The cyclic peptide ecumicin targeting ClpC1 is active against Mycobacterium tuberculosis in vivo W Gao, JY Kim, JR Anderson, T Akopian, S Hong, YY Jin, O Kandror, ... Antimicrobial agents and chemotherapy 59 (2), 880-889, 2015 | 189 | 2015 |
Rufomycin targets ClpC1 proteolysis in Mycobacterium tuberculosis and M. abscessus MP Choules, NM Wolf, H Lee, JR Anderson, EM Grzelak, Y Wang, R Ma, ... Antimicrobial agents and chemotherapy 63 (3), 10.1128/aac. 02204-18, 2019 | 96 | 2019 |
Strategies in anti-Mycobacterium tuberculosis drug discovery based on phenotypic screening EM Grzelak, MP Choules, W Gao, G Cai, B Wan, Y Wang, JB McAlpine, ... The Journal of antibiotics 72 (10), 719-728, 2019 | 70 | 2019 |
Discovery and characterization of the tuberculosis drug lead ecumicin W Gao, JY Kim, SN Chen, SH Cho, J Choi, BU Jaki, YY Jin, DC Lankin, ... Organic letters 16 (23), 6044-6047, 2014 | 66 | 2014 |
Bioautography with TLC-MS/NMR for rapid discovery of anti-tuberculosis lead compounds from natural sources EM Grzelak, C Hwang, G Cai, JW Nam, MP Choules, W Gao, DC Lankin, ... ACS infectious diseases 2 (4), 294-301, 2016 | 56 | 2016 |
High-resolution structure of ClpC1-rufomycin and ligand binding studies provide a framework to design and optimize anti-tuberculosis leads NM Wolf, H Lee, MP Choules, GF Pauli, R Phansalkar, JR Anderson, ... ACS infectious diseases 5 (6), 829-840, 2019 | 53 | 2019 |
Quality Control of Therapeutic Peptides by 1H NMR HiFSA Sequencing MP Choules, J Bisson, W Gao, DC Lankin, JB McAlpine, M Niemitz, ... The Journal of organic chemistry 84 (6), 3055-3073, 2019 | 26 | 2019 |
A 13-week low glycemic load diet and lifestyle modification program combining low glycemic load protein shakes and targeted nutraceuticals improved weight loss and cardio … CJ Dahlberg, JJ Ou, JG Babish, JJ Lamb, S Eliason, H Brabazon, W Gao, ... Canadian Journal of Physiology and Pharmacology 95 (12), 1414-1425, 2017 | 21 | 2017 |
Synergistic in vitro antioxidant activity and observational clinical trial of F105, a phytochemical formulation including Citrus bergamia, in subjects with moderate … TML Babish JG, Dahlberg CJ, Ou JJ, Keller WJ, Gao W, Kaadige MR, Brabazon H ... Can J Physiol Pharmacol. 94 (12), 1257-1266, 2016 | 20 | 2016 |
A low-glycemic, Mediterranean diet and lifestyle modification program with targeted nutraceuticals reduces body weight, improves cardiometabolic variables and longevity … ML Tripp, CJ Dahlberg, S Eliason, JJ Lamb, JJ Ou, W Gao, J Bhandari, ... Journal of medicinal food 22 (5), 479-489, 2019 | 17 | 2019 |
Structural Sequencing of Oligopeptides Aided by 1H Iterative Full-Spin Analysis W Gao, JB McAlpine, MP Choules, JG Napolitano, DC Lankin, C Simmler, ... Journal of natural products 80 (10), 2630-2643, 2017 | 12 | 2017 |
Computer-assisted 1H NMR analysis of the anti-tuberculosis drug lead ecumicin W Gao, JG Napolitano, DC Lankin, JY Kim, YY Jin, H Lee, JW Suh, ... Magnetic resonance in chemistry: MRC 55 (3), 239, 2017 | 11 | 2017 |
Cyclic peptide from Nonomuraea sp., process for the production thereof, and pharmaceutical composition for the prevention or treatment of mycobacteria related disease … JW Kim, SW Lee, SJ Park, JW Suh, IA Lee, TM Yoon, JK Choi, JE Lee, ... US Patent 9,090,667, 2015 | 8 | 2015 |
A rufomycin analogue is an anti-tuberculosis drug lead targeting CLPC1 with no cross resistance to ecumicin M Choules, Y Yu, SH Cho, J Anderson, W Gao, L Klein, DC Lankin, ... Planta Medica 81 (11), CL2, 2015 | 7 | 2015 |
Compositions and methods for acutley raising nitric oxide levels ML Tripp, CJ Dahlberg, JG Babish, M Kaadige, W Gao US Patent 11,241,406, 2022 | 4 | 2022 |
Phytocomplexes exhibiting multiple, synergistic antioxidant activities useful in foods, dietary supplements, cosmetics and pharmaceutical preparations ML Tripp, CJ Dahlberg, JG Babish, W Gao, M Kaadige, S Krig, X Kou, ... US Patent 10,434,131, 2019 | 4 | 2019 |
Methods and compositions to enhance metabolic detoxification systems ML Tripp, CJ Dahlberg, JG Babish, J Lamb, JJ Ou, VR Konda, S Elison, ... US Patent App. 16/761,489, 2021 | 3 | 2021 |
New insights on the structure of the anti-TB peptide H14: crystal structure, 1H NMR full spin analysis, and biosynthetic pathway W Gao, JG Napolitano, JY Kim, IA Lee, JE Lee, J Choi, ... Planta Medica 78 (11), PJ134, 2012 | 2 | 2012 |
Methods and compositions to improve weight loss and cardiometabolic health beyond diet and excercise ML Tripp, CJ Dahlberg, JG Babish, J Lamb, JJ Ou, S Elison, W Gao, ... US Patent 11,122,832, 2021 | 1 | 2021 |
High-resolution structure of Clpc1-Ntd-Rufomycin complex provides three-dimensional framework for optimization of cyclopeptide anti-Tb drug leads N Wolf, H Lee, M Choules, L Klein, V Petukhova, M Tufano, R Phansalkar, ... PROTEIN SCIENCE 27, 119-120, 2018 | 1 | 2018 |