Push–pull perfusion sampling with segmented flow for high temporal and spatial resolution in vivo chemical monitoring TR Slaney, J Nie, ND Hershey, PK Thwar, J Linderman, MA Burns, ... Analytical chemistry 83 (13), 5207-5213, 2011 | 109 | 2011 |
Label free screening of enzyme inhibitors at femtomole scale using segmented flow electrospray ionization mass spectrometry S Sun, TR Slaney, RT Kennedy Analytical chemistry 84 (13), 5794-5800, 2012 | 102 | 2012 |
Mass Spectrometry “Sensor” for in Vivo Acetylcholine Monitoring P Song, ND Hershey, OS Mabrouk, TR Slaney, RT Kennedy Analytical chemistry 84 (11), 4659-4664, 2012 | 94 | 2012 |
Collection of nanoliter microdialysate fractions in plugs for off-line in vivo chemical monitoring with up to 2 s temporal resolution M Wang, T Slaney, O Mabrouk, RT Kennedy Journal of neuroscience methods 190 (1), 39-48, 2010 | 76 | 2010 |
Microfabricated sampling probes for in vivo monitoring of neurotransmitters WH Lee, TR Slaney, RW Hower, RT Kennedy Analytical chemistry 85 (8), 3828-3831, 2013 | 70 | 2013 |
Chemical gradients within brain extracellular space measured using low flow push–pull perfusion sampling in vivo TR Slaney, OS Mabrouk, KA Porter-Stransky, BJ Aragona, RT Kennedy ACS chemical neuroscience 4 (2), 321-329, 2013 | 62 | 2013 |
Unique impacts of methionine oxidation, tryptophan oxidation, and asparagine deamidation on antibody stability and aggregation ME Alam, TR Slaney, L Wu, TK Das, S Kar, GV Barnett, A Leone, ... Journal of Pharmaceutical Sciences 109 (1), 656-669, 2020 | 47 | 2020 |
Enhancing host-cell protein detection in protein therapeutics using HILIC enrichment and proteomic analysis Q Wang, TR Slaney, W Wu, R Ludwig, L Tao, A Leone Analytical Chemistry 92 (15), 10327-10335, 2020 | 32 | 2020 |
Deamidation can compromise antibody colloidal stability and enhance aggregation in a pH-dependent manner ME Alam, GV Barnett, TR Slaney, CG Starr, TK Das, PM Tessier Molecular pharmaceutics 16 (5), 1939-1949, 2019 | 32 | 2019 |
Probing the tryptophan environment in therapeutic proteins: implications for higher order structure on tryptophan oxidation GV Barnett, G Balakrishnan, N Chennamsetty, L Hoffman, J Bongers, ... Journal of Pharmaceutical Sciences 108 (6), 1944-1952, 2019 | 22 | 2019 |
Identification of a host cell protein impurity in therapeutic protein, P1 D Ahluwalia, H Dhillon, T Slaney, H Song, H Boux, S Mehta, L Zhang, ... Journal of pharmaceutical and biomedical analysis 141, 32-38, 2017 | 17 | 2017 |
Ion mobility-mass spectrometry and collision-induced unfolding of designed bispecific antibody therapeutics RC Villafuerte-Vega, HW Li, TR Slaney, N Chennamsetty, G Chen, L Tao, ... Analytical chemistry 95 (17), 6962-6970, 2023 | 12 | 2023 |
Characterization of protein therapeutics by mass spectrometry W Wu, H Song, T Slaney, R Ludwig, L Tao, T Das Protein Analysis Using Mass Spectrometry: Accelerating Protein …, 2017 | 4 | 2017 |
Enzymatic removal of sialic acid enables iCIEF stability monitoring of charge variants of a highly sialylated bispecific antibody BH Peters, J Bautista, TR Slaney, H Guo, RYC Huang, ME Krause, ... Electrophoresis 43 (9-10), 1059-1067, 2022 | 3 | 2022 |
Codon-Directed Determination of the Biological Causes of Sequence Variants in Therapeutic Proteins T Jiang, H Song, TR Slaney, W Wu, E Langsdorf, G Gupta, R Ludwig, ... Analytical chemistry 89 (23), 12749-12755, 2017 | 2 | 2017 |
Low-flow push-pull perfusion for measuring neurotransmitters with high spatial and temporal resolution within the living brain TR Slaney University of Michigan, 2013 | 2 | 2013 |
A comprehensive strategy for the identification of biologics by liquid-chromatography–mass spectrometry for release testing in a regulated environment A Morales, J Candreva, T Jayarathne, AL Esterman, S Voruganti, ... Journal of Pharmaceutical and Biomedical Analysis 234, 115580, 2023 | 1 | 2023 |
Ion Mobility-Mass Spectrometry and Collision-Induced Unfolding Rapidly Characterize the Structural Polydispersity and Stability of an Fc-Fusion Protein RC Villafuerte-Vega, HW Li, AE Bergman, TR Slaney, N Chennamsetty, ... Analytical Chemistry, 2024 | | 2024 |
Screening Clones for Monoclonal Antibody Production Using Droplet Microfluidics Interfaced to Electrospray Ionization Mass Spectrometry CI D’Amico, G Robbins, I Po, Z Fang, TR Slaney, G Tremml, L Tao, ... Journal of the American Society for Mass Spectrometry 34 (6), 1117-1124, 2023 | | 2023 |
Ceramic hydroxyapatite chromatography plays a critical role in bispecific antibody purification process for impurity removal JA Waller, J Zheng, R Dyer, T Slaney, W Wu, L Tao, S Ghose Antibody Therapeutics 6 (1), 30-37, 2023 | | 2023 |