IAP antagonists target cIAP1 to induce TNFα-dependent apoptosis JE Vince, WWL Wong, N Khan, R Feltham, D Chau, AU Ahmed, ... Cell 131 (4), 682-693, 2007 | 1262 | 2007 |
Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction TL Haas, CH Emmerich, B Gerlach, AC Schmukle, SM Cordier, E Rieser, ... Molecular cell 36 (5), 831-844, 2009 | 858 | 2009 |
Pyroptosis versus necroptosis: similarities, differences, and crosstalk D Frank, JE Vince Cell Death & Differentiation 26 (1), 99-114, 2019 | 811 | 2019 |
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL KE Lawlor, N Khan, A Mildenhall, M Gerlic, BA Croker, AA D’Cruz, C Hall, ... Nature communications 6 (1), 6282, 2015 | 613 | 2015 |
RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis JA Rickard, JA O’Donnell, JM Evans, N Lalaoui, AR Poh, TW Rogers, ... Cell 157 (5), 1175-1188, 2014 | 597 | 2014 |
Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation JE Vince, WWL Wong, I Gentle, KE Lawlor, R Allam, L O'Reilly, K Mason, ... Immunity 36 (2), 215-227, 2012 | 523 | 2012 |
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC V Sagulenko, SJ Thygesen, DP Sester, A Idris, JA Cridland, PR Vajjhala, ... Cell Death & Differentiation 20 (9), 1149-1160, 2013 | 500 | 2013 |
The NLRP3 inflammasome in health and disease: the good, the bad and the ugly P Menu, JE Vince Clinical & Experimental Immunology 166 (1), 1-15, 2011 | 436 | 2011 |
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner SA Conos, KW Chen, D De Nardo, H Hara, L Whitehead, G Núñez, ... Proceedings of the National Academy of Sciences 114 (6), E961-E969, 2017 | 400 | 2017 |
TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα JE Vince, D Chau, B Callus, WWL Wong, CJ Hawkins, P Schneider, ... The Journal of cell biology 182 (1), 171-184, 2008 | 272 | 2008 |
TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (TNF) to efficiently activate NF-κB and to prevent TNF-induced apoptosis JE Vince, D Pantaki, R Feltham, PD Mace, SM Cordier, AC Schmukle, ... Journal of Biological Chemistry 284 (51), 35906-35915, 2009 | 267 | 2009 |
Mitochondrial apoptosis is dispensable for NLRP 3 inflammasome activation but non‐apoptotic caspase‐8 is required for inflammasome priming R Allam, KE Lawlor, ECW Yu, AL Mildenhall, DM Moujalled, RS Lewis, ... EMBO reports 15 (9), 982-990, 2014 | 243 | 2014 |
The pathogen Candida albicans hijacks pyroptosis for escape from macrophages N Uwamahoro, J Verma-Gaur, HH Shen, Y Qu, R Lewis, J Lu, K Bambery, ... MBio 5 (2), 10.1128/mbio. 00003-14, 2014 | 198 | 2014 |
Surface determinants of Leishmania parasites and their role in infectivity in the mammalian host T Naderer, JE Vince, MJ McConville Current molecular medicine 4 (6), 649-665, 2004 | 192 | 2004 |
The mitochondrial apoptotic effectors BAX/BAK activate caspase-3 and-7 to trigger NLRP3 inflammasome and caspase-8 driven IL-1β activation JE Vince, D De Nardo, W Gao, AJ Vince, C Hall, K McArthur, D Simpson, ... Cell reports 25 (9), 2339-2353. e4, 2018 | 190 | 2018 |
Oxidative stress and NLRP3-inflammasome activity as significant drivers of diabetic cardiovascular complications: therapeutic implications A Sharma, M Tate, G Mathew, JE Vince, RH Ritchie, JB De Haan Frontiers in physiology 9, 331431, 2018 | 189 | 2018 |
EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation JS Pearson, C Giogha, S Mühlen, U Nachbur, CLL Pham, Y Zhang, ... Nature microbiology 2 (4), 1-10, 2017 | 179 | 2017 |
The intersection of cell death and inflammasome activation JE Vince, J Silke Cellular and Molecular Life Sciences 73, 2349-2367, 2016 | 176 | 2016 |
TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1 DM Moujalled, WD Cook, T Okamoto, J Murphy, KE Lawlor, JE Vince, ... Cell death & disease 4 (1), e465-e465, 2013 | 176 | 2013 |
Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies SM Condon, Y Mitsuuchi, Y Deng, MG LaPorte, SR Rippin, T Haimowitz, ... Journal of medicinal chemistry 57 (9), 3666-3677, 2014 | 175 | 2014 |