RNA binding antagonizes neurotoxic phase transitions of TDP-43 JR Mann, AM Gleixner, JC Mauna, E Gomes, MR DeChellis-Marks, ... Neuron 102 (2), 321-338. e8, 2019 | 455 | 2019 |
Viability assays for cells in culture JM Posimo, AS Unnithan, AM Gleixner, HJ Choi, Y Jiang, SH Pulugulla, ... Journal of visualized experiments: JoVE, 2014 | 72 | 2014 |
NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility AM Gleixner, BM Verdone, CG Otte, EN Anderson, N Ramesh, ... Nature communications 13 (1), 3380, 2022 | 41 | 2022 |
Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology EN Anderson, AA Morera, S Kour, JD Cherry, N Ramesh, A Gleixner, ... Elife 10, e67587, 2021 | 41 | 2021 |
N-Acetyl-l-cysteine protects astrocytes against proteotoxicity without recourse to glutathione AM Gleixner, DF Hutchison, S Sannino, TN Bhatia, LC Leak, PT Flaherty, ... Molecular pharmacology 92 (5), 564-575, 2017 | 39 | 2017 |
Astrocytes do not forfeit their neuroprotective roles after surviving intense oxidative stress TN Bhatia, DB Pant, EA Eckhoff, RN Gongaware, T Do, DF Hutchison, ... Frontiers in molecular neuroscience 12, 87, 2019 | 38 | 2019 |
Neocortex and allocortex respond differentially to cellular stress in vitro and aging in vivo JM Posimo, AM Titler, HJH Choi, AS Unnithan, RK Leak PloS one 8 (3), e58596, 2013 | 37 | 2013 |
N-acetyl cysteine prevents synergistic, severe toxicity from two hits of oxidative stress AS Unnithan, Y Jiang, JL Rumble, SH Pulugulla, JM Posimo, AM Gleixner, ... Neuroscience letters 560, 71-76, 2014 | 35 | 2014 |
Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization I Casci, K Krishnamurthy, S Kour, V Tripathy, N Ramesh, EN Anderson, ... Nature Communications 10 (1), 5583, 2019 | 32 | 2019 |
Impact of aging on heat shock protein expression in the substantia nigra and striatum of the female rat AM Gleixner, SH Pulugulla, DB Pant, JM Posimo, TS Crum, RK Leak Cell and tissue research 357, 43-54, 2014 | 31 | 2014 |
Rescue from a two hit, high-throughput model of neurodegeneration with N-acetyl cysteine AS Unnithan, HJH Choi, AM Titler, JM Posimo, RK Leak Neurochemistry international 61 (3), 356-368, 2012 | 27 | 2012 |
N-Acetyl cysteine blunts proteotoxicity in a heat shock protein-dependent manner Y Jiang, JL Rumble, AM Gleixner, AS Unnithan, SH Pulugulla, JM Posimo, ... Neuroscience 255, 19-32, 2013 | 26 | 2013 |
Astrocyte plasticity revealed by adaptations to severe proteotoxic stress. AM Titler, JM Posimo, RK Leak Cell Tissue Research, 2013 | 26 | 2013 |
Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy B Khalil, D Chhangani, MC Wren, CL Smith, JH Lee, X Li, C Puttinger, ... Molecular neurodegeneration 17 (1), 80, 2022 | 24 | 2022 |
RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3 N Ramesh, EL Daley, AM Gleixner, JR Mann, S Kour, D Mawrie, ... Acta Neuropathologica Communications 8, 1-20, 2020 | 23 | 2020 |
Astrocytes surviving severe stress can still protect neighboring neurons from proteotoxic injury AM Gleixner, JM Posimo, DB Pant, MP Henderson, RK Leak Molecular neurobiology 53, 4939-4960, 2016 | 23 | 2016 |
Heat shock protein responses to aging and proteotoxicity in the olfactory bulb TS Crum, AM Gleixner, JM Posimo, DM Mason, MT Broeren, ... Journal of neurochemistry 133 (6), 780-794, 2015 | 22 | 2015 |
Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo CG Otte, TR Fortuna, JR Mann, AM Gleixner, N Ramesh, NJ Pyles, ... Neurobiology of disease 146, 105078, 2020 | 17 | 2020 |
Heat shock protein defenses in the neocortex and allocortex of the telencephalon JM Posimo, JN Weilnau, AM Gleixner, MT Broeren, NL Weiland, ... Neurobiology of aging 36 (5), 1924-1937, 2015 | 14 | 2015 |
astrocytes do not forfeit their neuroprotective roles after surviving intense oxidative stress. Front Mol Neurosci 12: 87 TN Bhatia, DB Pant, EA Eckhoff, RN Gongaware, T Do, DF Hutchison, ... | 6 | 2019 |