Hypoxia and hypoxia-inducible factors: Master regulators of metastasishypoxia and HIFs in cancer metastasis X Lu, Y Kang Clinical cancer research 16 (24), 5928-5935, 2010 | 802 | 2010 |
VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors X Lu, E Mu, Y Wei, S Riethdorf, Q Yang, M Yuan, J Yan, Y Hua, BJ Tiede, ... Cancer cell 20 (6), 701-714, 2011 | 556 | 2011 |
Targeting YAP-dependent MDSC infiltration impairs tumor progression G Wang, X Lu, P Dey, P Deng, CC Wu, S Jiang, Z Fang, K Zhao, ... Cancer discovery 6 (1), 80-95, 2016 | 502 | 2016 |
Effective combinatorial immunotherapy for castration-resistant prostate cancer X Lu, JW Horner, E Paul, X Shang, P Troncoso, P Deng, S Jiang, ... Nature 543 (7647), 728-732, 2017 | 487 | 2017 |
ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis X Lu, Q Wang, G Hu, C Van Poznak, M Fleisher, M Reiss, J Massagué, ... Genes & development 23 (16), 1882-1894, 2009 | 362 | 2009 |
Organotropism of breast cancer metastasis X Lu, Y Kang Journal of mammary gland biology and neoplasia 12, 153-162, 2007 | 318 | 2007 |
Chemokine (CC motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone X Lu, Y Kang Journal of biological chemistry 284 (42), 29087-29096, 2009 | 286 | 2009 |
Imaging transforming growth factor-β signaling dynamics and therapeutic response in breast cancer bone metastasis M Korpal, J Yan, X Lu, S Xu, DA Lerit, Y Kang Nature medicine 15 (8), 960-966, 2009 | 260 | 2009 |
Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases Z Ding, CJ Wu, M Jaskelioff, E Ivanova, M Kost-Alimova, A Protopopov, ... Cell 148 (5), 896-907, 2012 | 253 | 2012 |
Epigenetic activation of WNT5A drives glioblastoma stem cell differentiation and invasive growth B Hu, Q Wang, YA Wang, S Hua, CEG Sauvé, D Ong, ZD Lan, Q Chang, ... Cell 167 (5), 1281-1295. e18, 2016 | 248 | 2016 |
Cell Fusion as a Hidden Force in Tumor ProgressionCell Fusion in Tumor Progression X Lu, Y Kang Cancer research 69 (22), 8536-8539, 2009 | 229 | 2009 |
Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer D Zhao, X Lu, G Wang, Z Lan, W Liao, J Li, X Liang, JR Chen, S Shah, ... Nature 542 (7642), 484-488, 2017 | 192 | 2017 |
Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis Y Liang, H Wu, R Lei, RA Chong, Y Wei, X Lu, I Tagkopoulos, SY Kung, ... Journal of Biological Chemistry 287 (40), 33533-33544, 2012 | 141 | 2012 |
Efficient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants X Lu, Y Kang Proceedings of the National Academy of Sciences 106 (23), 9385-9390, 2009 | 130 | 2009 |
Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers S Feng, X Cheng, L Zhang, X Lu, S Chaudhary, R Teng, C Frederickson, ... Proceedings of the National Academy of Sciences 115 (40), 10094-10099, 2018 | 126 | 2018 |
MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene-and carcinogen-induced mammary tumors L Wan, X Lu, S Yuan, Y Wei, F Guo, M Shen, M Yuan, R Chakrabarti, ... Cancer cell 26 (1), 92-105, 2014 | 126 | 2014 |
Metabolomic changes accompanying transformation and acquisition of metastatic potential in a syngeneic mouse mammary tumor model X Lu, B Bennet, E Mu, J Rabinowitz, Y Kang Journal of Biological Chemistry 285 (13), 9317-9321, 2010 | 110 | 2010 |
In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer X Lu, CH Yan, M Yuan, Y Wei, G Hu, Y Kang Cancer research 70 (10), 3905-3914, 2010 | 103 | 2010 |
Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo X Zhang, J Tamasi, X Lu, J Zhu, H Chen, X Tian, TC Lee, DW Threadgill, ... Journal of Bone and Mineral Research 26 (5), 1022-1034, 2011 | 89 | 2011 |
STAT3 inhibition combined with CpG immunostimulation activates antitumor immunity to eradicate genetically distinct castration-resistant prostate cancers D Moreira, T Adamus, X Zhao, YL Su, Z Zhang, SV White, P Swiderski, ... Clinical Cancer Research 24 (23), 5948-5962, 2018 | 80 | 2018 |