| The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist VP Jaakola, MT Griffith, MA Hanson, V Cherezov, EYT Chien, JR Lane, ... Science 322 (5905), 1211-1217, 2008 | 2244 | 2008 |
| A specific cholesterol binding site is established by the 2.8 Å structure of the human β2-adrenergic receptor MA Hanson, V Cherezov, MT Griffith, CB Roth, VP Jaakola, EYT Chien, ... Structure 16 (6), 897-905, 2008 | 1144 | 2008 |
| Structure-Based Discovery of Novel Chemotypes for Adenosine A2A Receptor Antagonists V Katritch, VP Jaakola, JR Lane, J Lin, AP IJzerman, M Yeager, I Kufareva, ... Journal of medicinal chemistry 53 (4), 1799-1809, 2010 | 294 | 2010 |
| Structure of complement factor H carboxyl‐terminus reveals molecular basis of atypical haemolytic uremic syndrome TS Jokiranta, VP Jaakola, MJ Lehtinen, M Pärepalo, S Meri, A Goldman The EMBO journal 25 (8), 1784-1794, 2006 | 186 | 2006 |
| Designing facial amphiphiles for the stabilization of integral membrane proteins Q Zhang, X Ma, A Ward, WX Hong, VP Jaakola, RC Stevens, MG Finn, ... ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH- 46 (37), 7023, 2007 | 136 | 2007 |
| Ligand binding and subtype selectivity of the human A2A adenosine receptor: identification and characterization of essential amino acid residues VP Jaakola, JR Lane, JY Lin, V Katritch, AP IJzerman, RC Stevens Journal of Biological Chemistry 285 (17), 13032-13044, 2010 | 110 | 2010 |
| Structural features of adenosine receptors: from crystal to function H Piirainen, Y Ashok, RT Nanekar, VP Jaakola Biochimica et Biophysica Acta (BBA)-Biomembranes 1808 (5), 1233-1244, 2011 | 85 | 2011 |
| The crystallographic structure of the human adenosine A2A receptor in a high-affinity antagonist-bound state: implications for GPCR drug screening and design VP Jaakola, AP IJzerman Current opinion in structural biology 20 (4), 401-414, 2010 | 66 | 2010 |
| Structural basis of species-selective antagonist binding to the succinate receptor M Haffke, D Fehlmann, G Rummel, J Boivineau, M Duckely, ... Nature 574 (7779), 581-585, 2019 | 64 | 2019 |
| G protein-coupled receptors show unusual patterns of intrinsic unfolding VP Jaakola, J Prilusky, JL Sussman, A Goldman Protein Engineering Design and Selection 18 (2), 103-110, 2005 | 62 | 2005 |
| Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression MA Hanson, A Brooun, KA Baker, VP Jaakola, C Roth, EYT Chien, ... Protein expression and purification 56 (1), 85-92, 2007 | 53 | 2007 |
| Functional reconstitution of human equilibrative nucleoside transporter-1 into styrene maleic acid co-polymer lipid particles S Rehan, VO Paavilainen, VP Jaakola Biochimica et Biophysica Acta (BBA)-Biomembranes 1859 (5), 1059-1065, 2017 | 42 | 2017 |
| Defining thermostability of membrane proteins by western blotting Y Ashok, R Nanekar, VP Jaakola Protein Engineering, Design & Selection 28 (12), 539-542, 2015 | 40 | 2015 |
| Functional studies with membrane-bound and detergent-solubilized α2-adrenergic receptors expressed in Sf9 cells S Sen, VP Jaakola, P Pirilä, M Finel, A Goldman Biochimica et Biophysica Acta (BBA)-Biomembranes 1712 (1), 62-70, 2005 | 33 | 2005 |
| Reindeer β-lactoglobulin crystal structure with pseudo-body-centred noncrystallographic symmetry E Oksanen, VP Jaakola, T Tolonen, K Valkonen, B Åkerström, ... Acta Crystallographica Section D: Biological Crystallography 62 (11), 1369-1374, 2006 | 31 | 2006 |
| Expression, purification and functional characterization of human equilibrative nucleoside transporter subtype-1 (hENT1) protein from Sf9 insect cells S Rehan, VP Jaakola Protein expression and purification 114, 99-107, 2015 | 30 | 2015 |
| Functional expression and direct visualization of the human α2B-adrenergic receptor and α2B-AR-green fluorescent fusion protein in mammalian cell using Semliki Forest virus vectors S Sen, VP Jaakola, H Heimo, M Engström, P Larjomaa, M Scheinin, ... Protein expression and purification 32 (2), 265-275, 2003 | 30 | 2003 |
| Baculovirus-mediated expression of GPCRs in insect cells T Saarenpää, VP Jaakola, A Goldman Methods in enzymology 556, 185-218, 2015 | 28 | 2015 |
| Human adenosine A2A receptor binds calmodulin with high affinity in a calcium-dependent manner H Piirainen, M Hellman, H Tossavainen, P Permi, P Kursula, VP Jaakola Biophysical journal 108 (4), 903-917, 2015 | 24 | 2015 |
| Accelerating GPCR drug discovery with conformation-stabilizing VHHs T Laeremans, ZA Sands, P Claes, A De Blieck, S De Cesco, S Triest, ... Frontiers in Molecular Biosciences 9, 863099, 2022 | 22 | 2022 |
