Matrix metalloproteinase MMP-12 promotes macrophage transmigration across intestinal epithelial tight junctions and increases severity of experimental colitis M Nighot, AS Ganapathy, K Saha, E Suchanec, EF Castillo, A Gregory, ... Journal of Crohn's and Colitis 15 (10), 1751-1765, 2021 | 66 | 2021 |
AP2M1 mediates autophagy-induced CLDN2 (claudin 2) degradation through endocytosis and interaction with LC3 and reduces intestinal epithelial tight junction permeability TMPN Ashwinkumar Subramenium Ganapathy, Kushal Saha, Eric Suchanec, Ayush ... Autophagy 17 (12), 2021 | 57* | 2021 |
Autophagy reduces the degradation and promotes membrane localization of occludin to enhance the intestinal epithelial tight junction barrier against paracellular macromolecule flux K Saha, A Subramenium Ganapathy, A Wang, N Michael Morris, ... Journal of Crohn's and Colitis 17 (3), 433-449, 2023 | 35 | 2023 |
Long-Term use of proton pump inhibitors disrupts intestinal tight junction barrier and exaggerates experimental colitis M Nighot, PL Liao, N Morris, D McCarthy, V Dharmaprakash, I Ullah Khan, ... Journal of Crohn's and Colitis 17 (4), 565-579, 2023 | 20 | 2023 |
Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways AS Ganapathy, K Saha, A Wang, P Arumugam, V Dharmaprakash, ... Cell reports 42 (7), 2023 | 13 | 2023 |
Alpha-tocopherylquinone-mediated activation of the Aryl Hydrocarbon Receptor regulates the production of inflammation-inducing cytokines and ameliorates intestinal inflammation K Saha, AS Ganapathy, A Wang, P Arumugam, NM Morris, L Harris, ... Mucosal immunology 16 (6), 826-842, 2023 | 2 | 2023 |
Autophagy Increases Occludin Levels to Enhance Intestinal Paracellular Tight Junction Barrier K Saha, AS Ganapathy, A Wang, NM Morris, E Suchanec, G Yochum, ... bioRxiv, 2022.04. 11.487876, 2022 | 1 | 2022 |
Tight junction regulation, intestinal permeability, and mucosal immunity in gastrointestinal health and disease K Saha, Y Zhou, JR Turner Current Opinion in Gastroenterology 41 (1), 46-53, 2025 | | 2025 |
Regional Heterogeneity in Intestinal Epithelial Barrier Permeability and Mesenteric Perfusion After Thoracic Spinal Cord Injury JB Radler, AR McBride, K Saha, P Nighot, GM Holmes Digestive Diseases and Sciences 69 (9), 3236-3248, 2024 | | 2024 |
107 AUTOPHAGY AMELIORATES ER STRESS-MEDIATED INTESTINAL TIGHT JUNCTION BARRIER DYSFUNCTION P Arumugam, AS Ganapathy, K Saha, P Nighot Gastroenterology 166 (5), S-29-S-30, 2024 | | 2024 |
Intestinal Epithelial Tight Junction Barrier Regulation by Novel Pathways P Arumugam, K Saha, P Nighot Inflammatory Bowel Diseases, 2024 | | 2024 |
Assessing novel mechanisms to understand the dynamics of the Intestinal milieu in Inflammatory Bowel Diseases. K Saha | | 2024 |
Intestinal epithelium-specific deletion of the Aryl hydrocarbon Receptor (AhR) reduces intestinal Tight Junction permeability thereby hindering homeostatic antigen sampling and … K Saha, AS Ganapathy, P Arumugam, A Wang, L Harris, G Yochum, ... JOURNAL OF CROHNS & COLITIS 18, I227-I227, 2024 | | 2024 |
DOP83 Intestinal epithelium-specific deletion of the Aryl hydrocarbon Receptor (AhR) reduces intestinal Tight Junction permeability thereby hindering homeostatic antigen … K Saha, AS Ganapathy, P Arumugam, A Wang, L Harris, G Yochum, ... Journal of Crohn's and Colitis 18 (Supplement_1), i229-i229, 2024 | | 2024 |
955 ALPHA-TOCOPHERYLQUINONE (TQ) REDUCES INTESTINAL INFLAMMATION BY INHIBITING NFkB AND STAT3 SIGNALING IN AN ARYL HYDROCARBON RECEPTOR (AHR) DEPENDENT MECHANISM K Saha, AS Ganapathy, A Wang, NM Morris, L Harris, GS Yochum, ... Gastroenterology 164 (6), S-209-S-210, 2023 | | 2023 |
282 ALPHA-TOCOPHERYLQUINONE ACTIVATE AHR/NRF2 PATHWAY AND ENHANCES INTESTINAL EPITHELIAL TIGHT JUNCTION BARRIER VIA DIFFERENTIAL MODULATION OF CLAUDINS AS Ganapathy, K Saha, A Wang, V Dharmaprakash, GS Yochum, ... Gastroenterology 164 (6), S-53, 2023 | | 2023 |
664 INTESTINAL EPITHELIA-SPECIFIC DELETION OF ARYL HYDROCARBON RECEPTOR (AHR) REDUCES PARACELLULAR TIGHT JUNCTION PERMEABILITY AND HINDERS IMMUNOGENIC TOLERANCE A Venkatesh, K Saha, AS Ganapathy, A Wang, NM Morris, MT Nighot, ... Gastroenterology 164 (6), S-129, 2023 | | 2023 |
DOP68 Autophagy induction in the intestinal epithelium protects against inflammation-induced barrier loss in vivo. K Saha, AS Ganapathy, A Wang, N Morris, G Yochum, W Koltun, W Ding, ... Journal of Crohn's and Colitis 17 (Supplement_1), i144-i145, 2023 | | 2023 |
596: AP2M1 AND LC3 LIPIDATION GUIDES CLAUDIN-2 INTO AUTOLYSOSOME AS Ganapathy, K Saha, A Wang, MT Nighot, TY Ma, P Nighot Gastroenterology 162 (7), S-149, 2022 | | 2022 |
352: PPI ADMINISTRATION INDUCED COLONIC TIGHT JUNCTION BARRIER DYSFUNCTION IS ASSOCIATED WITH INCREASE IN PH, MLCK AND ENETROCOCCUS FECALIS. NM Morris, K Saha, AS Ganapathy, PK Nighot, K Clarke, TY Ma, ... Gastroenterology 162 (7), S-76, 2022 | | 2022 |