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Edmond M Chan
Edmond M Chan
Instructor in Medicine, Harvard Medical School, Dana-Farber Cancer Institute
在 dfci.harvard.edu 的电子邮件经过验证
标题
引用次数
引用次数
年份
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
DA Barbie, P Tamayo, JS Boehm, SY Kim, SE Moody, IF Dunn, ...
Nature 462 (7269), 108-112, 2009
33832009
WRN helicase is a synthetic lethal target in microsatellite unstable cancers
EM Chan, T Shibue, JM McFarland, B Gaeta, M Ghandi, N Dumont, ...
Nature 568 (7753), 551-556, 2019
3272019
Structure and ubiquitination-dependent activation of TANK-binding kinase 1
D Tu, Z Zhu, AY Zhou, C Yun, KE Lee, AV Toms, Y Li, GP Dunn, E Chan, ...
Cell reports 3 (3), 747-758, 2013
2142013
Inhibition of KRAS-Driven Tumorigenicity by Interruption of an Autocrine Cytokine Circuit
Z Zhu, AR Aref, TJ Cohoon, TU Barbie, Y Imamura, S Yang, SE Moody, ...
Cancer discovery 4 (4), 452-465, 2014
2092014
Repeat expansions confer WRN dependence in microsatellite-unstable cancers
N van Wietmarschen, S Sridharan, WJ Nathan, A Tubbs, EM Chan, ...
Nature 586 (7828), 292-298, 2020
1402020
CRISPRmap: Sequencing-free optical pooled screens mapping multi-omic phenotypes in cells and tissue
J Gu, A Iyer, B Wesley, A Taglialatela, G Leuzzi, S Hangai, A Decker, ...
bioRxiv, 2023
52023
Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap
J Gu, A Iyer, B Wesley, A Taglialatela, G Leuzzi, S Hangai, A Decker, ...
Nature Biotechnology, 1-15, 2024
22024
WRN Is a promising synthetic lethal target for cancers with microsatellite instability (MSI)
EM Chan, KJ Foster, AJ Bass
Targeting the DNA Damage Response for Cancer Therapy, 313-328, 2023
22023
WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers
A Bass, E Chan, T Shibue, J McFarland, B Gaeta, M Ghandi, N Dumont, ...
Nature, 2018
12018
PELO is a synthetic lethal target in chromosome 9p21-deleted or MSI cancers
EM Chan, P Borck, N Bick, K Jankovic, I Boyle, L Parker-Burns, K Foster, ...
Cancer Research 84 (6_Supplement), 3364-3364, 2024
2024
Single analyte profiling of the mutational, immune and microbiome landscape in african american colon cancer patients
C Gurjao, E Chan, MJ Lee, S Hangai, R Rabadan, T Korem, H Hibshoosh, ...
Cancer Research 84 (6_Supplement), 994-994, 2024
2024
Therapeutic treatment of microsatellite unstable cancers
F Vazquez, A Bass, T Shibue, E Chan, J Mcfarland, M Ghandi, ...
2019
Abstract LB-048: WRN helicase is a synthetic lethal target in microsatellite unstable cancers
EM Chan, T Shibue, J McFarland, B Gaeta, F Vazquez, AJ Bass
Cancer Research 79 (13_Supplement), LB-048-LB-048, 2019
2019
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