X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease S Günther, PYA Reinke, Y Fernández-García, J Lieske, TJ Lane, HM Ginn, ... Science 372 (6542), 642-646, 2021 | 283 | 2021 |
High-throughput drug discovery: what can we expect from HTS? P Gribbon, S Andreas Drug discovery today 1 (10), 17-22, 2005 | 244 | 2005 |
The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2 S Krasemann, U Haferkamp, S Pfefferle, MS Woo, F Heinrich, ... Stem cell reports 17 (2), 307-320, 2022 | 186 | 2022 |
Fluorescence readouts in HTS: no gain without pain? P Gribbon, A Sewing Drug discovery today 8 (22), 1035-1043, 2003 | 185 | 2003 |
Macromolecular diffusion of biological polymers measured by confocal fluorescence recovery after photobleaching P Gribbon, TE Hardingham Biophysical journal 75 (2), 1032-1039, 1998 | 170 | 1998 |
The molecular basis of the solution properties of hyaluronan investigated by confocal fluorescence recovery after photobleaching P Gribbon, BC Heng, TE Hardingham Biophysical journal 77 (4), 2210-2216, 1999 | 135 | 1999 |
A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection B Ellinger, D Bojkova, A Zaliani, J Cinatl, C Claussen, S Westhaus, ... Scientific data 8 (1), 70, 2021 | 131* | 2021 |
Identification of inhibitors of SARS-CoV-2 3CL-pro enzymatic activity using a small molecule in vitro repurposing screen M Kuzikov, E Costanzi, J Reinshagen, F Esposito, L Vangeel, M Wolf, ... ACS pharmacology & translational science 4 (3), 1096-1110, 2021 | 117 | 2021 |
The analysis of intermolecular interactions in concentrated hyaluronan solutions suggest no evidence for chain–chain association P GRIBBON, BC HENG, TE HARDINGHAM Biochemical Journal 350 (1), 329-335, 2000 | 109 | 2000 |
Alpha-1-acid (AAG, orosomucoid) glycoprotein: interaction with bacterial lipopolysaccharide and protection from sepsis DF Moore, MR Rosenfeld, PM Gribbon, CP Winlove, CM Tsai Inflammation 21, 69-82, 1997 | 99 | 1997 |
Evaluating real-life high-throughput screening data P Gribbon, R Lyons, P Laflin, J Bradley, C Chambers, BS Williams, ... Journal of biomolecular screening 10 (2), 99-107, 2005 | 87 | 2005 |
Measuring intracellular calcium fluxes in high throughput mode C Chambers, F Smith, C Williams, S Marcos, Z Liu, P Hayter, ... Combinatorial chemistry & high throughput screening 6 (4), 355-362, 2003 | 80 | 2003 |
Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC)-the hot start experience PA De Sousa, R Steeg, E Wachter, K Bruce, J King, M Hoeve, S Khadun, ... Stem Cell Research 20, 105-114, 2017 | 64 | 2017 |
Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs C Borsari, R Luciani, C Pozzi, I Poehner, S Henrich, M Trande, ... Journal of medicinal chemistry 59 (16), 7598-7616, 2016 | 52 | 2016 |
Natural compounds inhibit SARS-CoV-2 nsp13 unwinding and ATPase enzyme activities A Corona, K Wycisk, C Talarico, C Manelfi, J Milia, R Cannalire, ... ACS Pharmacology & Translational Science 5 (4), 226-239, 2022 | 51 | 2022 |
The application of confocal microscopy to the study of liposome adsorption onto bacterial biofilms K Ahmed, P Gribbon, MN Jones Journal of liposome research 12 (4), 285-300, 2002 | 51 | 2002 |
A bioluminogenic HDAC activity assay: validation and screening F Halley, J Reinshagen, B Ellinger, M Wolf, AL Niles, NJ Evans, ... Journal of biomolecular screening 16 (10), 1227-1235, 2011 | 50 | 2011 |
Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets H Lempiäinen, I Brænne, T Michoel, V Tragante, B Vilne, TR Webb, ... Scientific reports 8 (1), 3434, 2018 | 47 | 2018 |
A blueprint for high affinity SARS-CoV-2 Mpro inhibitors from activity-based compound library screening guided by analysis of protein dynamics J Gossen, S Albani, A Hanke, BP Joseph, C Bergh, M Kuzikov, E Costanzi, ... ACS pharmacology & translational science 4 (3), 1079-1095, 2021 | 46 | 2021 |
Feasibility study using surface-enhanced Raman spectroscopy for the quantitative detection of tyrosine and serine phosphorylation J Moger, P Gribbon, A Sewing, CP Winlove Biochimica et Biophysica Acta (BBA)-General Subjects 1770 (6), 912-918, 2007 | 44 | 2007 |