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Miroslav Kašpar
Miroslav Kašpar
IOCB
在 uochb.cas.cz 的电子邮件经过验证
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(E)-7-Ethylidene-lithocholic acid (7-ELCA) is a potent dual farnesoid X receptor (FXR) antagonist and GPBAR1 agonist inhibiting FXR-induced gene expression in hepatocytes and …
A Stefela, M Kaspar, M Drastik, T Kronenberger, S Micuda, M Dracinsky, ...
Frontiers in pharmacology 12, 713149, 2021
72021
Selectivity of Oxidizing Agents toward Axial and Equatorial Hydroxyl Groups
M Kaspar, E Kudova
The Journal of Organic Chemistry 87 (14), 9157-9170, 2022
62022
3β-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3α-epimer by hepatic metabolism
A Stefela, M Kaspar, M Drastik, O Holas, M Hroch, T Smutny, J Skoda, ...
The Journal of steroid biochemistry and molecular biology 202, 105702, 2020
62020
When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists
A Díaz‐Holguín, A Rashidian, D Pijnenburg, G Monteiro Ferreira, ...
ChemMedChem 18 (4), e202200556, 2023
12023
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