Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors EE Brown, AJ DeWeerd, CJ Ildefonso, AS Lewin, JD Ash Redox biology 24, 101201, 2019 | 187 | 2019 |
Systemic treatment with a 5HT1a agonist induces anti-oxidant protection and preserves the retina from mitochondrial oxidative stress MR Biswal, CM Ahmed, CJ Ildefonso, P Han, H Li, H Jivanji, H Mao, ... Experimental eye research 140, 94-105, 2015 | 47 | 2015 |
Neuroinflammation in retinitis pigmentosa, diabetic retinopathy, and age-related macular degeneration: a minireview MT Massengill, CM Ahmed, AS Lewin, CJ Ildefonso Retinal Degenerative Diseases: Mechanisms and Experimental Therapy, 185-191, 2018 | 43 | 2018 |
The NLRP3 inflammasome and its role in age-related macular degeneration CJ Ildefonso, MR Biswal, CM Ahmed, AS Lewin Retinal Degenerative Diseases: Mechanisms and Experimental Therapy, 59-65, 2016 | 39 | 2016 |
Targeting the Nrf2 signaling pathway in the retina with a gene-delivered secretable and cell-penetrating peptide CJ Ildefonso, H Jaime, EE Brown, RL Iwata, CM Ahmed, MT Massengill, ... Investigative ophthalmology & visual science 57 (2), 372-386, 2016 | 35 | 2016 |
Gene Delivery of a Viral Anti-inflammatory Protein to Combat Ocular Inflammation CJ Ildefonso, J H, R MM, Q Li, SE Boye, WW Hauswirth, AR Lucas, ... Human Gene Therapy, 2014 | 30 | 2014 |
A cell penetrating peptide from SOCS-1 prevents ocular damage in experimental autoimmune uveitis CM Ahmed, MT Massengill, EE Brown, CJ Ildefonso, HM Johnson, ... Experimental eye research 177, 12-22, 2018 | 28 | 2018 |
Timing of antioxidant gene therapy: implications for treating dry AMD MR Biswal, P Han, P Zhu, Z Wang, H Li, CJ Ildefonso, AS Lewin Investigative Ophthalmology & Visual Science 58 (2), 1237-1245, 2017 | 27 | 2017 |
Absence of systemic immune response to adenovectors after intraocular administration to children with retinoblastoma CJ Ildefonso, L Kong, A Leen, SJ Chai, V Petrochelli, M Chintagumpala, ... Molecular Therapy 18 (10), 1885-1890, 2010 | 25 | 2010 |
Deriving immune modulating drugs from viruses—a new class of biologics JR Yaron, L Zhang, Q Guo, M Burgin, LN Schutz, E Awo, L Wise, ... Journal of Clinical Medicine 9 (4), 972, 2020 | 22 | 2020 |
Conditional induction of oxidative stress in RPE: a mouse model of progressive retinal degeneration MR Biswal, CJ Ildefonso, H Mao, SJ Seo, Z Wang, H Li, YZ Le, AS Lewin Retinal Degenerative Diseases: Mechanisms and Experimental Therapy, 31-37, 2016 | 22 | 2016 |
Systematic review and meta-analysis of the association between complement factor H I62V polymorphism and risk of polypoidal choroidal vasculopathy in Asian populations ZY Wang, K Zhao, J Zheng, B Rossmiller, C Ildefonso, M Biswal, P Zhao PLoS One 9 (2), e88324, 2014 | 21 | 2014 |
Repurposing an orally available drug for the treatment of geographic atrophy CM Ahmed, MR Biswal, H Li, P Han, CJ Ildefonso, AS Lewin Molecular vision 22, 294, 2016 | 20 | 2016 |
Gene therapy with the caspase activation and recruitment domain reduces the ocular inflammatory response CJ Ildefonso, H Jaime, MR Biswal, SE Boye, Q Li, WW Hauswirth, ... Molecular Therapy 23 (5), 875-884, 2015 | 20 | 2015 |
Altered subcellular signaling in murine peritoneal macrophages upon chronic morphine exposure AM Lugo-Chinchilla, D Báez, M Vélez, C Ildefonso, FL Renaud Journal of neuroimmunology 176 (1-2), 86-94, 2006 | 20 | 2006 |
Expression of a CARD slows the retinal degeneration of a geographic atrophy mouse model BM Young, K Jones, MT Massengill, E Walsh, H Li, AS Lewin, ... Molecular Therapy Methods & Clinical Development 14, 113-125, 2019 | 13 | 2019 |
Clinically relevant outcome measures for the I307N rhodopsin mouse: a model of inducible autosomal dominant retinitis pigmentosa MT Massengill, B Young, D Patel, F Jafri, E Sabogal, N Ash, H Li, ... Investigative Ophthalmology & Visual Science 59 (13), 5417-5430, 2018 | 13 | 2018 |
Sectoral activation of glia in an inducible mouse model of autosomal dominant retinitis pigmentosa MT Massengill, NF Ash, BM Young, CJ Ildefonso, AS Lewin Scientific reports 10 (1), 16967, 2020 | 11 | 2020 |
Delivery of Nrf2 as therapy for protection against reactive oxygen species CJ Ildefonso, AS Lewin, Q Li US Patent 11,053,291, 2021 | 8 | 2021 |
Corneal application of R9-SOCS1-KIR peptide alleviates endotoxin-induced uveitis CM Ahmed, AP Patel, CJ Ildefonso, HM Johnson, AS Lewin Translational Vision Science & Technology 10 (3), 25-25, 2021 | 7 | 2021 |