An overview of the serpin superfamily RH Law, Q Zhang, S McGowan, AM Buckle, GA Silverman, W Wong, ... Genome Biol 7 (5), 216, 2006 | 870 | 2006 |
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond WC Van Voorhis, JH Adams, R Adelfio, V Ahyong, MH Akabas, P Alano, ... PLoS Pathog 12 (7), e1005763, 2016 | 298 | 2016 |
Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase S McGowan, CJ Porter, J Lowther, CM Stack, SJ Golding, ... Proceedings of the National Academy of Sciences 106 (8), 2537-2542, 2009 | 180 | 2009 |
Handbook on clostridia P Dürre CRC Press, 2004 | 178 | 2004 |
Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials TS Skinner-Adams, CM Stack, KR Trenholme, CL Brown, J Grembecka, ... Trends in biochemical sciences 35 (1), 53-61, 2010 | 153 | 2010 |
Bestatin-based chemical biology strategy reveals distinct roles for malaria M1-and M17-family aminopeptidases MB Harbut, G Velmourougane, S Dalal, G Reiss, JC Whisstock, O Onder, ... Proceedings of the National Academy of Sciences 108 (34), E526-E534, 2011 | 150 | 2011 |
X-ray crystal structure of the streptococcal specific phage lysin PlyC S McGowan, AM Buckle, MS Mitchell, JT Hoopes, DT Gallagher, ... Proceedings of the National Academy of Sciences 109 (31), 12752-12757, 2012 | 120 | 2012 |
The 1.6 Å crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis CJ Porter, R Schuch, AJ Pelzek, AM Buckle, S McGowan, MCJ Wilce, ... Journal of molecular biology 366 (2), 540-550, 2007 | 112 | 2007 |
Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases S McGowan, CA Oellig, WA Birru, TT Caradoc-Davies, CM Stack, ... Proceedings of the National Academy of Sciences 107 (6), 2449-2454, 2010 | 100 | 2010 |
The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates RM Kennan, W Wong, OP Dhungyel, X Han, D Wong, D Parker, ... PLoS pathogens 6 (11), e1001210, 2010 | 96 | 2010 |
Oxidative Deselenization of Selenocysteine: Applications for Programmed Ligation at Serine LR Malins, NJ Mitchell, S McGowan, RJ Payne Angewandte Chemie 127 (43), 12907-12912, 2015 | 92 | 2015 |
M1 aminopeptidases as drug targets: broad applications or therapeutic niche? N Drinkwater, J Lee, W Yang, TR Malcolm, S McGowan The FEBS Journal, 2017 | 87 | 2017 |
Synthesis of new (−)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase G Velmourougane, MB Harbut, S Dalal, S McGowan, CA Oellig, ... Journal of medicinal chemistry 54 (6), 1655-1666, 2011 | 84 | 2011 |
Fingerprinting the Substrate Specificity of M1 and M17 Aminopeptidases of Human Malaria, Plasmodium falciparum M Poreba, S McGowan, TS Skinner-Adams, KR Trenholme, DL Gardiner, ... PLoS ONE 7 (2), e31938, 2012 | 83 | 2012 |
Catalytic diversity and cell wall binding repeats in the phage encoded endolysins SS Broendum, AM Buckle, S McGowan Molecular microbiology, 2018 | 76 | 2018 |
Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum K Kannan Sivaraman, A Paiardini, M Sieńczyk, C Ruggeri, CA Oellig, ... Journal of Medicinal Chemistry, 2013 | 72 | 2013 |
Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors SN Mistry, N Drinkwater, C Ruggeri, KK Sivaraman, S Loganathan, ... Journal of medicinal chemistry 57 (21), 9168-9183, 2014 | 67 | 2014 |
Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions N Drinkwater, NB Vinh, SN Mistry, RS Bamert, C Ruggeri, JP Holleran, ... European Journal of Medicinal Chemistry, 2016 | 61 | 2016 |
Stonefish toxin defines an ancient branch of the perforin-like superfamily AM Ellisdon, CF Reboul, S Panjikar, K Huynh, CA Oellig, KL Winter, ... Proceedings of the National Academy of Sciences 112 (50), 15360-15365, 2015 | 60 | 2015 |
Federated repositories of X-ray diffraction images S Androulakis, J Schmidberger, MA Bate, R DeGori, A Beitz, C Keong, ... Acta Crystallographica Section D: Biological Crystallography 64 (7), 810-814, 2008 | 59 | 2008 |