Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores X Liu, Z Zhang, J Ruan, Y Pan, VG Magupalli, H Wu, J Lieberman Nature 535 (7610), 153-158, 2016 | 1975 | 2016 |
ABAD directly links Aß to mitochondrial toxicity in Alzheimer's disease JW Lustbader, M Cirilli, C Lin, HW Xu, K Takuma, N Wang, C Caspersen, ... Science 304 (5669), 448-452, 2004 | 1508 | 2004 |
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug H Wu, E Esteve, V Tremaroli, MT Khan, R Caesar, L Mannerås-Holm, ... Nature medicine 23 (7), 850-858, 2017 | 1171 | 2017 |
Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling SC Lin, YC Lo, H Wu Nature 465 (7300), 885-890, 2010 | 1136 | 2010 |
The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis J Li, T McQuade, AB Siemer, J Napetschnig, K Moriwaki, YS Hsiao, ... Cell 150 (2), 339-350, 2012 | 1082 | 2012 |
Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes A Lu, VG Magupalli, J Ruan, Q Yin, MK Atianand, MR Vos, GF Schröder, ... Cell 156 (6), 1193-1206, 2014 | 1044 | 2014 |
Molecular basis of NF-κB signaling J Napetschnig, H Wu Annual review of biophysics 42, 443-468, 2013 | 963 | 2013 |
Distinct molecular mechanism for initiating TRAF6 signalling H Ye, JR Arron, B Lamothe, M Cirilli, T Kobayashi, NK Shevde, D Segal, ... Nature 418 (6896), 443-447, 2002 | 770 | 2002 |
The pore-forming protein gasdermin D regulates interleukin-1 secretion from living macrophages CL Evavold, J Ruan, Y Tan, S Xia, H Wu, JC Kagan Immunity 48 (1), 35-44. e6, 2018 | 768 | 2018 |
Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain Y Huang, YC Park, RL Rich, D Segal, DG Myszka, H Wu Cell 104 (5), 781-790, 2001 | 728 | 2001 |
All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction JY Chung, YC Park, H Ye, H Wu Journal of cell science 115 (4), 679-688, 2002 | 720 | 2002 |
The three-dimensional structure of canine parvovirus and its functional implications J Tsao, MS Chapman, M Agbandje, W Keller, K Smith, H Wu, M Luo, ... Science 251 (5000), 1456-1464, 1991 | 637 | 1991 |
Gasdermin E suppresses tumour growth by activating anti-tumour immunity Z Zhang, Y Zhang, S Xia, Q Kong, S Li, X Liu, C Junqueira, KF Meza-Sosa, ... Nature 579 (7799), 415-420, 2020 | 625 | 2020 |
Structure of human chorionic gonadotropin at 2.6 Å resolution from MAD analysis of the selenomethionyl protein H Wu, JW Lustbader, Y Liu, RE Canfield, WA Hendrickson Structure 2 (6), 545-558, 1994 | 588 | 1994 |
The death domain superfamily in intracellular signaling of apoptosis and inflammation HH Park, YC Lo, SC Lin, L Wang, JK Yang, H Wu Annu. Rev. Immunol. 25, 561-586, 2007 | 560 | 2007 |
Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death P Orning, D Weng, K Starheim, D Ratner, Z Best, B Lee, A Brooks, S Xia, ... Science 362 (6418), 1064-1069, 2018 | 539 | 2018 |
DNA binding is required for the apoptogenic action of apoptosis inducing factor H Ye, C Cande, NC Stephanou, S Jiang, S Gurbuxani, N Larochette, ... Nature structural biology 9 (9), 680-684, 2002 | 452 | 2002 |
Microbially produced imidazole propionate impairs insulin signaling through mTORC1 A Koh, A Molinaro, M Ståhlman, MT Khan, C Schmidt, L Mannerås-Holm, ... Cell 175 (4), 947-961. e17, 2018 | 442 | 2018 |
Structural basis for self-association and receptor recognition of human TRAF2 YC Park, V Burkitt, AR Villa, L Tong, H Wu Nature 398 (6727), 533-538, 1999 | 429 | 1999 |
An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells I Zanoni, Y Tan, M Di Gioia, A Broggi, J Ruan, J Shi, CA Donado, F Shao, ... Science 352 (6290), 1232-1236, 2016 | 400 | 2016 |