Integrative analysis of 111 reference human epigenomes A Kundaje, W Meuleman, J Ernst, M Bilenky, A Yen, A Heravi-Moussavi, ... Nature 518 (7539), 317-330, 2015 | 6178 | 2015 |
Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET T Matsui, D Leung, H Miyashita, IA Maksakova, H Miyachi, H Kimura, ... Nature 464 (7290), 927-931, 2010 | 816 | 2010 |
Epigenomic analysis of multilineage differentiation of human embryonic stem cells W Xie, MD Schultz, R Lister, Z Hou, N Rajagopal, P Ray, JW Whitaker, ... Cell 153 (5), 1134-1148, 2013 | 786 | 2013 |
Human body epigenome maps reveal noncanonical DNA methylation variation MD Schultz, Y He, JW Whitaker, M Hariharan, EA Mukamel, D Leung, ... Nature 523 (7559), 212-216, 2015 | 663 | 2015 |
The International Human Epigenome Consortium: a blueprint for scientific collaboration and discovery HG Stunnenberg, S Abrignani, D Adams, M de Almeida, L Altucci, V Amin, ... Cell 167 (5), 1145-1149, 2016 | 531 | 2016 |
DNA methylation and SETDB1/H3K9me3 regulate predominantly distinct sets of genes, retroelements, and chimeric transcripts in mESCs MM Karimi, P Goyal, IA Maksakova, M Bilenky, D Leung, JX Tang, ... Cell stem cell 8 (6), 676-687, 2011 | 524 | 2011 |
The 3D genome in transcriptional regulation and pluripotency DU Gorkin, D Leung, B Ren Cell stem cell 14 (6), 762-775, 2014 | 447 | 2014 |
DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity KB Dong, IA Maksakova, F Mohn, D Leung, R Appanah, S Lee, HW Yang, ... The EMBO journal 27 (20), 2691-2701, 2008 | 284 | 2008 |
Integrative analysis of haplotype-resolved epigenomes across human tissues D Leung, I Jung, N Rajagopal, A Schmitt, S Selvaraj, AY Lee, CA Yen, ... Nature 518 (7539), 350-354, 2015 | 263 | 2015 |
Silencing of endogenous retroviruses: when and why do histone marks predominate? DC Leung, MC Lorincz Trends in biochemical sciences 37 (4), 127-133, 2012 | 164 | 2012 |
Lysine methyltransferase G9a is required for de novo DNA methylation and the establishment, but not the maintenance, of proviral silencing DC Leung, KB Dong, IA Maksakova, P Goyal, R Appanah, S Lee, ... Proceedings of the National Academy of Sciences 108 (14), 5718-5723, 2011 | 142 | 2011 |
Isoform switch of TET1 regulates DNA demethylation and mouse development W Zhang, W Xia, Q Wang, AJ Towers, J Chen, R Gao, Y Zhang, C Yen, ... Molecular cell 64 (6), 1062-1073, 2016 | 123 | 2016 |
Replication timing maintains the global epigenetic state in human cells KN Klein, PA Zhao, X Lyu, T Sasaki, DA Bartlett, AM Singh, I Tasan, ... Science 372 (6540), 371-378, 2021 | 118 | 2021 |
Regulation of DNA methylation turnover at LTR retrotransposons and imprinted loci by the histone methyltransferase Setdb1 D Leung, T Du, U Wagner, W Xie, AY Lee, P Goyal, Y Li, KE Szulwach, ... Proceedings of the National Academy of Sciences 111 (18), 6690-6695, 2014 | 107 | 2014 |
Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression A Baradaran-Heravi, KS Cho, B Tolhuis, M Sanyal, O Morozova, ... Human molecular genetics 21 (11), 2572-2587, 2012 | 75 | 2012 |
Impact of flanking chromosomal sequences on localization and silencing by the human non-coding RNA XIST AD Kelsey, C Yang, D Leung, J Minks, T Dixon-McDougall, SEL Baldry, ... Genome biology 16, 1-16, 2015 | 51 | 2015 |
G9a plays distinct roles in maintaining DNA methylation, retrotransposon silencing, and chromatin looping Q Jiang, JYJ Ang, AY Lee, Q Cao, KY Li, KY Yip, DCY Leung Cell reports 33 (4), 2020 | 45 | 2020 |
Humanizing the yeast origin recognition complex CSK Lee, MF Cheung, J Li, Y Zhao, WH Lam, V Ho, R Rohs, Y Zhai, ... Nature communications 12 (1), 33, 2021 | 36 | 2021 |
DNA repair inhibition leads to active export of repetitive sequences to the cytoplasm triggering an inflammatory response X Song, JTM Aw, F Ma, MF Cheung, D Leung, K Herrup Journal of Neuroscience 41 (45), 9286-9307, 2021 | 19 | 2021 |
A unified framework for integrative study of heterogeneous gene regulatory mechanisms Q Cao, Z Zhang, AX Fu, Q Wu, TL Lee, E Lo, ASL Cheng, C Cheng, ... Nature Machine Intelligence 2 (8), 447-456, 2020 | 12 | 2020 |