The benefits of the multi-target approach in drug design and discovery LM Espinoza-Fonseca Bioorganic & medicinal chemistry 14 (4), 896-897, 2006 | 174 | 2006 |
Reconciling binding mechanisms of intrinsically disordered proteins LM Espinoza-Fonseca Biochemical and biophysical research communications 382 (3), 479-482, 2009 | 113 | 2009 |
Phosphorylation-induced structural changes in smooth muscle myosin regulatory light chain D Kast, LM Espinoza-Fonseca, C Yi, DD Thomas Proceedings of the National Academy of Sciences 107 (18), 8207-8212, 2010 | 94 | 2010 |
Docking and quantum mechanic studies on cholinesterases and their inhibitors J Correa-Basurto, C Flores-Sandoval, J Marín-Cruz, A Rojo-Domínguez, ... European journal of medicinal chemistry 42 (1), 10-19, 2007 | 76 | 2007 |
Molecular dynamics simulations reveal a disorder-to-order transition on phosphorylation of smooth muscle myosin LM Espinoza-Fonseca, D Kast, DD Thomas Biophysical journal 93 (6), 2083-2090, 2007 | 73 | 2007 |
Synthesis, anticholinesterase activity and structure–activity relationships of m-aminobenzoic acid derivatives J Trujillo-Ferrara, LM Cano, M Espinoza-Fonseca Bioorganic & medicinal chemistry letters 13 (10), 1825-1827, 2003 | 68 | 2003 |
Thermodynamic and structural basis of phosphorylation-induced disorder-to-order transition in the regulatory light chain of smooth muscle myosin LM Espinoza-Fonseca, D Kast, DD Thomas Journal of the American Chemical Society 130 (37), 12208-12209, 2008 | 67 | 2008 |
Atomic-level characterization of the activation mechanism of SERCA by calcium LM Espinoza-Fonseca, DD Thomas PLoS One 6 (10), e26936, 2011 | 65 | 2011 |
Site-directed spectroscopy of cardiac myosin-binding protein C reveals effects of phosphorylation on protein structural dynamics BA Colson, AR Thompson, LM Espinoza-Fonseca, DD Thomas Proceedings of the National Academy of Sciences 113 (12), 3233-3238, 2016 | 58 | 2016 |
Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer LM Espinoza-Fonseca Theoretical Biology and Medical Modelling 2, 1-6, 2005 | 56 | 2005 |
p–Aminobenzoic acid derivatives as acetylcholinesterase inhibitors J Correa-Basurto, IV Alcántara, LM Espinoza-Fonseca, JG Trujillo-Ferrara European journal of medicinal chemistry 40 (7), 732-735, 2005 | 56 | 2005 |
Conformational changes of the p53‐binding cleft of MDM2 revealed by molecular dynamics simulations LM Espinoza‐Fonseca, JG Trujillo‐Ferrara Biopolymers: Original Research on Biomolecules 83 (4), 365-373, 2006 | 53 | 2006 |
Linking biochemical and structural states of SERCA: achievements, challenges, and new opportunities R Aguayo-Ortiz, LM Espinoza-Fonseca International Journal of Molecular Sciences 21 (11), 4146, 2020 | 48 | 2020 |
Sarcolipin Promotes Uncoupling of the SERCA Ca2+ Pump by Inducing a Structural Rearrangement in the Energy-Transduction Domain JM Autry, DD Thomas, LM Espinoza-Fonseca Biochemistry 55 (44), 6083-6086, 2016 | 45 | 2016 |
Microsecond Molecular Dynamics Simulations of Mg2+- and K+- Bound E1 Intermediate States of the Calcium Pump LM Espinoza-Fonseca, JM Autry, DD Thomas PLoS One 9 (4), e95979, 2014 | 42 | 2014 |
Atomic-level mechanisms for phospholamban regulation of the calcium pump LM Espinoza-Fonseca, JM Autry, GL Ramírez-Salinas, DD Thomas Biophysical journal 108 (7), 1697-1708, 2015 | 40 | 2015 |
Sarcolipin and phospholamban inhibit the calcium pump by populating a similar metal ion-free intermediate state LM Espinoza-Fonseca, JM Autry, DD Thomas Biochemical and biophysical research communications 463 (1-2), 37-41, 2015 | 39 | 2015 |
Aromatic residues link binding and function of intrinsically disordered proteins LM Espinoza-Fonseca Molecular BioSystems 8 (1), 237-246, 2012 | 39 | 2012 |
Nothing regular about the regulins: Distinct functional properties of SERCA transmembrane peptide regulatory subunits N Rathod, JJ Bak, JO Primeau, MLE Fisher, LM Espinoza-Fonseca, ... International Journal of Molecular Sciences 22 (16), 8891, 2021 | 35 | 2021 |
Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA MLE Fisher, E Bovo, R Aguayo-Ortiz, EE Cho, MP Pribadi, MP Dalton, ... Elife 10, e65545, 2021 | 35 | 2021 |