Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling V Janssens, J Goris Biochemical Journal 353 (3), 417-439, 2001 | 2324 | 2001 |
PP2A: the expected tumor suppressor V Janssens, J Goris, C Van Hoof Current opinion in genetics & development 15 (1), 34-41, 2005 | 552 | 2005 |
PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail) V Janssens, S Longin, J Goris Trends in biochemical sciences 33 (3), 113-121, 2008 | 482 | 2008 |
Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells MHA Schmitz, M Held, V Janssens, JRA Hutchins, O Hudecz, E Ivanova, ... Nature cell biology 12 (9), 886-893, 2010 | 377 | 2010 |
Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis I Pastushenko, F Mauri, Y Song, F de Cock, B Meeusen, B Swedlund, ... Nature 589 (7842), 448-455, 2021 | 286 | 2021 |
Selection of protein phosphatase 2A regulatory subunits is mediated by the C terminus of the catalytic Subunit S Longin, K Zwaenepoel, JV Louis, S Dilworth, J Goris, V Janssens Journal of Biological Chemistry 282 (37), 26971-26980, 2007 | 264 | 2007 |
Combination of hypoglycemia and metformin impairs tumor metabolic plasticity and growth by modulating the PP2A-GSK3β-MCL-1 axis M Elgendy, M Ciro, A Hosseini, J Weiszmann, L Mazzarella, E Ferrari, ... Cancer cell 35 (5), 798-815. e5, 2019 | 259 | 2019 |
The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity W Sents, E Ivanova, C Lambrecht, D Haesen, V Janssens The FEBS journal 280 (2), 644-661, 2013 | 247 | 2013 |
Purification of Porcine Brain Protein Phosphatase 2A Leucine Carboxyl Methyltransferase and Cloning of the Human Homologue, I De Baere, R Derua, V Janssens, C Van Hoof, E Waelkens, W Merlevede, ... Biochemistry 38 (50), 16539-16547, 1999 | 203 | 1999 |
Fructose-1, 6-bisphosphate couples glycolytic flux to activation of Ras K Peeters, F Van Leemputte, B Fischer, BM Bonini, H Quezada, ... Nature communications 8 (1), 922, 2017 | 192 | 2017 |
The protein phosphatase 2A phosphatase activator is a novel peptidyl-prolyl cis/trans-isomerase J Jordens, V Janssens, S Longin, I Stevens, E Martens, G Bultynck, ... Journal of Biological Chemistry 281 (10), 6349-6357, 2006 | 152 | 2006 |
PP2AT61ɛ is an inhibitor of MAP4K3 in nutrient signaling to mTOR L Yan, V Mieulet, D Burgess, GM Findlay, K Sully, J Procter, J Goris, ... Molecular cell 37 (5), 633-642, 2010 | 146 | 2010 |
An inactive protein phosphatase 2A population is associated with methylesterase and can be re-activated by the phosphotyrosyl phosphatase activator S Longin, J Jordens, E Martens, I Stevens, V Janssens, E Rondelez, ... Biochemical Journal 380 (1), 111-119, 2004 | 146 | 2004 |
Structure, regulation, and pharmacological modulation of PP2A phosphatases C Lambrecht, D Haesen, W Sents, E Ivanova, V Janssens Phosphatase Modulators, 283-305, 2013 | 139 | 2013 |
PP1 and PP2A phosphatases–cooperating partners in modulating retinoblastoma protein activation V Kolupaeva, V Janssens The FEBS journal 280 (2), 627-643, 2013 | 131 | 2013 |
Mice lacking phosphatase PP2A subunit PR61/B’δ (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3β JV Louis, E Martens, P Borghgraef, C Lambrecht, W Sents, S Longin, ... Proceedings of the National Academy of Sciences 108 (17), 6957-6962, 2011 | 126 | 2011 |
Physiologic functions of PP2A: Lessons from genetically modified mice S Reynhout, V Janssens Biochimica Et Biophysica Acta (BBA)-Molecular Cell Research 1866 (1), 31-50, 2019 | 125 | 2019 |
B56δ-related protein phosphatase 2A dysfunction identified in patients with intellectual disability G Houge, D Haesen, LELM Vissers, S Mehta, MJ Parker, M Wright, J Vogt, ... The Journal of clinical investigation 125 (8), 3051-3062, 2015 | 123 | 2015 |
Identification and functional analysis of two Ca2+-binding EF-hand motifs in the B “/PR72 subunit of protein phosphatase 2A V Janssens, J Jordens, I Stevens, C Van Hoof, E Martens, H De Smedt, ... Journal of Biological Chemistry 278 (12), 10697-10706, 2003 | 122 | 2003 |
The B″/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A JH Ahn, JY Sung, T McAvoy, A Nishi, V Janssens, J Goris, P Greengard, ... Proceedings of the National Academy of Sciences 104 (23), 9876-9881, 2007 | 116 | 2007 |