| Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect-comprehensive overview of clinical trials B Wiśniowska, Z Tylutki, G Wyszogrodzka, S Polak BMC Pharmacology and Toxicology 17 (1), 12, 2016 | 102 | 2016 |
| Top-down, Bottom-up and Middle-out Strategies for Drug Cardiac Safety Assessment via Modeling and Simulations Z Tylutki, B Wiśniowska, S Polak Current pharmacology reports 2 (4), 171-177, 2016 | 37 | 2016 |
| Better prediction of the local concentration–effect relationship: the role of physiologically based pharmacokinetics and quantitative systems pharmacology and toxicology in the … S Polak, Z Tylutki, M Holbrook, B Wiśniowska Drug discovery today 24 (7), 1344-1354, 2019 | 25 | 2019 |
| A four-compartment PBPK heart model accounting for cardiac metabolism-model development and application Z Tylutki, S Polak Scientific reports 7 (1), 39494, 2017 | 18 | 2017 |
| Plasma vs heart tissue concentration in humans–literature data analysis of drugs distribution Z Tylutki, S Polak Biopharmaceutics & Drug Disposition 36 (6), 337-351, 2015 | 17 | 2015 |
| Physiologically based pharmacokinetic-quantitative systems toxicology and safety (PBPK-QSTS) modeling approach applied to predict the variability of amitriptyline … Z Tylutki, A Mendyk, S Polak Journal of Pharmacokinetics and Pharmacodynamics 45, 663-677, 2018 | 10 | 2018 |
| Mechanistic physiologically based pharmacokinetic (PBPK) model of the heart accounting for inter-individual variability: development and performance verification Z Tylutki, A Mendyk, S Polak Journal of Pharmaceutical Sciences 107 (4), 1167-1177, 2018 | 9 | 2018 |
| Humans vary, so cardiac models should account for that too! B Wiśniowska, Z Tylutki, S Polak Frontiers in Physiology 8, 700, 2017 | 7 | 2017 |
| Abnormal olanzapine toxicokinetic profiles–population pharmacokinetic analysis Z Tylutki, W Jawień, K Ciszowski, J Wilimowska, JS Anand Toxicology Mechanisms and Methods 25 (1), 1-12, 2015 | 7 | 2015 |
| Thorough QT (TQT) studies: concordance with torsadogenesis and an evolving cardiac safety testing paradigm B Wiśniowska, Z Tylutki, S Polak Drug Discovery Today 22 (10), 1460-1465, 2017 | 6 | 2017 |
| An open-access dataset of thorough QT studies results B Wiśniowska, Z Tylutki, S Polak Data 5 (1), 10, 2020 | 4 | 2020 |
| CardiacPBPK: a tool for the prediction and visualization of time-concentration profiles of drugs in heart tissue Z Tylutki, J Szlęk, S Polak Computers in Biology and Medicine 115, 103484, 2019 | 4 | 2019 |
| Model of the distribution of diastolic left ventricular posterior wall thickness in healthy adults and its impact on the behavior of a string of virtual cardiomyocytes K Fijorek, FC Tanner, BE Stähli, G Gielerak, P Krzesinski, ... Journal of Cardiovascular Translational Research 7, 507-517, 2014 | 4 | 2014 |
| The database for in silico cardiac risk prediction tools B Wiśniowska, Z Tylutki, S Polak Journal of Pharmacological and Toxicological Methods 105, 106810, 2020 | 1 | 2020 |
| Utilization of physiologically based pharmacokinetic modeling to assess dermal uptake of bisphenol A (BPA) and its skin and systemic exposure in humans B Wisniowska, S Linke, R Pirow, A Luch, Z Tylutki, S Polak INTERNATIONAL JOURNAL OF TOXICOLOGY 39 (1), 62-62, 2020 | 1 | 2020 |
| A heart compartmental model for the prediction of cardiac amitriptyline concentration Z Tylutki, J Jornil, S Polak Journal of Pharmacological and Toxicological Methods 100 (81), 352, 2016 | 1 | 2016 |
| Badanie anomalnych profili toksykokinetycznych metodami farmakokinetyki populacyjnej. Z Tylutki | | 2020 |
| Opracowanie farmakokinetycznego modelu serca służącego do wyznaczania surogatu frakcji aktywnej leku Z Tylutki Jagiellonian University. Medical College. Faculty of Pharmacy. Department of …, 2018 | | 2018 |
| Development and performance verification of the pharmacokinetic model towards determination of the active drug fraction surrogate in the heart tissue Z Tylutki Jagiellonian University. Medical College. Faculty of Pharmacy. Department of …, 2018 | | 2018 |
| The effect of increasing amitriptyline doses on cardiomyocytes’ electrophysiology–simulation study Z Tylutki, J Jornil, S Polak Bio-Algorithms and Med-Systems 12 (1), 33-38, 2016 | | 2016 |
