Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB DL Medina, S Di Paola, I Peluso, A Armani, D De Stefani, R Venditti, ... Nature cell biology 17 (3), 288-299, 2015 | 1240 | 2015 |
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function S Gerndt, CC Chen, YK Chao, Y Yuan, S Burgstaller, A Scotto Rosato, ... Elife 9, e54712, 2020 | 146 | 2020 |
TRPML1: The Ca (2+) retaker of the lysosome S Di Paola, A Scotto-Rosato, DL Medina Cell calcium 69, 112-121, 2018 | 143 | 2018 |
TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway A Scotto Rosato, S Montefusco, C Soldati, S Di Paola, A Capuozzo, ... Nature communications 10 (1), 5630, 2019 | 136 | 2019 |
Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells E Plesch, CC Chen, E Butz, A Scotto Rosato, EK Krogsaeter, H Yinan, ... Elife 7, e39720, 2018 | 91 | 2018 |
Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice B Spix, ES Butz, CC Chen, AS Rosato, R Tang, A Jeridi, V Kudrina, ... Nature communications 13 (1), 318, 2022 | 44 | 2022 |
Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2 P Netcharoensirisuk, C Abrahamian, R Tang, CC Chen, AS Rosato, ... Scientific Reports 11 (1), 8515, 2021 | 43 | 2021 |
Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype C Soldati, I Lopez‐Fabuel, LG Wanderlingh, M Garcia‐Macia, ... EMBO molecular medicine 13 (10), e13742, 2021 | 35 | 2021 |
Two-pore and TRPML cation channels: regulators of phagocytosis, autophagy and lysosomal exocytosis AS Rosato, R Tang, C Grimm Pharmacology & Therapeutics 220, 107713, 2021 | 33 | 2021 |
Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors P Rühl, AS Rosato, N Urban, S Gerndt, R Tang, C Abrahamian, C Leser, ... Scientific reports 11 (1), 8313, 2021 | 31 | 2021 |
Fingolimod phosphate inhibits astrocyte inflammatory activity in mucolipidosis IV LD Weinstock, AM Furness, SS Herron, SS Smith, SB Sankar, SG DeRosa, ... Human molecular genetics 27 (15), 2725-2738, 2018 | 28 | 2018 |
TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann–Pick type C1, and Batten disease A Scotto Rosato, EK Krogsaeter, D Jaślan, C Abrahamian, S Montefusco, ... EMBO molecular medicine 14 (9), e15377, 2022 | 27 | 2022 |
Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes Y Yuan, D Jaślan, T Rahman, SR Bolsover, V Arige, LE Wagner, ... Nature communications 13 (1), 4481, 2022 | 19 | 2022 |
TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy? E Krogsaeter, AS Rosato, C Grimm Cell Calcium 103, 102553, 2022 | 16 | 2022 |
Neurodegenerative lysosomal storage disorders: TPC2 comes to the rescue! S Prat Castro, V Kudrina, D Jaślan, J Böck, A Scotto Rosato, C Grimm Cells 11 (18), 2807, 2022 | 9 | 2022 |
579 Prezioso C, Forrester A, Settembre C, Wang W, Gao Q, Xu H, Sandri M, Rizzuto R, De Matteis MA, and 580 Ballabio A DL Medina, S Di Paola, I Peluso, A Armani, D De Stefani, R Venditti, ... Lysosomal calcium signalling regulates autophagy through calcineurin and …, 2015 | 3 | 2015 |
TRPML1 activation ameliorates lysosomal phenotypes in CLN3 deficient retinal pigment epithelial cells D Wünkhaus, R Tang, K Nyame, NN Laqtom, M Schweizer, AS Rosato, ... bioRxiv, 2023.06. 21.545896, 2023 | 1 | 2023 |
TRPML1: Role in Autophagy and Potential Target to Treat Lysosomal Storage Disorders AS Rosato PQDT-Global, 2018 | 1 | 2018 |
The role of endolysosomal ion channels in cancer C Abrahamian, P Netcharoensirisuk, P Ruehl, AS Rosato, R Tang, ... NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 394 (SUPPL 1), S33-S33, 2021 | | 2021 |
Aginist-dependent switching of ion selectivity in a lsosomal ion channel YK Chao, S Gerndt, CC Chen, Y Yuan, AS Rosato, E Krogsaeter, N Urban, ... NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 393 (SUPPL 1), 8-8, 2020 | | 2020 |