| International Union of Pharmacology. XII. Classification of opioid receptors BN Dhawan, F Cesselin, R Raghubir, T Reisine, PB Bradley, ... Pharmacological reviews 48 (4), 567-592, 1996 | 1092 | 1996 |
| Naltrindole, a highly selective and potent non-peptide δ opioid receptor antagonist PS Portoghese, M Sultana, AE Takemori European journal of pharmacology 146 (1), 185-186, 1988 | 726 | 1988 |
| Binaltorphimine and nor-binaltorphimine, potent and selective k-opioid receptor antagonists PS Portoghese, AW Lipkowski, AE Takemori Life sciences 40 (13), 1287-1292, 1987 | 685 | 1987 |
| Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice. EE Abdelhamid, M Sultana, PS Portoghese, AE Takemori Journal of Pharmacology and Experimental Therapeutics 258 (1), 299-303, 1991 | 588 | 1991 |
| Antidepressant-like effects of κ-opioid receptor antagonists in the forced swim test in rats SD Mague, AM Pliakas, MS Todtenkopf, HC Tomasiewicz, Y Zhang, ... Journal of Pharmacology and Experimental Therapeutics 305 (1), 323-330, 2003 | 584 | 2003 |
| Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays. AE Takemori, BY Ho, JS Naeseth, PS Portoghese Journal of Pharmacology and Experimental Therapeutics 246 (1), 255-258, 1988 | 525 | 1988 |
| Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. M Sofuoglu, PS Portoghese, AE Takemori Journal of Pharmacology and Experimental Therapeutics 257 (2), 676-680, 1991 | 443 | 1991 |
| A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities PS Portoghese, DL Larson, LM Sayre, DS Fries, AE Takemori Journal of medicinal chemistry 23 (3), 233-234, 1980 | 414 | 1980 |
| Pharmacological characterization in vivo of the novel opiate, beta-funaltrexamine. SJ Ward, PS Portoghese, AE Takemori Journal of Pharmacology and Experimental Therapeutics 220 (3), 494-498, 1982 | 410 | 1982 |
| A new concept on the mode of interaction of narcotic analgesics with receptors PS Portoghese Journal of medicinal chemistry 8 (5), 609-616, 1965 | 405 | 1965 |
| A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers M Waldhoer, J Fong, RM Jones, MM Lunzer, SK Sharma, E Kostenis, ... Proceedings of the National Academy of Sciences 102 (25), 9050-9055, 2005 | 401 | 2005 |
| Design of peptidomimetic. delta. opioid receptor antagonists using the message-address concept PS Portoghese, M Sultana, AE Takemori Journal of medicinal chemistry 33 (6), 1714-1720, 1990 | 384 | 1990 |
| Differential antagonism of opioid delta antinociception by [D-Ala2, Leu5, Cys6] enkephalin and naltrindole 5'-isothiocyanate: evidence for delta receptor subtypes. Q Jiang, AE Takemori, M Sultana, PS Portoghese, WD Bowen, ... Journal of Pharmacology and Experimental Therapeutics 257 (3), 1069-1075, 1991 | 370 | 1991 |
| Application of the message-address concept in the design of highly potent and selective non-peptide. delta. opioid receptor antagonists PS Portoghese, M Sultana, H Nagase, AE Takemori Journal of medicinal chemistry 31 (2), 281-282, 1988 | 353 | 1988 |
| Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series DJ Daniels, NR Lenard, CL Etienne, PY Law, SC Roerig, PS Portoghese Proceedings of the National Academy of Sciences 102 (52), 19208-19213, 2005 | 335 | 2005 |
| Bivalent ligands and the message-address concept in the design of selective opioid receptor antagonists PS Portoghese Trends in pharmacological sciences 10 (6), 230-235, 1989 | 330 | 1989 |
| Effects of κ-opioid receptor ligands on intracranial self-stimulation in rats MS Todtenkopf, JF Marcus, PS Portoghese, WA Carlezon Psychopharmacology 172, 463-470, 2004 | 327 | 2004 |
| The irreversible narcotic antagonistic and reversible agonistic properties of the fumaramate methyl ester derivative of naltrexone AE Takemori, DL Larson, PS Portoghese European journal of pharmacology 70 (4), 445-451, 1981 | 322 | 1981 |
| Morphine promotes the growth of HIV-1 in human peripheral blood mononuclear cell cocultures PK Peterson, BM Sharp, G Gekker, PS Portoghese, K Sannerud, ... Aids 4 (9), 869-874, 1990 | 282 | 1990 |
| Safety assessment of allylalkoxybenzene derivatives used as flavouring substances—methyl eugenol and estragole RL Smith, TB Adams, J Doull, VJ Feron, JI Goodman, LJ Marnett, ... Food and chemical Toxicology 40 (7), 851-870, 2002 | 264 | 2002 |
