A human pluripotent stem cell-based platform to study SARS-CoV-2 tropism and model virus infection in human cells and organoids L Yang, Y Han, BE Nilsson-Payant, V Gupta, P Wang, X Duan, X Tang, ... Cell stem cell 27 (1), 125-136. e7, 2020 | 676 | 2020 |
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis W Van Rheenen, A Shatunov, AM Dekker, RL McLaughlin, FP Diekstra, ... Nature genetics 48 (9), 1043-1048, 2016 | 603 | 2016 |
Microglia innately develop within cerebral organoids PR Ormel, R Vieira de Sá, EJ Van Bodegraven, H Karst, O Harschnitz, ... Nature communications 9 (1), 4167, 2018 | 487 | 2018 |
The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2 L Bauer, BM Laksono, FMS de Vrij, SA Kushner, O Harschnitz, D van Riel Trends in neurosciences 45 (5), 358-368, 2022 | 150 | 2022 |
Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease SR Guttikonda, L Sikkema, J Tchieu, N Saurat, RM Walsh, O Harschnitz, ... Nature Neuroscience 24 (3), 343-354, 2021 | 147 | 2021 |
Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis FG *Lafaille, O *Harschnitz, YS *Lee, P *Zhang, ML Hasek, G Kerner, ... Nature Medicine 25 (12), 1873-1884, 2019 | 102 | 2019 |
Revising two-point discrimination assessment in normal aging and in patients with polyneuropathies SI van Nes, CG Faber, RMTP Hamers, O Harschnitz, M Bakkers, ... Journal of Neurology, Neurosurgery & Psychiatry 79 (7), 832-834, 2008 | 102 | 2008 |
TLR3 controls constitutive IFN-b antiviral immunity in human fibroblasts and cortical neurons D Gao, MJ Ciancanelli*, P Zhang*, O Harschnitz*, V Bondet, M Hasek, ... The Journal of Clinical Investigation, 2020 | 82 | 2020 |
Human iPSC-derived trigeminal neurons lack constitutive TLR3-dependent immunity that protects cortical neurons from HSV-1 infection B Zimmer, O Ewaleifoh, O Harschnitz, YS Lee, C Peneau, JL McAlpine, ... Proceedings of the National Academy of Sciences 115 (37), E8775-E8782, 2018 | 66 | 2018 |
Autoantibody pathogenicity in a multifocal motor neuropathy induced pluripotent stem cell–derived model O Harschnitz, LH van den Berg, LE Johansen, MD Jansen, S Kling, ... Annals of Neurology 80 (1), 71-88, 2016 | 62 | 2016 |
SARS-CoV-2 infection causes dopaminergic neuron senescence L Yang*, TW Kim*, Y Han*, MS Nair*, O Harschnitz*, J Zhu*, P Wang, ... Cell Stem Cell, 2021 | 56 | 2021 |
Whole blood transcriptome analysis in amyotrophic lateral sclerosis: A biomarker study W Van Rheenen, FP Diekstra, O Harschnitz, HJ Westeneng, KR van Eijk, ... PloS one 13 (6), e0198874, 2018 | 49 | 2018 |
Taking a risk: a therapeutic focus on ataxin-2 in amyotrophic lateral sclerosis? DMA van den Heuvel, O Harschnitz, LH van den Berg, RJ Pasterkamp Trends in Molecular Medicine 20 (1), 25-35, 2014 | 41 | 2014 |
Human stem cell models to study host–virus interactions in the central nervous system O Harschnitz, L Studer Nature Reviews Immunology 21 (7), 441-453, 2021 | 38 | 2021 |
A comparative study of SMN protein and mRNA in blood and fibroblasts in patients with spinal muscular atrophy and healthy controls RI Wadman, M Stam, MD Jansen, Y van der Weegen, CA Wijngaarde, ... PloS one 11 (11), e0167087, 2016 | 36 | 2016 |
Complement activity is associated with disease severity in multifocal motor neuropathy L Vlam, EA Cats, O Harschnitz, MD Jansen, S Piepers, JH Veldink, ... Neuroimmunology & Neuroinflammation 2 (4), e119, 2015 | 36 | 2015 |
MMN: from immunological cross-talk to conduction block O Harschnitz, BA Jongbloed, H Franssen, DCG Straver, WL van der Pol, ... Journal of Clinical Immunology 34, 112-119, 2014 | 35 | 2014 |
Facial onset sensory and motor neuronopathy: new cases, cognitive changes, and pathophysiology EMJ De Boer, AW Barritt, M Elamin, SJ Anderson, R Broad, A Nisbet, ... Neurology: Clinical Practice 11 (2), 147-157, 2021 | 22 | 2021 |
Neuron-intrinsic immunity to viruses in mice and humans SY Zhang, O Harschnitz, L Studer, JL Casanova Current opinion in immunology 72, 309-317, 2021 | 13 | 2021 |
Intracranial application of free fasciocutaneous flaps in a novel sandwich technique for skull base reconstruction RD Largo, DJ Schaefer, J Krueger, O Harschnitz, S Zimmerer, C Jaquiéry, ... International journal of oral and maxillofacial surgery 40 (9), 931-937, 2011 | 12 | 2011 |