Integrin inactivators: balancing cellular functions in vitro and in vivo D Bouvard, J Pouwels, N De Franceschi, J Ivaska Nature reviews Molecular cell biology 14 (7), 430-442, 2013 | 279 | 2013 |
SHARPIN is an endogenous inhibitor of β1-integrin activation JK Rantala, J Pouwels, T Pellinen, S Veltel, P Laasola, E Mattila, ... Nature cell biology 13 (11), 1315-1324, 2011 | 240 | 2011 |
SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras J Lilja, T Zacharchenko, M Georgiadou, G Jacquemet, ND Franceschi, ... Nature cell biology 19 (4), 292-305, 2017 | 136 | 2017 |
Comparative structural analysis and substrate specificity engineering of the hyperthermostable β-glucosidase CelB from Pyrococcus furiosus T Kaper, JHG Lebbink, J Pouwels, J Kopp, GE Schulz, J van der Oost, ... Biochemistry 39 (17), 4963-4970, 2000 | 95 | 2000 |
Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2 N De Franceschi, A Arjonen, N Elkhatib, K Denessiouk, AG Wrobel, ... Nature structural & molecular biology 23 (2), 172-179, 2016 | 79 | 2016 |
Formin-like 2 promotes β1-integrin trafficking and invasive motility downstream of PKCα Y Wang, A Arjonen, J Pouwels, H Ta, P Pausch, G Bange, U Engel, X Pan, ... Developmental cell 34 (4), 475-483, 2015 | 74 | 2015 |
The cytoskeleton and the secretory pathway are not involved in targeting the cowpea mosaic virus movement protein to the cell periphery J Pouwels, GNM Van Der Krogt, J Van Lent, T Bisseling, J Wellink Virology 297 (1), 48-56, 2002 | 71 | 2002 |
Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1 J Pouwels, AM Kukkonen, W Lan, JR Daum, GJ Gorbsky, PT Stukenberg, ... Cell cycle 6 (13), 1579-1585, 2007 | 62 | 2007 |
SHARPIN regulates uropod detachment in migrating lymphocytes J Pouwels, N De Franceschi, P Rantakari, K Auvinen, M Karikoski, ... Cell reports 5 (3), 619-628, 2013 | 61 | 2013 |
Negative regulators of integrin activity J Pouwels, J Nevo, T Pellinen, J Ylänne, J Ivaska Journal of cell science 125 (14), 3271-3280, 2012 | 59 | 2012 |
Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint AL Salmela, J Pouwels, A Varis, AM Kukkonen, P Toivonen, PK Halonen, ... Carcinogenesis 30 (6), 1032-1040, 2009 | 55 | 2009 |
Studies on the origin and structure of tubules made by the movement protein of Cowpea mosaic virus J Pouwels, T Van Der Velden, J Willemse, JW Borst, J Van Lent, ... Journal of general virology 85 (12), 3787-3796, 2004 | 46 | 2004 |
Loss of p38γ MAPK induces pleiotropic mitotic defects and massive cell death A Kukkonen-Macchi, O Sicora, K Kaczynska, C Oetken-Lindholm, ... Journal of cell science 124 (2), 216-227, 2011 | 41 | 2011 |
Cowpea mosaic virus: effects on host cell processes J Pouwels, JE Carette, J Van Lent, J Wellink Molecular plant pathology 3 (6), 411-418, 2002 | 41 | 2002 |
Activity and stability of hyperthermophilic enzymes: a comparative study on two archaeal β-glycosidases J Pouwels, M Moracci, B Cobucci-Ponzano, G Perugino, J van der Oost, ... Extremophiles 4, 157-164, 2000 | 38 | 2000 |
Identification of distinct steps during tubule formation by the movement protein of Cowpea mosaic virus J Pouwels, N Kornet, N van Bers, T Guighelaar, J van Lent, T Bisseling, ... Journal of general virology 84 (12), 3485-3494, 2003 | 36 | 2003 |
Compressive stress-mediated p38 activation required for ERα+ phenotype in breast cancer PM Munne, L Martikainen, I Räty, K Bertula, Nonappa, J Ruuska, ... Nature communications 12 (1), 6967, 2021 | 32 | 2021 |
Perturbation of Incenp function impedes anaphase chromatid movements and chromosomal passenger protein flux at centromeres LJ Ahonen, AM Kukkonen, J Pouwels, MA Bolton, CD Jingle, ... Chromosoma 118, 71-84, 2009 | 31 | 2009 |
Mutually exclusive roles of SHARPIN in integrin inactivation and NF-κB signaling N De Franceschi, E Peuhu, M Parsons, S Rissanen, I Vattulainen, ... PloS one 10 (11), e0143423, 2015 | 30 | 2015 |
The flavonoid eupatorin inactivates the mitotic checkpoint leading to polyploidy and apoptosis AL Salmela, J Pouwels, A Kukkonen-Macchi, S Waris, P Toivonen, ... Experimental Cell Research 318 (5), 578-592, 2012 | 30 | 2012 |