| Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma G Bollag, P Hirth, J Tsai, J Zhang, PN Ibrahim, H Cho, W Spevak, C Zhang, ... Nature 467 (7315), 596-599, 2010 | 2071 | 2010 |
| The flavivirus precursor membrane-envelope protein complex: structure and maturation L Li, SM Lok, IM Yu, Y Zhang, RJ Kuhn, J Chen, MG Rossmann Science 319 (5871), 1830-1834, 2008 | 697 | 2008 |
| Structures of immature flavivirus particles Y Zhang, J Corver, PR Chipman, W Zhang, SV Pletnev, D Sedlak, ... The EMBO journal, 2003 | 668 | 2003 |
| Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model E Spangenberg, PL Severson, LA Hohsfield, J Crapser, J Zhang, ... Nature communications 10 (1), 3758, 2019 | 658 | 2019 |
| Visualization of membrane protein domains by cryo-electron microscopy of dengue virus W Zhang, PR Chipman, J Corver, PR Johnson, Y Zhang, ... Nature Structural & Molecular Biology 10 (11), 907-912, 2003 | 603 | 2003 |
| Conformational changes of the flavivirus E glycoprotein Y Zhang, W Zhang, S Ogata, D Clements, JH Strauss, TS Baker, RJ Kuhn, ... Structure 12 (9), 1607-1618, 2004 | 577 | 2004 |
| Structure-guided blockade of CSF1R kinase in tenosynovial giant-cell tumor WD Tap, ZA Wainberg, SP Anthony, PN Ibrahim, C Zhang, JH Healey, ... New England Journal of Medicine 373 (5), 428-437, 2015 | 566 | 2015 |
| Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN E Pokidysheva, Y Zhang, AJ Battisti, CM Bator-Kelly, PR Chipman, C Xiao, ... Cell 124 (3), 485-493, 2006 | 404 | 2006 |
| RAF inhibitors that evade paradoxical MAPK pathway activation C Zhang, W Spevak, Y Zhang, EA Burton, Y Ma, G Habets, J Zhang, J Lin, ... Nature 526 (7574), 583-586, 2015 | 386 | 2015 |
| Structure of immature West Nile virus Y Zhang, B Kaufmann, PR Chipman, RJ Kuhn, MG Rossmann Journal of virology 81 (11), 6141-6145, 2007 | 180 | 2007 |
| Characterizing and overriding the structural mechanism of the quizartinib-resistant FLT3 “gatekeeper” F691L mutation with PLX3397 CC Smith, C Zhang, KC Lin, EA Lasater, Y Zhang, E Massi, LE Damon, ... Cancer discovery 5 (6), 668-679, 2015 | 178 | 2015 |
| RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling Z Yao, Y Gao, W Su, R Yaeger, J Tao, N Na, Y Zhang, C Zhang, A Rymar, ... Nature medicine 25 (2), 284-291, 2019 | 164 | 2019 |
| BRD4 profiling identifies critical chronic lymphocytic leukemia oncogenic circuits and reveals sensitivity to PLX51107, a novel structurally distinct BET inhibitor HG Ozer, D El-Gamal, B Powell, ZA Hing, JS Blachly, B Harrington, ... Cancer discovery 8 (4), 458-477, 2018 | 123 | 2018 |
| Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor C Zhang, PN Ibrahim, J Zhang, EA Burton, G Habets, Y Zhang, B Powell, ... Proceedings of the National Academy of Sciences 110 (14), 5689-5694, 2013 | 111 | 2013 |
| Structural and virological studies of the stages of virus replication that are affected by antirhinovirus compounds Y Zhang, AA Simpson, RM Ledford, CM Bator, S Chakravarty, ... Journal of virology 78 (20), 11061-11069, 2004 | 70 | 2004 |
| Structural analysis of viral nucleocapsids by subtraction of partial projections Y Zhang, VA Kostyuchenko, MG Rossmann Journal of structural biology 157 (2), 356-364, 2007 | 57 | 2007 |
| Interaction of decay-accelerating factor with echovirus 7 P Plevka, S Hafenstein, KG Harris, JO Cifuente, Y Zhang, VD Bowman, ... Journal of virology 84 (24), 12665-12674, 2010 | 54 | 2010 |
| Structure and function of a chlorella virus-encoded glycosyltransferase Y Zhang, Y Xiang, JL Van Etten, MG Rossmann Structure 15 (9), 1031-1039, 2007 | 30 | 2007 |
| Association of combination of conformation-specific KIT inhibitors with clinical benefit in patients with refractory gastrointestinal stromal tumors: a phase 1b/2a … AJ Wagner, PL Severson, AF Shields, A Patnaik, R Chugh, G Tinoco, ... JAMA oncology 7 (9), 1343-1350, 2021 | 28 | 2021 |
| Crystal structure of a virus-encoded putative glycosyltransferase Y Xiang, U Baxa, Y Zhang, AC Steven, GL Lewis, JL Van Etten, ... Journal of virology 84 (23), 12265-12273, 2010 | 20 | 2010 |
