| Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade CE Bulawa, S Connelly, M DeVit, L Wang, C Weigel, JA Fleming, ... Proceedings of the National Academy of Sciences 109 (24), 9629-9634, 2012 | 733 | 2012 |
| Prevention of transthyretin amyloid disease by changing protein misfolding energetics P Hammarstrom, RL Wiseman, ET Powers, JW Kelly Science 299 (5607), 713-716, 2003 | 602 | 2003 |
| Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments MD Shoulders, LM Ryno, JC Genereux, JJ Moresco, PG Tu, C Wu, ... Cell reports 3 (4), 1279-1292, 2013 | 539 | 2013 |
| The biological and chemical basis for tissue-selective amyloid disease Y Sekijima, RL Wiseman, J Matteson, P Hammarström, SR Miller, ... Cell 121 (1), 73-85, 2005 | 529 | 2005 |
| Targeting protein aggregation for the treatment of degenerative diseases YS Eisele, C Monteiro, C Fearns, SE Encalada, RL Wiseman, ET Powers, ... Nature reviews Drug discovery 14 (11), 759-780, 2015 | 422 | 2015 |
| Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses SM Johnson, RL Wiseman, Y Sekijima, NS Green, SL Adamski-Werner, ... Accounts of chemical research 38 (12), 911-921, 2005 | 345 | 2005 |
| Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action H Razavi, SK Palaninathan, ET Powers, RL Wiseman, HE Purkey, ... Angewandte Chemie 115 (24), 2864-2867, 2003 | 285 | 2003 |
| Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation L Plate, CB Cooley, JJ Chen, RJ Paxman, CM Gallagher, F Madoux, ... elife 5, e15550, 2016 | 213 | 2016 |
| Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1 RL Wiseman, Y Zhang, KPK Lee, HP Harding, CM Haynes, J Price, ... Molecular cell 38 (2), 291-304, 2010 | 212 | 2010 |
| The pathway by which the tetrameric protein transthyretin dissociates TR Foss, RL Wiseman, JW Kelly Biochemistry 44 (47), 15525-15533, 2005 | 211 | 2005 |
| The PERK arm of the unfolded protein response regulates mitochondrial morphology during acute endoplasmic reticulum stress J Lebeau, JM Saunders, VWR Moraes, A Madhavan, N Madrazo, ... Cell reports 22 (11), 2827-2836, 2018 | 209 | 2018 |
| Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing C Puchades, AJ Rampello, M Shin, CJ Giuliano, RL Wiseman, SE Glynn, ... Science 358 (6363), eaao0464, 2017 | 204 | 2017 |
| Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics A Carreras-Sureda, F Jana, H Urra, S Durand, DE Mortenson, A Sagredo, ... Nature cell biology 21 (6), 755-767, 2019 | 197 | 2019 |
| Stress-responsive regulation of mitochondria through the ER unfolded protein response TK Rainbolt, JM Saunders, RL Wiseman Trends in Endocrinology & Metabolism 25 (10), 528-537, 2014 | 197 | 2014 |
| Stress-regulated translational attenuation adapts mitochondrial protein import through Tim17A degradation TK Rainbolt, N Atanassova, JC Genereux, RL Wiseman Cell metabolism 18 (6), 908-919, 2013 | 183 | 2013 |
| An adaptable standard for protein export from the endoplasmic reticulum RL Wiseman, ET Powers, JN Buxbaum, JW Kelly, WE Balch Cell 131 (4), 809-821, 2007 | 177 | 2007 |
| Reciprocal degradation of YME1L and OMA1 adapts mitochondrial proteolytic activity during stress TK Rainbolt, J Lebeau, C Puchades, RL Wiseman Cell reports 14 (9), 2041-2049, 2016 | 171 | 2016 |
| Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis EA Blackwood, K Azizi, DJ Thuerauf, RJ Paxman, L Plate, JW Kelly, ... Nature communications 10 (1), 187, 2019 | 161 | 2019 |
| D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis? P Hammarström, Y Sekijima, JT White, RL Wiseman, A Lim, CE Costello, ... Biochemistry 42 (22), 6656-6663, 2003 | 158 | 2003 |
| Unfolded protein response‐induced ER dj3 secretion links ER stress to extracellular proteostasis JC Genereux, S Qu, M Zhou, LM Ryno, S Wang, MD Shoulders, ... The EMBO journal 34 (1), 4-19, 2015 | 145 | 2015 |
