| A clinical-stage cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells DM Mellott, CT Tseng, A Drelich, P Fajtová, BC Chenna, DH Kostomiris, ... ACS chemical biology 16 (4), 642-650, 2021 | 110 | 2021 |
| Potent anti-SARS-CoV-2 activity by the natural product gallinamide A and analogues via inhibition of cathepsin L AS Ashhurst, AH Tang, P Fajtová, MC Yoon, A Aggarwal, MJ Bedding, ... Journal of medicinal chemistry 65 (4), 2956-2970, 2021 | 71* | 2021 |
| A charge‐switchable zwitterionic peptide for rapid detection of SARS‐CoV‐2 main protease Z Jin, Y Mantri, M Retout, Y Cheng, J Zhou, A Jorns, P Fajtova, W Yim, ... Angewandte Chemie 134 (9), e202112995, 2022 | 65 | 2022 |
| Trypsin- and Chymotrypsin-Like Serine Proteases in Schistosoma mansoni – ‘The Undiscovered Country’ M Horn, P Fajtová, L Rojo Arreola, L Ulrychova, P Bartošová-Sojková, ... PLoS neglected tropical diseases 8 (3), e2766, 2014 | 50 | 2014 |
| Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors P Fajtová, S Štefanić, M Hradilek, J Dvořák, J Vondrášek, A Jílková, ... PLoS neglected tropical diseases 9 (6), e0003827, 2015 | 46 | 2015 |
| Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles J Dvořák, P Fajtová, L Ulrychová, A Leontovyč, L Rojo-Arreola, BM Suzuki, ... Biochimie 122, 99-109, 2016 | 44 | 2016 |
| Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch A Jílková, M Horn, P Řezáčová, L Marešová, P Fajtová, J Brynda, ... Structure 22 (12), 1786-1798, 2014 | 42 | 2014 |
| Activatable carbocyanine dimers for photoacoustic and fluorescent detection of protease activity C Moore, RM Borum, Y Mantri, M Xu, P Fajtová, AJ O’Donoghue, ... ACS sensors 6 (6), 2356-2365, 2021 | 38 | 2021 |
| Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease Mpro and Papain-like Protease PLpro of SARS-CoV-2 LH Santos, T Kronenberger, RG Almeida, EB Silva, REO Rocha, ... Journal of Chemical Information and Modeling 62 (24), 6553-6573, 2022 | 34 | 2022 |
| SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties A Leontovyč, L Ulrychová, AJ O’Donoghue, J Vondrášek, L Marešová, ... PLoS neglected tropical diseases 12 (4), e0006446, 2018 | 33 | 2018 |
| Protease-responsive peptide-conjugated mitochondrial-targeting AIEgens for selective imaging and inhibition of SARS-CoV-2-infected cells Y Cheng, AE Clark, J Zhou, T He, Y Li, RM Borum, MN Creyer, M Xu, Z Jin, ... ACS nano 16 (8), 12305-12317, 2022 | 32 | 2022 |
| Native metabolomics identifies the rivulariapeptolide family of protease inhibitors R Reher, AT Aron, P Fajtová, P Stincone, B Wagner, AI Pérez-Lorente, ... Nature communications 13 (1), 4619, 2022 | 31 | 2022 |
| A Dual‐Color Fluorescent Probe Allows Simultaneous Imaging of Main and Papain‐like Proteases of SARS‐CoV‐2‐Infected Cells for Accurate Detection and Rapid Inhibitor Screening Y Cheng, RM Borum, AE Clark, Z Jin, C Moore, P Fajtová, AJ O'Donoghue, ... Angewandte Chemie 134 (9), e202113617, 2022 | 30 | 2022 |
| Large library docking for novel SARS‐CoV‐2 main protease non‐covalent and covalent inhibitors EA Fink, C Bardine, S Gahbauer, I Singh, TC Detomasi, K White, S Gu, ... Protein Science 32 (8), e4712, 2023 | 21 | 2023 |
| Spacer matters: All-peptide-based ligand for promoting interfacial proteolysis and plasmonic coupling Z Jin, C Ling, Y Li, J Zhou, K Li, W Yim, J Yeung, YC Chang, T He, ... Nano Letters 22 (22), 8932-8940, 2022 | 20 | 2022 |
| Peptide Amphiphile Mediated Co‐assembly for Nanoplasmonic Sensing Z Jin, Y Li, K Li, J Zhou, J Yeung, C Ling, W Yim, T He, Y Cheng, M Xu, ... Angewandte Chemie International Edition 62 (4), e202214394, 2023 | 19 | 2023 |
| Peptidic sulfhydryl for interfacing nanocrystals and subsequent sensing of SARS-CoV-2 protease Z Jin, J Yeung, J Zhou, Y Cheng, Y Li, Y Mantri, T He, W Yim, M Xu, Z Wu, ... Chemistry of Materials 34 (3), 1259-1268, 2022 | 19 | 2022 |
| Druggable hot spots in the schistosomiasis cathepsin B1 target identified by functional and binding mode analysis of potent vinyl sulfone inhibitors A Jílková, P Rubešová, J Fanfrlík, P Fajtová, P Řezáčová, J Brynda, ... ACS Infectious Diseases 7 (5), 1077-1088, 2020 | 18 | 2020 |
| Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity A Jílková, M Horn, J Fanfrlik, J Küppers, P Pachl, P Řezáčová, ... ACS Infectious Diseases 7 (1), 189-201, 2020 | 17 | 2020 |
| Empirical optimization of peptide sequence and nanoparticle colloidal stability: The impact of surface ligands and implications for colorimetric sensing Z Jin, J Yeung, J Zhou, M Retout, W Yim, P Fajtová, B Gosselin, I Jabin, ... ACS applied materials & interfaces 15 (16), 20483-20494, 2023 | 15 | 2023 |
