| Sestrin2 is a leucine sensor for the mTORC1 pathway RL Wolfson, L Chantranupong, RA Saxton, K Shen, SM Scaria, JR Cantor, ... Science 351 (6268), 43-48, 2016 | 1184 | 2016 |
| Structural and functional analysis of the D614G SARS-CoV-2 spike protein variant L Yurkovetskiy, X Wang, KE Pascal, C Tomkins-Tinch, TP Nyalile, Y Wang, ... Cell 183 (3), 739-751. e8, 2020 | 1048 | 2020 |
| Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1 S Wang, ZY Tsun, RL Wolfson, K Shen, GA Wyant, ME Plovanich, ... Science 347 (6218), 188-194, 2015 | 815 | 2015 |
| The CASTOR proteins are arginine sensors for the mTORC1 pathway L Chantranupong, SM Scaria, RA Saxton, MP Gygi, K Shen, GA Wyant, ... Cell 165 (1), 153-164, 2016 | 770 | 2016 |
| Signal recognition particle: an essential protein-targeting machine D Akopian, K Shen, X Zhang, S Shan Annual review of biochemistry 82 (1), 693-721, 2013 | 534 | 2013 |
| A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity BC Grabiner, V Nardi, K Birsoy, R Possemato, K Shen, S Sinha, A Jordan, ... Cancer discovery 4 (5), 554-563, 2014 | 475 | 2014 |
| What are the pKa values of C–H bonds in aromatic heterocyclic compounds in DMSO? K Shen, Y Fu, JN Li, L Liu, QX Guo Tetrahedron 63 (7), 1568-1576, 2007 | 447 | 2007 |
| KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1 RL Wolfson, L Chantranupong, GA Wyant, X Gu, JM Orozco, K Shen, ... Nature 543 (7645), 438-442, 2017 | 301 | 2017 |
| The crystal structure of the signal recognition particle in complex with its receptor SF Ataide, N Schmitz, K Shen, A Ke, S Shan, JA Doudna, N Ban Science 331 (6019), 881-886, 2011 | 174 | 2011 |
| Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes K Shen, RK Huang, EJ Brignole, KJ Condon, ML Valenstein, ... Nature 556 (7699), 64-69, 2018 | 165 | 2018 |
| RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway JM Heo, A Ordureau, S Swarup, JA Paulo, K Shen, DM Sabatini, ... Science advances 4 (11), eaav0443, 2018 | 159 | 2018 |
| Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms K Shen, DM Sabatini Proceedings of the National Academy of Sciences 115 (38), 9545-9550, 2018 | 146 | 2018 |
| Cryo-EM structure of the human FLCN-FNIP2-Rag-ragulator complex K Shen, KB Rogala, HT Chou, RK Huang, Z Yu, DM Sabatini Cell 179 (6), 1319-1329. e8, 2019 | 113 | 2019 |
| Intersubunit crosstalk in the Rag GTPase heterodimer enables mTORC1 to respond rapidly to amino acid availability K Shen, A Choe, DM Sabatini Molecular cell 68 (3), 552-565. e8, 2017 | 94 | 2017 |
| Activated GTPase movement on an RNA scaffold drives co-translational protein targeting K Shen, S Arslan, D Akopian, T Ha, S Shan Nature 492 (7428), 271-275, 2012 | 89 | 2012 |
| ATP-independent reversal of a membrane protein aggregate by a chloroplast SRP subunit P Jaru-Ampornpan, K Shen, VQ Lam, M Ali, S Doniach, TZ Jia, S Shan Nature structural & molecular biology 17 (6), 696-702, 2010 | 89 | 2010 |
| SARS-CoV-2 Spike protein variant D614G increases infectivity and retains sensitivity to antibodies that target the receptor binding domain L Yurkovetskiy, KE Pascal, C Tomkins-Tinch, T Nyalile, Y Wang, A Baum, ... BioRxiv, 2020.07. 04.187757, 2020 | 83 | 2020 |
| Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases K Shen, ML Valenstein, X Gu, DM Sabatini Journal of Biological Chemistry 294 (8), 2970-5944, 2019 | 63 | 2019 |
| SecYEG activates GTPases to drive the completion of cotranslational protein targeting D Akopian, K Dalal, K Shen, F Duong, S Shan Journal of Cell Biology 200 (4), 397-405, 2013 | 57 | 2013 |
| The structural basis of FtsY recruitment and GTPase activation by SRP RNA F Voigts-Hoffmann, N Schmitz, K Shen, S Shan, SF Ataide, N Ban Molecular cell 52 (5), 643-654, 2013 | 52 | 2013 |
