Organoid models of human and mouse ductal pancreatic cancer SF Boj, CI Hwang, LA Baker, IIC Chio, DD Engle, V Corbo, M Jager, ... Cell 160 (1), 324-338, 2015 | 1943 | 2015 |
SARS-CoV-2 productively infects human gut enterocytes MM Lamers, J Beumer, J van der Vaart, K Knoops, J Puschhof, ... Science 369 (6499), 50-54, 2020 | 1736 | 2020 |
Phylogenetic shadowing and computational identification of human microRNA genes E Berezikov, V Guryev, J van de Belt, E Wienholds, RHA Plasterk, ... Cell 120 (1), 21-24, 2005 | 1703 | 2005 |
Sambamba: fast processing of NGS alignment formats A Tarasov, AJ Vilella, E Cuppen, IJ Nijman, P Prins Bioinformatics 31 (12), 2032-2034, 2015 | 1640 | 2015 |
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients G Schwank, BK Koo, V Sasselli, JF Dekkers, I Heo, T Demircan, N Sasaki, ... Cell stem cell 13 (6), 653-658, 2013 | 1628 | 2013 |
A living biobank of breast cancer organoids captures disease heterogeneity N Sachs, J De Ligt, O Kopper, E Gogola, G Bounova, F Weeber, ... Cell 172 (1), 373-386. e10, 2018 | 1527 | 2018 |
Long-term culture of genome-stable bipotent stem cells from adult human liver M Huch, H Gehart, R Van Boxtel, K Hamer, F Blokzijl, MMA Verstegen, ... Cell 160 (1), 299-312, 2015 | 1485 | 2015 |
Mammalian mirtron genes E Berezikov, WJ Chung, J Willis, E Cuppen, EC Lai Molecular cell 28 (2), 328-336, 2007 | 1104 | 2007 |
Sequential cancer mutations in cultured human intestinal stem cells J Drost, RH Van Jaarsveld, B Ponsioen, C Zimberlin, R Van Boxtel, ... Nature 521 (7550), 43-47, 2015 | 1072 | 2015 |
Tissue-specific mutation accumulation in human adult stem cells during life F Blokzijl, J De Ligt, M Jager, V Sasselli, S Roerink, N Sasaki, M Huch, ... Nature 538 (7624), 260-264, 2016 | 897 | 2016 |
Pan-cancer whole-genome analyses of metastatic solid tumours P Priestley, J Baber, MP Lolkema, N Steeghs, E de Bruijn, C Shale, ... Nature 575 (7781), 210-216, 2019 | 833 | 2019 |
Long‐term expanding human airway organoids for disease modeling N Sachs, A Papaspyropoulos, DD Zomer‐van Ommen, I Heo, L Böttinger, ... The EMBO journal 38 (4), e100300, 2019 | 798 | 2019 |
Identification of multipotent luminal progenitor cells in human prostate organoid cultures WR Karthaus, PJ Iaquinta, J Drost, A Gracanin, R Van Boxtel, J Wongvipat, ... Cell 159 (1), 163-175, 2014 | 727 | 2014 |
Mutational signature in colorectal cancer caused by genotoxic pks+E. coli C Pleguezuelos-Manzano, J Puschhof, A Rosendahl Huber, A van Hoeck, ... Nature 580 (7802), 269-273, 2020 | 726 | 2020 |
A systematic genome-wide analysis of zebrafish protein-coding gene function RNW Kettleborough, EM Busch-Nentwich, SA Harvey, CM Dooley, ... Nature 496 (7446), 494-497, 2013 | 704 | 2013 |
Diversity of microRNAs in human and chimpanzee brain E Berezikov, F Thuemmler, LW Van Laake, I Kondova, R Bontrop, ... Nature genetics 38 (12), 1375-1377, 2006 | 631 | 2006 |
Approaches to microRNA discovery E Berezikov, E Cuppen, RHA Plasterk Nature genetics 38 (Suppl 6), S2-S7, 2006 | 614 | 2006 |
The microRNA-producing enzyme Dicer1 is essential for zebrafish development E Wienholds, MJ Koudijs, FJM van Eeden, E Cuppen, RHA Plasterk Nature genetics 35 (3), 217-218, 2003 | 605 | 2003 |
MutationalPatterns: comprehensive genome-wide analysis of mutational processes F Blokzijl, R Janssen, R Van Boxtel, E Cuppen Genome medicine 10, 1-11, 2018 | 584 | 2018 |
Efficient target-selected mutagenesis in zebrafish E Wienholds, F van Eeden, M Kosters, J Mudde, RHA Plasterk, E Cuppen Genome research 13 (12), 2700-2707, 2003 | 561 | 2003 |