关注
Aaron Smith
Aaron Smith
在 astrazeneca.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists
W Toy, H Weir, P Razavi, M Lawson, AU Goeppert, AM Mazzola, A Smith, ...
Cancer discovery 7 (3), 277-287, 2017
3452017
The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models
ST Durant, L Zheng, Y Wang, K Chen, L Zhang, T Zhang, Z Yang, ...
Science advances 4 (6), eaat1719, 2018
2442018
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity
JHL Fok, A Ramos-Montoya, M Vazquez-Chantada, PWG Wijnhoven, ...
Nature communications 10 (1), 5065, 2019
2402019
Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo
S Ashton, YH Song, J Nolan, E Cadogan, J Murray, R Odedra, J Foster, ...
Science translational medicine 8 (325), 325ra17-325ra17, 2016
2182016
Preclinical comparison of the blood–brain barrier permeability of osimertinib with other EGFR TKIs
N Colclough, K Chen, P Johnström, N Strittmatter, Y Yan, GL Wrigley, ...
Clinical Cancer Research 27 (1), 189-201, 2021
1342021
Pharmacology of the ATM inhibitor AZD0156: potentiation of irradiation and olaparib responses preclinically
LC Riches, AG Trinidad, G Hughes, GN Jones, AM Hughes, ...
Molecular cancer therapeutics 19 (1), 13-25, 2020
1222020
The MET inhibitor AZD6094 (Savolitinib, HMPL-504) induces regression in papillary renal cell carcinoma patient–derived xenograft models
AG Schuller, ER Barry, RDO Jones, RE Henry, MM Frigault, G Beran, ...
Clinical Cancer Research 21 (12), 2811-2819, 2015
742015
Orally bioavailable and blood–brain barrier-penetrating ATM inhibitor (AZ32) radiosensitizes intracranial gliomas in mice
J Karlin, J Allen, SF Ahmad, G Hughes, V Sheridan, R Odedra, ...
Molecular cancer therapeutics 17 (8), 1637-1647, 2018
582018
Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT …
JG Kettle, R Anjum, E Barry, D Bhavsar, C Brown, S Boyd, A Campbell, ...
Journal of Medicinal Chemistry 61 (19), 8797-8810, 2018
532018
Preclinical characterization of AZD5305, a next-generation, highly selective PARP1 inhibitor and trapper
G Illuzzi, AD Staniszewska, SJ Gill, A Pike, L McWilliams, SE Critchlow, ...
Clinical Cancer Research 28 (21), 4724-4736, 2022
502022
A rapid computational filter for predicting the rate of human renal clearance
SW Paine, P Barton, J Bird, R Denton, K Menochet, A Smith, ...
Journal of Molecular Graphics and Modelling 29 (4), 529-537, 2010
452010
Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers
RM England, JI Hare, J Barnes, J Wilson, A Smith, N Strittmatter, ...
Journal of Controlled Release 247, 73-85, 2017
422017
ALT neuroblastoma chemoresistance due to telomere dysfunction–induced ATM activation is reversible with ATM inhibitor AZD0156
B Koneru, A Farooqi, TH Nguyen, WH Chen, A Hindle, C Eslinger, ...
Science translational medicine 13 (607), eabd5750, 2021
402021
Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response
T Petreus, E Cadogan, G Hughes, A Smith, V Pilla Reddy, A Lau, ...
Communications Biology 4 (1), 1001, 2021
342021
Selumetinib-based therapy in uveal melanoma patient-derived xenografts
D Decaudin, R El Botty, B Diallo, G Massonnet, J Fleury, A Naguez, ...
Oncotarget 9 (31), 21674, 2018
292018
The novel ATM inhibitor (AZ31) enhances antitumor activity in patient derived xenografts that are resistant to irinotecan monotherapy
J Greene, A Nguyen, SM Bagby, GN Jones, WM Tai, KS Quackenbush, ...
Oncotarget 8 (67), 110904, 2017
222017
Evaluation of laser diode thermal desorption (LDTD) coupled with tandem mass spectrometry (MS/MS) for support of in vitro drug discovery assays: Increasing scope, robustness …
I Beattie, A Smith, DJ Weston, P White, S Szwandt, L Sealey
Journal of pharmaceutical and biomedical analysis 59, 18-28, 2012
222012
Method to visualize the intratumor distribution and impact of gemcitabine in pancreatic ductal adenocarcinoma by multimodal imaging
N Strittmatter, FM Richards, AM Race, S Ling, D Sutton, A Nilsson, ...
Analytical Chemistry 94 (3), 1795-1803, 2022
212022
AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor …
V Flemington, EJ Davies, D Robinson, LC Sandin, O Delpuech, P Zhang, ...
Molecular cancer therapeutics 20 (2), 238-249, 2021
162021
Quantifying drug‐induced bone marrow toxicity using a novel haematopoiesis systems pharmacology model
C Fornari, L Oplustil O'Connor, C Pin, A Smith, JWT Yates, SYA Cheung, ...
CPT: Pharmacometrics & Systems Pharmacology 8 (11), 858-868, 2019
152019
系统目前无法执行此操作,请稍后再试。
文章 1–20