The alkyne moiety as a latent electrophile in irreversible covalent small molecule inhibitors of cathepsin K E Mons, IDC Jansen, J Loboda, BR van Doodewaerd, J Hermans, ... Journal of the American Chemical Society 141 (8), 3507-3514, 2019 | 95 | 2019 |
Organocatalytic enantioselective Pictet–Spengler reactions for the syntheses of 1-substituted 1, 2, 3, 4-tetrahydroisoquinolines E Mons, MJ Wanner, S Ingemann, JH van Maarseveen, H Hiemstra The Journal of Organic Chemistry 79 (16), 7380-7390, 2014 | 84 | 2014 |
A comprehensive guide for assessing covalent inhibition in enzymatic assays illustrated with kinetic simulations E Mons, S Roet, RQ Kim, MPC Mulder Current Protocols 2 (6), e419, 2022 | 46 | 2022 |
Exploring the versatility of the covalent thiol–alkyne reaction with substituted propargyl warheads: a deciding role for the cysteine protease E Mons, RQ Kim, BR van Doodewaerd, PA van Veelen, MPC Mulder, ... Journal of the American Chemical Society 143 (17), 6423-6433, 2021 | 45 | 2021 |
Profiling withanolide A for therapeutic targets in neurodegenerative diseases EA Crane, W Heydenreuter, KR Beck, P Strajhar, J Vomacka, M Smiesko, ... Bioorganic & medicinal chemistry 27 (12), 2508-2520, 2019 | 12 | 2019 |
Technologies for Direct Detection of Covalent Protein–Drug Adducts E Mons, RQ Kim, MPC Mulder Pharmaceuticals 16 (4), 547, 2023 | 7 | 2023 |
Cathepsin Inhibitors H Ovaa, MWE Mons, S van Boeckel WO2019112426A1, 2019 | 3 | 2019 |
Alkynes in covalent enzyme inhibitors: down the kinetic rabbit hole E Mons Leiden University, 2024 | | 2024 |