Mitragynine/corynantheidine pseudoindoxyls as opioid analgesics with mu agonism and delta antagonism, which do not recruit β-arrestin-2 A Váradi, GF Marrone, TC Palmer, A Narayan, MR Szabó, V Le Rouzic, ... Journal of medicinal chemistry 59 (18), 8381-8397, 2016 | 315 | 2016 |
Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators AC Kruegel, MM Gassaway, A Kapoor, A Váradi, S Majumdar, M Filizola, ... Journal of the American Chemical Society 138 (21), 6754-6764, 2016 | 308 | 2016 |
Isocyanide-based multicomponent reactions for the synthesis of heterocycles A Váradi, TC Palmer, R Notis Dardashti, S Majumdar Molecules 21 (1), 19, 2015 | 166 | 2015 |
Detection and identification of the new potential synthetic cannabinoids 1-pentyl-3-(2-iodobenzoyl) indole and 1-pentyl-3-(1-adamantoyl) indole in seized bulk powders in Hungary P Jankovics, A Váradi, L Tölgyesi, S Lohner, J Németh-Palotás, J Balla Forensic science international 214 (1-3), 27-32, 2012 | 106 | 2012 |
Identification and characterization of the new designer drug 4′-methylethcathinone (4-MEC) and elaboration of a novel liquid chromatography–tandem mass spectrometry (LC–MS/MS … P Jankovics, A Váradi, L Tölgyesi, S Lohner, J Németh-Palotás, ... Forensic science international 210 (1-3), 213-220, 2011 | 99 | 2011 |
Synthesis and characterization of a dual kappa-delta opioid receptor agonist analgesic blocking cocaine reward behavior A Váradi, GF Marrone, SO Eans, ML Ganno, JJ Subrath, V Le Rouzic, ... ACS chemical neuroscience 6 (11), 1813-1824, 2015 | 61 | 2015 |
Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site R Uprety, T Che, SA Zaidi, SG Grinnell, BR Varga, A Faouzi, ST Slocum, ... Elife 10, e56519, 2021 | 56 | 2021 |
Synthesis of carfentanil amide opioids using the Ugi multicomponent reaction A Váradi, TC Palmer, N Haselton, D Afonin, JJ Subrath, V Le Rouzic, ... ACS chemical neuroscience 6 (9), 1570-1577, 2015 | 53 | 2015 |
Oxidative metabolism as a modulator of kratom’s biological actions S Chakraborty, R Uprety, ST Slocum, T Irie, V Le Rouzic, X Li, LL Wilson, ... Journal of medicinal chemistry 64 (22), 16553-16572, 2021 | 40 | 2021 |
A non-retinoid antagonist of retinol-binding protein 4 rescues phenotype in a model of Stargardt disease without inhibiting the visual cycle B Racz, A Varadi, J Kong, R Allikmets, PG Pearson, G Johnson, CL Cioffi, ... Journal of Biological Chemistry 293 (29), 11574-11588, 2018 | 40 | 2018 |
A novel µ-opioid receptor ligand with high in vitro and in vivo agonist efficacy E Lacko, A Varadi, R Rapavi, F Zador, P Riba, S Benyhe, A Borsodi, ... Current medicinal chemistry 19 (27), 4699-4707, 2012 | 32 | 2012 |
Three-component coupling approach for the synthesis of diverse heterocycles utilizing reactive nitrilium trapping A Varadi, TC Palmer, PR Notis, GN Redel-Traub, D Afonin, JJ Subrath, ... Organic letters 16 (6), 1668-1671, 2014 | 28 | 2014 |
Design, synthesis, and preclinical efficacy of novel nonretinoid antagonists of retinol-binding protein 4 in the mouse model of hepatic steatosis CL Cioffi, B Racz, A Varadi, EE Freeman, MP Conlon, P Chen, L Zhu, ... Journal of medicinal chemistry 62 (11), 5470-5500, 2019 | 27 | 2019 |
Mild, Pd-catalyzed stannylation of radioiodination targets JE Pickett, A Váradi, TC Palmer, SG Grinnell, JM Schrock, GW Pasternak, ... Bioorganic & medicinal chemistry letters 25 (8), 1761-1764, 2015 | 25 | 2015 |
New morphine analogs produce peripheral antinociception within a certain dose range of their systemic administration E Lackó, P Riba, Z Giricz, A Váradi, L Cornic, M Balogh, K Király, ... Journal of Pharmacology and Experimental Therapeutics 359 (1), 171-181, 2016 | 23 | 2016 |
Synthesis and configurational assignment of 1, 2-dihydroimidazo [5, 1-b] quinazoline-3, 9-diones: novel NMDA receptor antagonists A Váradi, P Horváth, T Kurtán, A Mándi, G Tóth, A Gergely, J Kökösi Tetrahedron 68 (50), 10365-10371, 2012 | 23 | 2012 |
Novel 6β-acylaminomorphinans with analgesic activity A Váradi, S Hosztafi, V Le Rouzic, G Tóth, Á Urai, B Noszál, ... European journal of medicinal chemistry 69, 786-789, 2013 | 22 | 2013 |
Sulfate esters of morphine derivatives: Synthesis and characterization A Váradi, A Gergely, S Béni, P Jankovics, B Noszál, S Hosztafi European journal of pharmaceutical sciences 42 (1-2), 65-72, 2011 | 22 | 2011 |
Genetic dissociation of morphine analgesia from hyperalgesia in mice GF Marrone, V Le Rouzic, A Varadi, J Xu, AM Rajadhyaksha, S Majumdar, ... Psychopharmacology 234, 1891-1900, 2017 | 21 | 2017 |
The mixed kappa and delta opioid receptor agonist, MP1104, attenuates chemotherapy-induced neuropathic pain DV Atigari, KF Paton, R Uprety, A Váradi, AF Alder, B Scouller, JH Miller, ... Neuropharmacology 185, 108445, 2021 | 15 | 2021 |