| Induction of apoptosis by the Bcl-2 homologue Bak T Chittenden, EA Harrington, R O'Connor, C Remington, RJ Lutz, GI Evan, ... Nature 374 (6524), 733-736, 1995 | 1046 | 1995 |
| Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling AM Moloney, RJ Griffin, S Timmons, R O’Connor, R Ravid, C O’Neill Neurobiology of aging 31 (2), 224-243, 2010 | 831 | 2010 |
| Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology RJ Griffin, A Moloney, M Kelliher, JA Johnston, R Ravid, P Dockery, ... Journal of neurochemistry 93 (1), 105-117, 2005 | 522 | 2005 |
| Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer SA Eccles, EO Aboagye, S Ali, AS Anderson, J Armes, F Berditchevski, ... Breast Cancer Research 15, 1-37, 2013 | 512 | 2013 |
| Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis R O’Connor, A Kauffmann-Zeh, Y Liu, S Lehar, GI Evan, R Baserga, ... Molecular and cellular biology, 1997 | 307 | 1997 |
| RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death PA Kiely, A Sant, R O'Connor Journal of Biological Chemistry 277 (25), 22581-22589, 2002 | 170 | 2002 |
| Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines T Torigoe, R O'Connor, D Santoli, JC Reed | 164 | 1992 |
| Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of … DA Buckley, A Cheng, PA Kiely, ML Tremblay, R O'Connor Molecular and cellular biology 22 (7), 1998-2010, 2002 | 155 | 2002 |
| PBK/TOPK promotes tumour cell proliferation through p38 MAPK activity and regulation of the DNA damage response V Ayllon, R O'connor Oncogene 26 (24), 3451-3461, 2007 | 154 | 2007 |
| The insulin-like growth factor-I–mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth S Floyd, C Favre, FM Lasorsa, M Leahy, G Trigiante, P Stroebel, A Marx, ... Molecular biology of the cell 18 (9), 3545-3555, 2007 | 135 | 2007 |
| Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and β1 integrin to promote cell migration PA Kiely, D O'Gorman, K Luong, D Ron, R O'Connor Molecular and cellular biology 26 (11), 4041-4051, 2006 | 130 | 2006 |
| A cell viability assay based on monitoring respiration by optical oxygen sensing TC O'Riordan, D Buckley, V Ogurtsov, R O'Connor, DB Papkovsky Analytical Biochemistry 278 (2), 221-227, 2000 | 130 | 2000 |
| Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase PA Kiely, GS Baillie, R Barrett, DA Buckley, DR Adams, MD Houslay, ... Journal of Biological Chemistry 284 (30), 20263-20274, 2009 | 124 | 2009 |
| Fluorescence-based cell viability screening assays using water-soluble oxygen probes J Hynes, S Floyd, AE Soini, R O'Connor, DB Papkovsky SLAS Discovery 8 (3), 264-272, 2003 | 121 | 2003 |
| Homing and progression patterns of childhood acute lymphoblastic leukemias in severe combined immunodeficiency mice A Cesano, R O'Connor, B Lange, J Finan, G Rovera, D Santoli | 115 | 1991 |
| Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level DP Macartney-Coxson, KA Hood, H Shi, T Ward, A Wiles, R O'Connor, ... BMC cancer 8, 1-11, 2008 | 109 | 2008 |
| Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis E Kerr, C Holohan, KM McLaughlin, J Majkut, S Dolan, K Redmond, ... Cell Death & Differentiation 19 (8), 1317-1327, 2012 | 107 | 2012 |
| Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses Anchorage-independent growth G Loughran, NC Healy, PA Kiely, M Huigsloot, NL Kedersha, R O'Connor Molecular biology of the cell 16 (4), 1811-1822, 2005 | 107 | 2005 |
| Regulation of IGF-I receptor signaling in tumor cells R O'Connor Hormone and Metabolic Research 35 (11/12), 771-777, 2003 | 105 | 2003 |
| RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at … PA Kiely, M Leahy, D O'Gorman, R O'Connor Journal of Biological Chemistry 280 (9), 7624-7633, 2005 | 103 | 2005 |
