| Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease T Guo, D Zhang, Y Zeng, TY Huang, H Xu, Y Zhao Molecular neurodegeneration 15, 1-37, 2020 | 647 | 2020 |
| TREM2 is a receptor for β-amyloid that mediates microglial function Y Zhao, X Wu, X Li, LL Jiang, X Gui, Y Liu, Y Sun, B Zhu, JC Piña-Crespo, ... Neuron 97 (5), 1023-1031. e7, 2018 | 603 | 2018 |
| Elevated TREM2 gene dosage reprograms microglia responsivity and ameliorates pathological phenotypes in Alzheimer’s disease models CYD Lee, A Daggett, X Gu, LL Jiang, P Langfelder, X Li, N Wang, Y Zhao, ... Neuron 97 (5), 1032-1048. e5, 2018 | 345 | 2018 |
| Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome X Wang, Y Zhao, X Zhang, H Badie, Y Zhou, Y Mu, LS Loo, L Cai, ... Nature medicine 19 (4), 473-480, 2013 | 254 | 2013 |
| M1 muscarinic acetylcholine receptor in Alzheimer’s disease S Jiang, Y Li, C Zhang, Y Zhao, G Bu, H Xu, YW Zhang Neuroscience bulletin 30, 295-307, 2014 | 173 | 2014 |
| Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy E Barini, O Antico, Y Zhao, F Asta, V Tucci, T Catelani, R Marotta, H Xu, ... Molecular neurodegeneration 11, 1-20, 2016 | 119 | 2016 |
| Appoptosin-mediated caspase cleavage of tau contributes to progressive supranuclear palsy pathogenesis Y Zhao, IC Tseng, CJ Heyser, E Rockenstein, M Mante, A Adame, ... Neuron 87 (5), 963-975, 2015 | 104 | 2015 |
| Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity X Wang, T Huang, Y Zhao, Q Zheng, RC Thompson, G Bu, Y Zhang, ... Cell reports 9 (3), 1023-1033, 2014 | 78 | 2014 |
| Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing Y Zhao, Y Wang, J Yang, X Wang, Y Zhao, X Zhang, Y Zhang Molecular neurodegeneration 7, 1-10, 2012 | 65 | 2012 |
| SNX27 and SORLA interact to reduce amyloidogenic subcellular distribution and processing of amyloid precursor protein TY Huang, Y Zhao, X Li, X Wang, IC Tseng, R Thompson, S Tu, ... Journal of Neuroscience 36 (30), 7996-8011, 2016 | 62 | 2016 |
| ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity B Zhu, LL Jiang, T Huang, Y Zhao, T Liu, Y Zhong, X Li, A Campos, ... Nature Communications 8 (1), 1472, 2017 | 61 | 2017 |
| Inhibition of PKCδ reduces amyloid-β levels and reverses Alzheimer disease phenotypes Y Du, Y Zhao, C Li, Q Zheng, J Tian, Z Li, TY Huang, W Zhang, H Xu Journal of Experimental Medicine 215 (6), 1665-1677, 2018 | 58 | 2018 |
| A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer’s disease P Zhao, Y Xu, LL Jiang, X Fan, L Li, X Li, H Arase, Y Zhao, W Cao, ... Science translational medicine 14 (661), eabq0095, 2022 | 52 | 2022 |
| Membralin deficiency dysregulates astrocytic glutamate homeostasis, leading to ALS-like impairment LL Jiang, B Zhu, Y Zhao, X Li, T Liu, J Pina-Crespo, L Zhou, W Xu, ... The Journal of Clinical Investigation 129 (8), 3103-3120, 2019 | 45 | 2019 |
| SORLA attenuates EphA4 signaling and amyloid β–induced neurodegeneration TY Huang, Y Zhao, L Jiang, X Li, Y Liu, Y Sun, JC Piña-Crespo, B Zhu, ... Journal of Experimental Medicine 214 (12), 3669-3685, 2017 | 45 | 2017 |
| Trisomy 21–induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25 Q Zheng, G Li, S Wang, Y Zhou, K Liu, Y Gao, Y Zhou, L Zheng, L Zhu, ... Science advances 7 (1), eabe1340, 2021 | 43 | 2021 |
| APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients H Zhang, L Shao, Z Lin, QX Long, H Yuan, L Cai, G Jiang, X Guo, R Yang, ... Signal transduction and targeted therapy 7 (1), 261, 2022 | 40 | 2022 |
| SNX27 deletion causes hydrocephalus by impairing ependymal cell differentiation and ciliogenesis X Wang, Y Zhou, J Wang, IC Tseng, T Huang, Y Zhao, Q Zheng, Y Gao, ... Journal of Neuroscience 36 (50), 12586-12597, 2016 | 38 | 2016 |
| APP regulates NGF receptor trafficking and NGF-mediated neuronal differentiation and survival Y Zhang, Y Chen, Y Liu, Y Zhao, FF Liao, H Xu PloS one 8 (11), e80571, 2013 | 37 | 2013 |
| Insufficient ER-stress response causes selective mouse cerebellar granule cell degeneration resembling that seen in congenital disorders of glycosylation L Sun, Y Zhao, K Zhou, HH Freeze, Y Zhang, H Xu Molecular brain 6, 1-8, 2013 | 35 | 2013 |
