Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin T Masuda, X Wang, M Maeda, MC Canver, F Sher, APW Funnell, C Fisher, ... Science 351 (6270), 285-289, 2016 | 334 | 2016 |
Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding GE Martyn, B Wienert, L Yang, M Shah, LJ Norton, J Burdach, R Kurita, ... Nature genetics 50 (4), 498-503, 2018 | 264 | 2018 |
Targeted Disruption of the Basic Krüppel-Like Factor Gene (Klf3) Reveals a Role in Adipogenesis N Sue, BHA Jack, SA Eaton, RCM Pearson, APW Funnell, J Turner, ... Molecular and cellular biology 28 (12), 3967-3978, 2008 | 220 | 2008 |
Holding tight: cell junctions and cancer spread AJ Knights, APW Funnell, M Crossley, RCM Pearson Trends in cancer research 8, 61, 2012 | 152 | 2012 |
Positively selected enhancer elements endow osteosarcoma cells with metastatic competence JJ Morrow, I Bayles, APW Funnell, TE Miller, A Saiakhova, MM Lizardo, ... Nature medicine 24 (2), 176-185, 2018 | 146 | 2018 |
A Network of Krüppel-like Factors (Klfs): Klf8 is repressed by Klf3 and activated by Klf1 in vivo SA Eaton, APW Funnell, N Sue, H Nicholas, RCM Pearson, M Crossley Journal of Biological Chemistry 283 (40), 26937-26947, 2008 | 132 | 2008 |
Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin B Wienert, APW Funnell, LJ Norton, RCM Pearson, LE Wilkinson-White, ... Nature communications 6 (1), 7085, 2015 | 130 | 2015 |
Adipokines and insulin action: A sensitive issue AJ Knights, APW Funnell, RCM Pearson, M Crossley, KS Bell-Anderson Adipocyte 3 (2), 88-96, 2014 | 121 | 2014 |
Erythroid Kruppel-like factor directly activates the basic Kruppel-like factor gene in erythroid cells APW Funnell, CA Maloney, LJ Thompson, J Keys, M Tallack, AC Perkins, ... Molecular and cellular biology 27 (7), 2777-2790, 2007 | 116 | 2007 |
Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways B Ballester, A Medina-Rivera, D Schmidt, M Gonzàlez-Porta, M Carlucci, ... Elife 3, e02626, 2014 | 115 | 2014 |
Wake-up sleepy gene: reactivating fetal globin for β-hemoglobinopathies B Wienert, GE Martyn, APW Funnell, KGR Quinlan, M Crossley Trends in Genetics 34 (12), 927-940, 2018 | 113 | 2018 |
PU. 1 and haematopoietic cell fate: dosage matters KS Mak, APW Funnell, RCM Pearson, M Crossley International journal of cell biology 2011 (1), 808524, 2011 | 101 | 2011 |
The mammalian zinc finger transcription factor Krüppel‐like factor 3 (KLF3/BKLF) RCM Pearson, APW Funnell, M Crossley IUBMB life 63 (2), 86-93, 2011 | 80 | 2011 |
2p15-p16.1 microdeletions encompassing and proximal to BCL11A are associated with elevated HbF in addition to neurologic impairment APW Funnell, P Prontera, V Ottaviani, M Piccione, A Giambona, A Maggio, ... Blood, The Journal of the American Society of Hematology 126 (1), 89-93, 2015 | 78 | 2015 |
Homo-and heterodimerization in transcriptional regulation APW Funnell, M Crossley Protein Dimerization and Oligomerization in Biology, 105-121, 2012 | 74 | 2012 |
KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells LJ Norton, APW Funnell, J Burdach, B Wienert, R Kurita, Y Nakamura, ... Blood advances 1 (11), 685-692, 2017 | 66 | 2017 |
The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo APW Funnell, LJ Norton, KS Mak, J Burdach, CM Artuz, NA Twine, ... Molecular and cellular biology, 2012 | 56 | 2012 |
Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing APW Funnell, KS Mak, NA Twine, GJ Pelka, LJ Norton, T Radziewic, ... Molecular and cellular biology 33 (15), 2976-2987, 2013 | 55 | 2013 |
Loss of Krüppel-like factor 3 (KLF3/BKLF) leads to upregulation of the insulin-sensitizing factor adipolin (FAM132A/CTRP12/C1qdc2) KS Bell-Anderson, AP Funnell, H Williams, H Mat Jusoh, T Scully, WF Lim, ... Diabetes 62 (8), 2728-2737, 2013 | 54 | 2013 |
Impaired B cell development in the absence of Krüppel-like factor 3 TT Vu, D Gatto, V Turner, APW Funnell, KS Mak, LJ Norton, W Kaplan, ... The Journal of Immunology 187 (10), 5032-5042, 2011 | 52 | 2011 |