| Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay DM Molina, R Jafari, M Ignatushchenko, T Seki, EA Larsson, C Dan, ... Science 341 (6141), 84-87, 2013 | 1801 | 2013 |
| Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay JM Dziekan, H Yu, D Chen, L Dai, G Wirjanata, A Larsson, N Prabhu, ... Science translational medicine 11 (473), eaau3174, 2019 | 190 | 2019 |
| CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil H Almqvist, H Axelsson, R Jafari, C Dan, A Mateus, M Haraldsson, ... Nature communications 7 (1), 11040, 2016 | 159 | 2016 |
| Sculpting nanoparticle dynamics for single-bacteria-level screening and direct binding-efficiency measurement YZ Shi, S Xiong, Y Zhang, LK Chin, YY Chen, JB Zhang, TH Zhang, W Ser, ... Nature communications 9 (1), 815, 2018 | 153 | 2018 |
| Fragment-based ligand design of novel potent inhibitors of tankyrases EA Larsson, A Jansson, FM Ng, SW Then, R Panicker, B Liu, ... Journal of Medicinal Chemistry 56 (11), 4497-4508, 2013 | 84 | 2013 |
| Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality M Kitagawa, PJ Liao, KH Lee, J Wong, SC Shang, N Minami, ... Nature communications 8 (1), 2200, 2017 | 74 | 2017 |
| Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states D Chen, A Jansson, D Sim, A Larsson, P Nordlund Journal of Biological Chemistry 292 (32), 13449-13458, 2017 | 58 | 2017 |
| An efficient proteome-wide strategy for discovery and characterization of cellular nucleotide-protein interactions YT Lim, N Prabhu, L Dai, KD Go, D Chen, L Sreekumar, L Egeblad, ... PLoS One 13 (12), e0208273, 2018 | 51 | 2018 |
| Synthesis of reference standards to enable single cell metabolomic studies of tetramethylrhodamine-labeled ganglioside GM1 EA Larsson, U Olsson, CD Whitmore, R Martins, G Tettamanti, ... Carbohydrate research 342 (3-4), 482-489, 2007 | 45 | 2007 |
| Efficiency of hit generation and structural characterization in fragment-based ligand discovery A Larsson, A Jansson, A Åberg, P Nordlund Current opinion in chemical biology 15 (4), 482-488, 2011 | 44 | 2011 |
| Yoctomole analysis of ganglioside metabolism in PC12 cellular homogenates CD Whitmore, U Olsson, EA Larsson, O Hindsgaul, MM Palcic, NJ Dovichi Electrophoresis 28 (17), 3100-3104, 2007 | 44 | 2007 |
| Proapoptotic cyclic peptide BC71 targets cell-surface GRP78 and functions as an anticancer therapeutic in mice C Kao, R Chandna, A Ghode, C Dsouza, M Chen, A Larsson, SH Lim, ... EBioMedicine 33, 22-32, 2018 | 35 | 2018 |
| Determination of the conformational flexibility of methyl α-cellobioside in solution by NMR spectroscopy and molecular simulations EA Larsson, M Staaf, P Söderman, C Höög, G Widmalm The Journal of Physical Chemistry A 108 (18), 3932-3937, 2004 | 35 | 2004 |
| Predicting allosteric effects from orthosteric binding in Hsp90-ligand interactions: implications for fragment-based drug design A Chandramohan, S Krishnamurthy, A Larsson, P Nordlund, A Jansson, ... PLoS computational biology 12 (6), e1004840, 2016 | 34 | 2016 |
| Structural and immunochemical relationship between the O-antigenic polysaccharides from the enteroaggregative Escherichia coli strain 396/C-1 and Escherichia coli O126 EA Larsson, F Urbina, Z Yang, A Weintraub, G Widmalm Carbohydrate research 339 (8), 1491-1496, 2004 | 34 | 2004 |
| A very simple synthesis of GlcNAc-α-pyrophosphoryl-decanol: A substrate for the assay of a bacterial galactosyltransferase I Brockhausen, EA Larsson, O Hindsgaul Bioorganic & medicinal chemistry letters 18 (2), 804-807, 2008 | 23 | 2008 |
| Analysis of NMR J Couplings in Partially Protected Galactopyranosides EA Larsson, J Ulicny, A Laaksonen, G Widmalm Organic Letters 4 (11), 1831-1834, 2002 | 21 | 2002 |
| Synthesis of the Trifucosylated N‐Linked Hexasaccharide of a Glycoprotein from Haemonchus contortus P Söderman, EA Larsson, G Widmalm European Journal of Organic Chemistry 2002 (10), 1614-1618, 2002 | 9 | 2002 |
| CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil. Nat Commun. 2016; 7: 11040 H Almqvist, H Axelsson, R Jafari, C Dan, A Mateus, M Haraldsson, ... DOI: https://doi. org/10.1038/ncomms11040. PMID: https://www. ncbi. nlm. nih …, 2014 | 7 | 2014 |
| Synthesis of oligosaccharides related to the repeating unit of the capsular polysaccharide from Streptococcus pneumoniae type 37 EA Larsson, M Sjöberg, G Widmalm Carbohydrate research 340 (1), 7-13, 2005 | 6 | 2005 |
Par NordlundKarolinska Institutet在 ki.se 的电子邮件经过验证
