Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells JLO Pohjoismäki, S Wanrooij, AK Hyvärinen, S Goffart, IJ Holt, ... Nucleic acids research 34 (20), 5815-5828, 2006 | 186 | 2006 |
Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes S Wanrooij, S Goffart, JLO Pohjoismäki, T Yasukawa, JN Spelbrink Nucleic acids research 35 (10), 3238-3251, 2007 | 156 | 2007 |
Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid JLO Pohjoismäki, JB Holmes, SR Wood, MY Yang, T Yasukawa, A Reyes, ... Journal of molecular biology 397 (5), 1144-1155, 2010 | 151 | 2010 |
The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA AK Hyvärinen, JLO Pohjoismäki, A Reyes, S Wanrooij, T Yasukawa, ... Nucleic acids research 35 (19), 6458-6474, 2007 | 150 | 2007 |
Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks JLO Pohjoismäki, S Goffart, H Tyynismaa, S Willcox, T Ide, D Kang, ... Journal of biological chemistry 284 (32), 21446-21457, 2009 | 144 | 2009 |
Indoors forensic entomology: colonization of human remains in closed environments by specific species of sarcosaprophagous flies JLO Pohjoismäki, PJ Karhunen, S Goebeler, P Saukko, IE Sääksjärvi Forensic Science International 199 (1-3), 38-42, 2010 | 134 | 2010 |
The role of mitochondria in cardiac development and protection JL Pohjoismäki, S Goffart Free Radical Biology and Medicine 106, 345-354, 2017 | 119 | 2017 |
Tissue specific differences in mitochondrial DNA maintenance and expression E Herbers, NJ Kekäläinen, A Hangas, JL Pohjoismäki, S Goffart Mitochondrion 44, 85-92, 2019 | 117 | 2019 |
Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2 A Hangas, K Aasumets, NJ Kekäläinen, M Paloheinä, JL Pohjoismäki, ... Nucleic acids research 46 (18), 9625-9636, 2018 | 102 | 2018 |
Establishing a community‐wide DNA barcode library as a new tool for arctic research H Wirta, G Várkonyi, C Rasmussen, R Kaartinen, NM Schmidt, ... Molecular ecology resources 16 (3), 809-822, 2016 | 97 | 2016 |
Of circles, forks and humanity: Topological organisation and replication of mammalian mitochondrial DNA JLO Pohjoismäki, S Goffart Bioessays 33 (4), 290-299, 2011 | 94 | 2011 |
ATAD3 controls mitochondrial cristae structure in mouse muscle, influencing mtDNA replication and cholesterol levels S Peralta, S Goffart, SL Williams, F Diaz, S Garcia, N Nissanka, ... Journal of cell science 131 (13), jcs217075, 2018 | 91 | 2018 |
PrimPol is required for replication reinitiation after mtDNA damage R Torregrosa-Muñumer, JME Forslund, S Goffart, A Pfeiffer, G Stojkovič, ... Proceedings of the National Academy of Sciences 114 (43), 11398-11403, 2017 | 88 | 2017 |
Oxidative stress during mitochondrial biogenesis compromises mtDNA integrity in growing hearts and induces a global DNA repair response JLO Pohjoismäki, T Boettger, Z Liu, S Goffart, M Szibor, T Braun Nucleic acids research 40 (14), 6595-6607, 2012 | 68 | 2012 |
Overexpression of MTERFD1 or MTERFD3 impairs the completion of mitochondrial DNA replication AK Hyvärinen, JLO Pohjoismäki, IJ Holt, HT Jacobs Molecular biology reports 38, 1321-1328, 2011 | 63 | 2011 |
Developmental and pathological changes in the human cardiac muscle mitochondrial DNA organization, replication and copy number JLO Pohjoismäki, S Goffart, RW Taylor, DM Turnbull, A Suomalainen, ... PloS one 5 (5), e10426, 2010 | 63 | 2010 |
Low doses of ultraviolet radiation and oxidative damage induce dramatic accumulation of mitochondrial DNA replication intermediates, fork regression, and replication initiation … R Torregrosa-Muñumer, S Goffart, JA Haikonen, JLO Pohjoismäki Molecular biology of the cell 26 (23), 4197-4208, 2015 | 55 | 2015 |
A molecular‐based identification resource for the arthropods of Finland T Roslin, P Somervuo, M Pentinsaari, PDN Hebert, J Agda, P Ahlroth, ... Molecular Ecology Resources 22 (2), 803-822, 2022 | 47 | 2022 |
Overexpression of Twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species JLO Pohjoismäki, SL Williams, T Boettger, S Goffart, J Kim, ... Proceedings of the National Academy of Sciences 110 (48), 19408-19413, 2013 | 46 | 2013 |
Postnatal cardiomyocyte growth and mitochondrial reorganization cause multiple changes in the proteome of human cardiomyocytes JLO Pohjoismäki, M Krüger, N Al-Furoukh, A Lagerstedt, PJ Karhunen, ... Molecular bioSystems 9 (6), 1210-1219, 2013 | 46 | 2013 |