Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor S Mary, M Damian, M Louet, N Floquet, JA Fehrentz, J Marie, J Martinez, ... Proceedings of the National Academy of Sciences 109 (21), 8304-8309, 2012 | 118 | 2012 |
Coarse-grained simulations of the HIV-1 matrix protein anchoring: revisiting its assembly on membrane domains L Charlier, M Louet, L Chaloin, P Fuchs, J Martinez, D Muriaux, C Favard, ... Biophysical journal 106 (3), 577-585, 2014 | 80 | 2014 |
Pharmacogenomics of the cytochrome P450 2C family: impacts of amino acid variations on drug metabolism A Isvoran, M Louet, DL Vladoiu, D Craciun, MA Loriot, BO Villoutreix, ... Drug Discovery Today 22 (2), 366-376, 2017 | 79 | 2017 |
GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation M Damian, V Pons, P Renault, C M’kadmi, B Delort, L Hartmann, AI Kaya, ... Proceedings of the National Academy of Sciences 115 (17), 4501-4506, 2018 | 65 | 2018 |
Structure and dynamics of G protein-coupled receptor–bound ghrelin reveal the critical role of the octanoyl chain G Ferré, M Louet, O Saurel, B Delort, G Czaplicki, C M’kadmi, M Damian, ... Proceedings of the National Academy of Sciences 116 (35), 17525-17530, 2019 | 59 | 2019 |
Insights into molecular mechanisms of drug metabolism dysfunction of human CYP2C9* 30 M Louet, CM Labbe, C Fagnen, CM Aono, P Homem-de-Mello, ... PLoS One 13 (5), e0197249, 2018 | 37 | 2018 |
A concerted mechanism for opening the GDP binding pocket and release of the nucleotide in hetero-trimeric G-proteins M Louet, D Perahia, J Martinez, N Floquet Journal of molecular biology 411 (1), 298-312, 2011 | 36 | 2011 |
Allosteric modulation of ghrelin receptor signaling by lipids M Damian, M Louet, AAS Gomes, C M’kadmi, S Denoyelle, S Cantel, ... Nature communications 12 (1), 3938, 2021 | 33 | 2021 |
Cryo–electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex J Bous, H Orcel, N Floquet, C Leyrat, J Lai-Kee-Him, G Gaibelet, ... Science Advances 7 (21), eabg5628, 2021 | 33 | 2021 |
GDP release preferentially occurs on the phosphate side in heterotrimeric G-proteins M Louet, J Martinez, N Floquet PLoS computational biology 8 (7), e1002595, 2012 | 26 | 2012 |
Dynamic allostery of the catabolite activator protein revealed by interatomic forces M Louet, C Seifert, U Hensen, F Gräter PLoS computational biology 11 (8), e1004358, 2015 | 22 | 2015 |
Molecular Dynamics Simulations of the Allosteric Modulation of the Adenosine A2a Receptor by a Mini-G Protein P Renault, M Louet, J Marie, G Labesse, N Floquet Scientific reports 9 (1), 5495, 2019 | 20 | 2019 |
In silico model of the human ClC-Kb chloride channel: pore mapping, biostructural pathology and drug screening M Louet, S Bitam, N Bakouh, Y Bignon, G Planelles, D Lagorce, ... Scientific reports 7 (1), 7249, 2017 | 14 | 2017 |
Conformational restriction of G-proteins Coupled Receptors (GPCRs) upon complexation to G-proteins: A putative activation mode of GPCRs? M Louet, E Karakas, A Perret, D Perahia, J Martinez, N Floquet FEBS letters 587 (16), 2656-2661, 2013 | 12 | 2013 |
Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor M Louet, M Casiraghi, M Damian, MGS Costa, P Renault, AAS Gomes, ... Elife 10, e63201, 2021 | 6 | 2021 |
Dissociation of Membrane-Anchored Heterotrimeric G-Protein Induced by Gα Subunit Binding to GTP M Louet, L Charlier, J Martinez, N Floquet Journal of chemical information and modeling 52 (11), 3022-3027, 2012 | 4 | 2012 |
Sodium is a negative allosteric regulator of the ghrelin receptor G Ferré, AAS Gomes, M Louet, M Damian, PM Bisch, O Saurel, N Floquet, ... Cell Reports 42 (4), 2023 | 3 | 2023 |
MDexciteR: enhanced sampling molecular dynamics by excited normal modes or principal components obtained from experiments MGS Costa, PR Batista, A Gomes, LS Bastos, M Louet, N Floquet, ... Journal of Chemical Theory and Computation 19 (2), 412-425, 2023 | 3 | 2023 |
Discovering NDM-1 inhibitors using molecular substructure embeddings representations T Papastergiou, J Azé, S Bringay, M Louet, P Poncelet, ... Journal of Integrative Bioinformatics 20 (2), 20220050, 2023 | 1 | 2023 |
Identification of First-in-class inhibitors of Kallikrein-Related peptidase 6 that promote oligodendrocyte differentiation S Aït Amiri, C Deboux, F Soualmia, N Chaaya, M Louet, E Duplus, ... Journal of Medicinal Chemistry 64 (9), 5667-5688, 2021 | 1 | 2021 |