| Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities M Bäck, A Yurdagul Jr, I Tabas, K Öörni, PT Kovanen Nature Reviews Cardiology 16 (7), 389-406, 2019 | 1175 | 2019 |
| Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation K Rajamäki, J Lappalainen, K Öörni, E Välimäki, S Matikainen, ... PloS one 5 (7), e11765, 2010 | 1105 | 2010 |
| Extracellular acidosis is a novel danger signal alerting innate immunity via the NLRP3 inflammasome K Rajamäki, T Nordström, K Nurmi, KEO Åkerman, PT Kovanen, K Öörni, ... Journal of Biological Chemistry 288 (19), 13410-13419, 2013 | 372 | 2013 |
| Aggregation, fusion, and vesicle formation of modified low density lipoprotein particles: molecular mechanisms and effects on matrix interactions K Öörni, MO Pentikäinen, M Ala-Korpela, PT Kovanen Journal of lipid research 41 (11), 1703-1714, 2000 | 335 | 2000 |
| Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway K Niemi, L Teirilä, J Lappalainen, K Rajamäki, MH Baumann, K Öörni, ... The Journal of Immunology 186 (11), 6119-6128, 2011 | 328 | 2011 |
| Modified LDL–trigger of atherosclerosis and inflammation in the arterial intima MO Pentikäinen, K Öörni, M Ala‐Korpela, PT Kovanen Journal of internal medicine 247 (3), 359-370, 2000 | 290 | 2000 |
| Angptl3 deficiency is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids MR Robciuc, M Maranghi, A Lahikainen, D Rader, A Bensadoun, K Öörni, ... Arteriosclerosis, thrombosis, and vascular biology 33 (7), 1706-1713, 2013 | 191 | 2013 |
| Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths M Ruuth, SD Nguyen, T Vihervaara, M Hilvo, TD Laajala, PK Kondadi, ... European heart journal 39 (27), 2562-2573, 2018 | 167 | 2018 |
| Sphingomyelinase induces aggregation and fusion, but phospholipase A2 only aggregation, of low density lipoprotein (LDL) particles: two distinct mechanisms leading to increased … K Öörni, JK Hakala, A Annila, M Ala-Korpela, PT Kovanen Journal of Biological Chemistry 273 (44), 29127-29134, 1998 | 154 | 1998 |
| Lipolysis of LDL by Human Secretory Phospholipase A2 Induces Particle Fusion and Enhances the Retention of LDL to Human Aortic Proteoglycans JK Hakala, K Öörni, MO Pentikäinen, E Hurt-Camejo, PT Kovanen Arteriosclerosis, Thrombosis, and Vascular Biology 21 (6), 1053-1058, 2001 | 150 | 2001 |
| Lipoprotein lipase in the arterial wall: linking LDL to the arterial extracellular matrix and much more MO Pentikäinen, R Oksjoki, K Öörni, PT Kovanen Arteriosclerosis, thrombosis, and vascular biology 22 (2), 211-217, 2002 | 141 | 2002 |
| Increased expression of elastolytic cathepsins S, K, and V and their inhibitor cystatin C in stenotic aortic valves S Helske, S Syväranta, KA Lindstedt, J Lappalainen, K Öörni, ... Arteriosclerosis, thrombosis, and vascular biology 26 (8), 1791-1798, 2006 | 138 | 2006 |
| Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro K Öörni, M Sneck, D Brömme, MO Pentikäinen, KA Lindstedt, ... Journal of Biological Chemistry 279 (33), 34776-34784, 2004 | 136 | 2004 |
| Oxidation of low density lipoprotein particles decreases their ability to bind to human aortic proteoglycans: dependence on oxidative modification of the lysine residues K Öörni, MO Pentikäinen, A Annila, PT Kovanen Journal of Biological Chemistry 272 (34), 21303-21311, 1997 | 110 | 1997 |
| Sphingomyelinase induces aggregation and fusion of small very low–density lipoprotein and intermediate-density lipoprotein particles and increases their retention to human … K Öörni, P Posio, M Ala-Korpela, M Jauhiainen, PT Kovanen Arteriosclerosis, thrombosis, and vascular biology 25 (8), 1678-1683, 2005 | 109 | 2005 |
| Cathepsins F and S block HDL3-induced cholesterol efflux from macrophage foam cells L Lindstedt, M Lee, K Öörni, D Brömme, PT Kovanen Biochemical and biophysical research communications 312 (4), 1019-1024, 2003 | 99 | 2003 |
| The proteoglycan decorin links low density lipoproteins with collagen type I MO Pentikäinen, K Öörni, R Lassila, PT Kovanen Journal of Biological Chemistry 272 (12), 7633-7638, 1997 | 99 | 1997 |
| Acidification of the intimal fluid: the perfect storm for atherogenesis K Öörni, K Rajamäki, SD Nguyen, K Lähdesmäki, R Plihtari, ... Journal of lipid research 56 (2), 203-214, 2015 | 90 | 2015 |
| Three-dimensional cryoEM reconstruction of native LDL particles to 16Å resolution at physiological body temperature V Kumar, SJ Butcher, K Öörni, P Engelhardt, J Heikkonen, K Kaski, ... PloS one 6 (5), e18841, 2011 | 89 | 2011 |
| PCSK9 inhibition alters the lipidome of plasma and lipoprotein fractions M Hilvo, H Simolin, J Metso, M Ruuth, K Öörni, M Jauhiainen, ... Atherosclerosis 269, 159-165, 2018 | 75 | 2018 |
