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Daniel Sutherlin
Daniel Sutherlin
在 gene.com 的电子邮件经过验证
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引用次数
引用次数
年份
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
TR Wilson, J Fridlyand, Y Yan, E Penuel, L Burton, E Chan, J Peng, E Lin, ...
Nature 487 (7408), 505-509, 2012
13342012
GDC-0449—A potent inhibitor of the hedgehog pathway
KD Robarge, SA Brunton, GM Castanedo, Y Cui, MS Dina, R Goldsmith, ...
Bioorganic & medicinal chemistry letters 19 (19), 5576-5581, 2009
4632009
Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance
GJP Dijkgraaf, B Alicke, L Weinmann, T Januario, K West, Z Modrusan, ...
Cancer research 71 (2), 435-444, 2011
4222011
Synthesis and application of functionally diverse 2, 6, 9-trisubstituted purine libraries as CDK inhibitors
YT Chang, NS Gray, GR Rosania, DP Sutherlin, S Kwon, TC Norman, ...
Chemistry & biology 6 (6), 361-375, 1999
3901999
Structural basis of Nav1. 7 inhibition by an isoform-selective small-molecule antagonist
S Ahuja, S Mukund, L Deng, K Khakh, E Chang, H Ho, S Shriver, C Young, ...
Science 350 (6267), aac5464, 2015
3302015
GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway
JJ Wallin, KA Edgar, J Guan, M Berry, WW Prior, L Lee, JD Lesnick, ...
Molecular cancer therapeutics 10 (12), 2426-2436, 2011
2962011
Myoseverin, a microtubule-binding molecule with novel cellular effects
GR Rosania, YT Chang, O Perez, D Sutherlin, H Dong, DJ Lockhart, ...
Nature biotechnology 18 (3), 304-308, 2000
2672000
Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the …
DP Sutherlin, L Bao, M Berry, G Castanedo, I Chuckowree, J Dotson, ...
Journal of medicinal chemistry 54 (21), 7579-7587, 2011
2312011
A method for directed evolution and functional cloning of enzymes
H Pedersen, S Hölder, DP Sutherlin, U Schwitter, DS King, PG Schultz
Proceedings of the National Academy of Sciences 95 (18), 10523-10528, 1998
2291998
Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity
CY Edosada, C Quan, C Wiesmann, T Tran, D Sutherlin, M Reynolds, ...
Journal of Biological Chemistry 281 (11), 7437-7444, 2006
1822006
Fibroblast activation protein cleaves and inactivates fibroblast growth factor 21
DR Dunshee, TW Bainbridge, NM Kljavin, J Zavala-Solorio, ...
Journal of Biological Chemistry 291 (11), 5986-5996, 2016
1512016
Discovery of (thienopyrimidin-2-yl) aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer
DP Sutherlin, D Sampath, M Berry, G Castanedo, Z Chang, I Chuckowree, ...
Journal of medicinal chemistry 53 (3), 1086-1097, 2010
1482010
Generation of C-glycoside peptide ligands for cell surface carbohydrate receptors using a four-component condensation on solid support
DP Sutherlin, TM Stark, R Hughes, RW Armstrong
The Journal of organic chemistry 61 (23), 8350-8354, 1996
1311996
In vitro sulfotransferase activity of NodH, a nodulation protein of Rhizobium meliloti required for host-specific nodulation
DW Ehrhardt, EM Atkinson, KF Faull, DI Freedberg, DP Sutherlin, ...
Journal of Bacteriology 177 (21), 6237-6245, 1995
1221995
Synthesis of tetrasubstituted thiophenes on solid-support using the Gewald reaction
GM Castanedo, DP Sutherlin
Tetrahedron Letters 42 (41), 7181-7184, 2001
1002001
Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor
TP Heffron, M Berry, G Castanedo, C Chang, I Chuckowree, J Dotson, ...
Bioorganic & medicinal chemistry letters 20 (8), 2408-2411, 2010
972010
Inhibition and reversal of myogenic differentiation by purine-based microtubule assembly inhibitors
OD Perez, YT Chang, G Rosania, D Sutherlin, PG Schultz
Chemistry & biology 9 (4), 475-483, 2002
952002
Rational design of phosphoinositide 3-kinase α inhibitors that exhibit selectivity over the phosphoinositide 3-kinase β isoform
TP Heffron, BQ Wei, A Olivero, ST Staben, V Tsui, S Do, J Dotson, ...
Journal of medicinal chemistry 54 (22), 7815-7833, 2011
832011
Discovery and preclinical development of vismodegib
SE Gould, JA Low, JC Marsters Jr, K Robarge, LL Rubin, FJ de Sauvage, ...
Expert opinion on drug discovery 9 (8), 969-984, 2014
792014
Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models
T Focken, S Liu, N Chahal, M Dauphinais, ME Grimwood, S Chowdhury, ...
ACS medicinal chemistry letters 7 (3), 277-282, 2016
782016
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