| Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse model with diabetes S Takeda, N Sato, K Uchio-Yamada, K Sawada, T Kunieda, D Takeuchi, ... Proceedings of the National Academy of Sciences 107 (15), 7036-7041, 2010 | 604 | 2010 |
| Tau PTM profiles identify patient heterogeneity and stages of Alzheimer’s disease H Wesseling, W Mair, M Kumar, CN Schlaffner, S Tang, P Beerepoot, ... Cell 183 (6), 1699-1713. e13, 2020 | 504 | 2020 |
| Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain S Takeda, S Wegmann, H Cho, SL DeVos, C Commins, AD Roe, ... Nature communications 6 (1), 8490, 2015 | 380 | 2015 |
| Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide T Hashimoto, A Serrano-Pozo, Y Hori, KW Adams, S Takeda, AO Banerji, ... Journal of Neuroscience 32 (43), 15181-15192, 2012 | 358 | 2012 |
| Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy S Takeda, N Sato, R Morishita Frontiers in aging neuroscience 6, 171, 2014 | 269 | 2014 |
| Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain E Hudry, J Dashkoff, AD Roe, S Takeda, RM Koffie, T Hashimoto, ... Science translational medicine 5 (212), 212ra161-212ra161, 2013 | 206 | 2013 |
| Angiotensin receptor blocker prevented β-amyloid-induced cognitive impairment associated with recovery of neurovascular coupling S Takeda, N Sato, D Takeuchi, H Kurinami, M Shinohara, K Niisato, ... Hypertension 54 (6), 1345-1352, 2009 | 191 | 2009 |
| CRISPR/Cas9 mediated disruption of the Swedish APP allele as a therapeutic approach for early-onset Alzheimer’s disease B György, C Lööv, MP Zaborowski, S Takeda, BP Kleinstiver, C Commins, ... Molecular Therapy-Nucleic Acids 11, 429-440, 2018 | 186 | 2018 |
| Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function S Takeda, N Sato, H Rakugi, R Morishita Molecular BioSystems 7 (6), 1822-1827, 2011 | 181 | 2011 |
| Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain M Arbel-Ornath, E Hudry, JR Boivin, T Hashimoto, S Takeda, ... Molecular neurodegeneration 12, 1-14, 2017 | 174 | 2017 |
| Oxidative stress and lipid peroxidation are upstream of amyloid pathology M Arimon, S Takeda, KL Post, S Svirsky, BT Hyman, O Berezovska Neurobiology of disease 84, 109-119, 2015 | 156 | 2015 |
| Increased blood–brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model S Takeda, N Sato, K Ikimura, H Nishino, H Rakugi, R Morishita Neurobiology of aging 34 (8), 2064-2070, 2013 | 144 | 2013 |
| Reduction of brain β-amyloid (Aβ) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, through increase in degradation of amyloid precursor protein C-terminal … M Shinohara, N Sato, H Kurinami, D Takeuchi, S Takeda, M Shimamura, ... Journal of biological chemistry 285 (29), 22091-22102, 2010 | 130 | 2010 |
| Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity S Wegmann, EA Maury, MJ Kirk, L Saqran, A Roe, SL DeVos, S Nicholls, ... The EMBO journal 34 (24), 3028-3041, 2015 | 126 | 2015 |
| Novel method for rapid assessment of cognitive impairment using high-performance eye-tracking technology A Oyama, S Takeda, Y Ito, T Nakajima, Y Takami, Y Takeya, K Yamamoto, ... Scientific reports 9 (1), 12932, 2019 | 125 | 2019 |
| Seed‐competent high‐molecular‐weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients S Takeda, C Commins, SL DeVos, CK Nobuhara, S Wegmann, AD Roe, ... Annals of neurology 80 (3), 355-367, 2016 | 120 | 2016 |
| Tau antibody targeting pathological species blocks neuronal uptake and interneuron propagation of tau in vitro CK Nobuhara, SL DeVos, C Commins, S Wegmann, BD Moore, AD Roe, ... The American journal of pathology 187 (6), 1399-1412, 2017 | 110 | 2017 |
| Secretion and uptake of α-synuclein via extracellular vesicles in cultured cells G Gustafsson, C Lööv, E Persson, DF Lázaro, S Takeda, J Bergström, ... Cellular and molecular neurobiology 38, 1539-1550, 2018 | 92 | 2018 |
| Recycling of abrasives from wasted slurry by superconducting magnetic separation S Nishijima, Y Izumi, S Takeda, H Suemoto, A Nakahira, S Horie IEEE Transactions on applied superconductivity 13 (2), 1596-1599, 2003 | 84 | 2003 |
| A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer disease Y Hori, S Takeda, H Cho, S Wegmann, TM Shoup, K Takahashi, D Irimia, ... Journal of Biological Chemistry 290 (4), 1966-1978, 2015 | 79 | 2015 |
