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Samantha Gildenhuys
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Expanding our understanding of the role polyprotein conformation plays in the coronavirus life cycle
S Gildenhuys
Biochemical Journal 477 (8), 1479-1482, 2020
332020
Benzofuran-selenadiazole hybrids as novel α-glucosidase and cyclooxygenase-2 inhibitors with antioxidant and cytotoxic properties
TO Olomola, MJ Mphahlele, S Gildenhuys
Bioorganic chemistry 100, 103945, 2020
282020
Synthesis, α-glucosidase inhibition and antioxidant activity of the 7-carbo–substituted 5-bromo-3-methylindazoles
MJ Mphahlele, NM Magwaza, S Gildenhuys, IB Setshedi
Bioorganic chemistry 97, 103702, 2020
272020
Arginine 15 stabilizes an SNAr reaction transition state and the binding of anionic ligands at the active site of human glutathione transferase A1-1
S Gildenhuys, M Dobreva, N Kinsley, Y Sayed, J Burke, S Pelly, ...
Biophysical chemistry 146 (2-3), 118-125, 2010
242010
Synthesis, In Vitro Evaluation and Molecular Docking of the 5-Acetyl-2-aryl-6-hydroxybenzo[b]furans against Multiple Targets Linked to Type 2 Diabetes
MJ Mphahlele, YS Choong, MM Maluleka, S Gildenhuys
Biomolecules 10 (3), 418, 2020
232020
Stability of the domain interface contributes towards the catalytic function at the H-site of class alpha glutathione transferase A1-1
D Balchin, S Fanucchi, I Achilonu, RJ Adamson, J Burke, M Fernandes, ...
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1804 (12), 2228-2233, 2010
232010
Synthesis of furocoumarin–stilbene hybrids as potential multifunctional drugs against multiple biochemical targets associated with Alzheimer’s disease
EN Agbo, S Gildenhuys, YS Choong, MJ Mphahlele, GK More
Bioorganic Chemistry 101, 103997, 2020
212020
Class Pi glutathione transferase unfolds via a dimeric and not monomeric intermediate: functional implications for an unstable monomer
S Gildenhuys, LA Wallace, JP Burke, D Balchin, Y Sayed, HW Dirr
Biochemistry 49 (24), 5074-5081, 2010
202010
Synthesis and evaluation of the 4-substituted 2-hydroxy-5-iodochalcones and their 7-substituted 6-iodoflavonol derivatives for inhibitory effect on cholinesterases and β-secretase
MJ Mphahlele, EN Agbo, S Gildenhuys
International Journal of Molecular Sciences 19 (12), 4112, 2018
172018
Analysis of conserved, computationally predicted epitope regions for VP5 and VP7 across three orbiviruses
BL Russell, N Parbhoo, S Gildenhuys
Bioinformatics and biology insights 12, 1177932218755348, 2018
162018
Exploring Biological Activity of 4-Oxo-4H-furo[2,3-h]chromene Derivatives as Potential Multi-Target-Directed Ligands Inhibiting Cholinesterases, β-Secretase …
MJ Mphahlele, EN Agbo, S Gildenhuys, IB Setshedi
Biomolecules 9 (11), 736, 2019
152019
The effects of temperature on streptavidin-biotin binding using affinity isothermal titration calorimetry
KL Mpye, S Gildenhuys, S Mosebi
AIMS Biophysics 7 (4), 236-247, 2020
122020
Functional screening of a soil metagenome for DNA endonucleases by acquired resistance to bacteriophage infection
S Mtimka, P Pillay, K Rashamuse, S Gildenhuys, TL Tsekoa
Molecular Biology Reports 47, 353-361, 2020
122020
Synthesis, Cytotoxicity and Molecular Docking Studies of the 9-Substituted 5-Styryltetrazolo[1,5-c]quinazoline Derivatives
MJ Mphahlele, S Gildenhuys, N Parbhoo
Molecules 22 (11), 1719, 2017
112017
In Vitro Evaluation and Docking Studies of 5-oxo-5H-furo[3,2-g]chromene-6-carbaldehyde Derivatives as Potential Anti-Alzheimer’s Agents
MJ Mphahlele, S Gildenhuys, EN Agbo
International Journal of Molecular Sciences 20 (21), 5451, 2019
102019
The role of a topologically conserved isoleucine in glutathione transferase structure, stability and function
I Achilonu, S Gildenhuys, L Fisher, J Burke, S Fanucchi, BT Sewell, ...
Acta Crystallographica Section F: Structural Biology and Crystallization …, 2010
102010
Effect of macromolecular crowding on the stability of monomeric glutaredoxin 2 and dimeric glutathione transferase A1-1
DC Kuhnert, S Gildenhuys, HW Dirr
South African Journal of Science 104 (1), 76-80, 2008
102008
Sequence analysis and structural implications of rotavirus capsid proteins
N Parbhoo, JB Dewar, S Gildenhuys
Acta Virol 60 (3), 260-270, 2016
82016
In vitro enzymatic and kinetic studies, and in silico drug-receptor interactions, and drug-like profiling of the 5-styrylbenzamide derivatives as potential cholinesterase and β …
MJ Mphahlele, EN Agbo, GK More, S Gildenhuys
Antioxidants 10 (5), 647, 2021
62021
Solubilisation and purification of recombinant bluetongue virus VP7 expressed in a bacterial system
BL Russell, S Gildenhuys
Protein Expression and Purification 147, 85-93, 2018
62018
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