19-0036, 1244-1257, 0 | 16 | |
| Enhanced anti-angiogenetic effect of transferrin receptor-mediated delivery of VEGF-trap in a glioblastoma mouse model P Zhao, Y Anami, P Gao, X Fan, L Li, K Tsuchikama, N Zhang, Z An MAbs 14 (1), 2057269, 2022 | 15 | 2022 |
| Development of vitamin D analogs modulating the pocket structure of vitamin D receptor K Yamamoto, Y Anami, T Itoh Current Topics in Medicinal Chemistry 14 (21), 2378-2387, 2014 | 14 | 2014 |
| Chemical generation of small molecule-based bispecific antibody-drug conjugates for broadening the target scope A Yamaguchi, Y Anami, SYY Ha, TJ Roeder, W Xiong, J Lee, NT Ueno, ... Bioorganic & Medicinal Chemistry 32, 116013, 2021 | 13 | 2021 |
| Truncated Autoinducing Peptide Conjugates Selectively Recognize and Kill Staphylococcus aureus K Tsuchikama, Y Shimamoto, Y Anami ACS Infectious Diseases 3 (6), 406-410, 2017 | 13 | 2017 |
