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Iván Parra Izquierdo
Iván Parra Izquierdo
Senior Scientist at Boehringer Ingelheim
在 boehringer-ingelheim.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Phosphoproteomic quantitation and causal analysis reveal pathways in GPVI/ITAM-mediated platelet activation programs
Ö Babur, AR Melrose, JM Cunliffe, J Klimek, J Pang, ALI Sepp, ...
Blood, The Journal of the American Society of Hematology 136 (20), 2346-2358, 2020
712020
Toll-like receptors, inflammation, and calcific aortic valve disease
C Garcia-Rodriguez, I Parra-Izquierdo, I Castanos-Mollor, J López, ...
Frontiers in physiology 9, 201, 2018
702018
Lipopolysaccharide and interferon-γ team up to activate HIF-1α via STAT1 in normoxia and exhibit sex differences in human aortic valve interstitial cells
I Parra-Izquierdo, I Castaños-Mollor, J López, C Gómez, JA San Román, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1865 (9 …, 2019
552019
Calcification induced by type I interferon in human aortic valve interstitial cells is larger in males and blunted by a janus kinase inhibitor
I Parra-Izquierdo, I Castaños-Mollor, J López, C Gómez, JA San Román, ...
Arteriosclerosis, Thrombosis, and Vascular Biology 38 (9), 2148-2159, 2018
502018
Perspectives on platelet heterogeneity and host immune response in coronavirus disease 2019 (COVID-19)
I Parra-Izquierdo, JE Aslan
Seminars in thrombosis and hemostasis 46 (07), 826-830, 2020
182020
Janus kinase inhibitors ruxolitinib and baricitinib impair glycoprotein-VI mediated platelet function
I Parra-Izquierdo, AR Melrose, J Pang, HHS Lakshmanan, SE Reitsma, ...
Platelets 33 (3), 404-415, 2022
172022
The toll-like receptor 2 ligand Pam2CSK4 activates platelet nuclear factor-κB and Bruton’s tyrosine kinase signaling to promote platelet-endothelial cell interactions
I Parra-Izquierdo, HHS Lakshmanan, AR Melrose, J Pang, TJ Zheng, ...
Frontiers in immunology 12, 729951, 2021
152021
CRISPR-edited megakaryocytes for rapid screening of platelet gene functions
E Montenont, S Bhatlekar, S Jacob, Y Kosaka, BK Manne, O Lee, ...
Blood Advances 5 (9), 2362-2374, 2021
132021
Interferons are pro-inflammatory cytokines in sheared-stressed human aortic valve endothelial cells
I Parra-Izquierdo, T Sánchez-Bayuela, J López, C Gómez, ...
International journal of molecular sciences 22 (19), 10605, 2021
112021
Thrombin generation and activity in multiple sclerosis
KR Jordan, I Parra-Izquierdo, A Gruber, JJ Shatzel, P Pham, LS Sherman, ...
Metabolic brain disease 36, 407-420, 2021
102021
Platelet miR-223 delivery rescues vascular cells in Kawasaki disease
I Parra-Izquierdo, OJT McCarty, JE Aslan
Circulation research 127 (7), 874-876, 2020
102020
Rho GTPase regulation of reactive oxygen species generation and signalling in platelet function and disease
ATP Ngo, I Parra-Izquierdo, JE Aslan, OJT McCarty
Small GTPases 12 (5-6), 440-457, 2021
92021
Effect of antiplatelet agents and tyrosine kinase inhibitors on oxLDL-mediated procoagulant platelet activity
TJ Zheng, TCL Kohs, PA Mueller, J Pang, SE Reitsma, I Parra-Izquierdo, ...
Blood Advances 7 (8), 1366-1378, 2023
72023
Clinically used JAK inhibitor blunts dsRNA‐induced inflammation and calcification in aortic valve interstitial cells
I Parra‐Izquierdo, T Sánchez‐Bayuela, I Castaños‐Mollor, J López, ...
The FEBS Journal 288 (22), 6528-6542, 2021
72021
Platelets get gutted by PAG
I Parra-Izquierdo, R Bradley, JE Aslan
Platelets 31 (5), 618-620, 2020
72020
Platelets and tyrosine kinase inhibitors: clinical features, mechanisms of action, and effects on physiology
TJ Zheng, I Parra-Izquierdo, SE Reitsma, MC Heinrich, MK Larson, ...
American Journal of Physiology-Cell Physiology 323 (4), C1231-C1250, 2022
62022
Chronic edible dosing of Δ9-tetrahydrocannabinol (THC) in nonhuman primates reduces systemic platelet activity and function
SE Reitsma, HHS Lakshmanan, J Johnson, J Pang, I Parra-Izquierdo, ...
American Journal of Physiology-Cell Physiology 322 (3), C370-C381, 2022
62022
Activation of coagulation FXI promotes endothelial inflammation and amplifies platelet activation in a nonhuman primate model of hyperlipidemia
TCL Kohs, HH Vu, KR Jordan, I Parra-Izquierdo, MT Hinds, JJ Shatzel, ...
Research and Practice in Thrombosis and Haemostasis 8 (1), 102276, 2024
12024
PB0705 Pharmacological Inhibition of Coagulation Factor XI Reduces Thromboinflammation in a Nonhuman Primate Model of Early Atherosclerosis
T Kohs, I Parra-Izquierdo, H Vu, K Jordan, M Hinds, J Shatzel, P Kievit, ...
Research and Practice in Thrombosis and Haemostasis 7, 101308, 2023
2023
Metabolic rewiring is required for calcification and osteogenic differentiation in human aortic valve interstitial cells exposed to an inflammatory environment
T Sánchez-Bayuela, PR Miriam, I Parra Izquierdo, J López, C Gómez, ...
2023
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