| Semi-rational approaches to engineering enzyme activity: combining the benefits of directed evolution and rational design RA Chica, N Doucet, JN Pelletier Current opinion in biotechnology 16 (4), 378-384, 2005 | 730 | 2005 |
| The end of an old hypothesis: the Pseudomonas signaling molecules 4-hydroxy-2-alkylquinolines derive from fatty acids, not 3-ketofatty acids CE Dulcey, V Dekimpe, DA Fauvelle, S Milot, MC Groleau, N Doucet, ... Chemistry & biology 20 (12), 1481-1491, 2013 | 152 | 2013 |
| The flexibility of a distant loop modulates active site motion and product release in ribonuclease A N Doucet, ED Watt, JP Loria Biochemistry 48 (30), 7160-7168, 2009 | 95 | 2009 |
| Incorporation of manganese complexes into xylanase: new artificial metalloenzymes for enantioselective epoxidation M Allard, C Dupont, V Munoz Robles, N Doucet, A Lledós, JD Maréchal, ... ChemBioChem 13 (2), 240-251, 2012 | 91 | 2012 |
| Site-saturation mutagenesis of Tyr-105 reveals its importance in substrate stabilization and discrimination in TEM-1 β-lactamase N Doucet, PY De Wals, JN Pelletier Journal of Biological Chemistry 279 (44), 46295-46303, 2004 | 70 | 2004 |
| Combining chitinase C and N-acetylhexosaminidase from Streptomyces coelicolor A3 (2) provides an efficient way to synthesize N-acetylglucosamine from crystalline chitin N Nguyen-Thi, N Doucet Journal of Biotechnology 220, 25-32, 2016 | 66 | 2016 |
| Short-chain flavor ester synthesis in organic media by an E. coli whole-cell biocatalyst expressing a newly characterized heterologous lipase G Brault, F Shareck, Y Hurtubise, F Lépine, N Doucet PLoS One 9 (3), e91872, 2014 | 65 | 2014 |
| Cytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells AA Grosset, M Labrie, D Gagné, MC Vladoiu, L Gaboury, N Doucet, ... BMC cancer 14, 1-10, 2014 | 59 | 2014 |
| Isolation and Characterization of EstC, a New Cold-Active Esterase from Streptomyces coelicolor A3(2) G Brault, F Shareck, Y Hurtubise, F Lépine, N Doucet PloS one 7 (3), e32041, 2012 | 53 | 2012 |
| NMR investigation of Tyr105 mutants in TEM-1 β-lactamase: dynamics are correlated with function N Doucet, PY Savard, JN Pelletier Journal of Biological Chemistry 282 (29), 21448-21459, 2007 | 51 | 2007 |
| Conservation of flexible residue clusters among structural and functional enzyme homologues D Gagné, LA Charest, S Morin, EL Kovrigin, N Doucet Journal Of Biological Chemistry 287 (53), 44289-44300, 2012 | 46 | 2012 |
| Conservation of dynamics associated with biological function in an enzyme superfamily C Narayanan, DN Bernard, K Bafna, D Gagné, CS Chennubhotla, ... Structure 26 (3), 426-436. e3, 2018 | 44 | 2018 |
| Perturbation of the conformational dynamics of an active-site loop alters enzyme activity D Gagné, RL French, C Narayanan, M Simonović, PK Agarwal, N Doucet Structure 23 (12), 2256-2266, 2015 | 42 | 2015 |
| Structural and functional importance of local and global conformational fluctuations in the RN ase A superfamily D Gagné, N Doucet The FEBS journal 280 (22), 5596-5607, 2013 | 42 | 2013 |
| Applications of NMR and computational methodologies to study protein dynamics C Narayanan, K Bafna, LD Roux, PK Agarwal, N Doucet Archives of biochemistry and biophysics 628, 71-80, 2017 | 39 | 2017 |
| Synthesis and biological assessment of a ruthenium (II) cyclopentadienyl complex in breast cancer cells and on the development of zebrafish embryos G Golbaghi, I Pitard, M Lucas, MM Haghdoost, YL de Los Santos, ... European journal of medicinal chemistry 188, 112030, 2020 | 38 | 2020 |
| Conformational sub-states and populations in enzyme catalysis PK Agarwal, N Doucet, C Chennubhotla, A Ramanathan, C Narayanan Methods in enzymology 578, 273-297, 2016 | 38 | 2016 |
| Maintenance of native-like protein dynamics may not be required for engineering functional proteins SMC Gobeil, CM Clouthier, J Park, D Gagné, AM Berghuis, N Doucet, ... Chemistry & biology 21 (10), 1330-1340, 2014 | 38 | 2014 |
| Alteration of hydrogen bonding in the vicinity of histidine 48 disrupts millisecond motions in RNase A N Doucet, G Khirich, EL Kovrigin, JP Loria Biochemistry 50 (10), 1723-1730, 2011 | 38 | 2011 |
| Direct phosphorylation of SRC homology 3 domains by tyrosine kinase receptors disassembles ligand-induced signaling networks U Dionne, FJM Chartier, YL de Los Santos, N Lavoie, DN Bernard, ... Molecular cell 70 (6), 995-1007. e11, 2018 | 37 | 2018 |
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