| Crossing enhanced and high fidelity SpCas9 nucleases to optimize specificity and cleavage PI Kulcsár, A Tálas, K Huszár, Z Ligeti, E Tóth, N Weinhardt, E Fodor, ... Genome biology 18, 1-17, 2017 | 137 | 2017 |
| Improved LbCas12a variants with altered PAM specificities further broaden the genome targeting range of Cas12a nucleases E Toth, E Varga, PI Kulcsár, V Kocsis-Jutka, SL Krausz, A Nyeste, ... Nucleic acids research 48 (7), 3722-3733, 2020 | 103 | 2020 |
| Mb-and FnCpf1 nucleases are active in mammalian cells: activities and PAM preferences of four wild-type Cpf1 nucleases and of their altered PAM specificity variants E Tóth, BC Czene, PI Kulcsár, SL Krausz, A Tálas, A Nyeste, É Varga, ... Nucleic acids research 46 (19), 10272-10285, 2018 | 66 | 2018 |
| Cpf1 nucleases demonstrate robust activity to induce DNA modification by exploiting homology directed repair pathways in mammalian cells E Tóth, N Weinhardt, P Bencsura, K Huszár, PI Kulcsár, A Tálas, E Fodor, ... Biology direct 11, 1-14, 2016 | 66 | 2016 |
| Blackjack mutations improve the on-target activities of increased fidelity variants of SpCas9 with 5′ G-extended sgRNAs PI Kulcsár, A Tálas, E Tóth, A Nyeste, Z Ligeti, Z Welker, E Welker Nature communications 11 (1), 1223, 2020 | 40 | 2020 |
| PEAR, a flexible fluorescent reporter for the identification and enrichment of successfully prime edited cells DA Simon, A Tálas, PI Kulcsár, Z Biczók, SL Krausz, G Várady, E Welker Elife 11, e69504, 2022 | 29 | 2022 |
| SuperFi-Cas9 exhibits remarkable fidelity but severely reduced activity yet works effectively with ABE8e PI Kulcsár, A Tálas, Z Ligeti, SL Krausz, E Welker Nature Communications 13 (1), 6858, 2022 | 28* | 2022 |
| A convenient method to pre-screen candidate guide RNAs for CRISPR/Cas9 gene editing by NHEJ-mediated integration of a ‘self-cleaving’GFP-expression plasmid A Tálas, PI Kulcsár, N Weinhardt, A Borsy, E Tóth, K Szebenyi, SL Krausz, ... DNA Research 24 (6), 609-621, 2017 | 28 | 2017 |
| A mixture of amino acids and other small molecules present in the serum suppresses the growth of murine and human tumors in vivo G Kulcsár, D Gaál, PI Kulcsár, Á Schulcz, T Czömpöly International journal of cancer 132 (5), 1213-1221, 2013 | 25 | 2013 |
| Developmentally regulated autophagy is required for eye formation in Drosophila V Billes, T Kovács, A Manzéger, P Lőrincz, S Szincsák, Á Regős, ... Autophagy 14 (9), 1499-1519, 2018 | 24 | 2018 |
| Restriction enzyme body doubles and PCR cloning: on the general use of type IIs restriction enzymes for cloning E Tóth, K Huszár, P Bencsura, PI Kulcsár, B Vodicska, A Nyeste, Z Welker, ... PloS one 9 (3), e90896, 2014 | 20 | 2014 |
| BEAR reveals that increased fidelity variants can successfully reduce the mismatch tolerance of adenine but not cytosine base editors A Tálas, DA Simon, PI Kulcsár, É Varga, SL Krausz, E Welker Nature communications 12 (1), 6353, 2021 | 19 | 2021 |
| The highly conserved, N-terminal (RXXX) 8 motif of mouse Shadoo mediates nuclear accumulation E Tóth, PI Kulcsár, E Fodor, F Ayaydin, L Kalmár, AÉ Borsy, L László, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1833 (5), 1199-1211, 2013 | 13 | 2013 |
| A method for characterizing Cas9 variants via a one-million target sequence library of self-targeting sgRNAs A Tálas, K Huszár, PI Kulcsár, JK Varga, É Varga, E Tóth, Z Welker, ... Nucleic Acids Research 49 (6), e31-e31, 2021 | 12 | 2021 |
| Identification of new interactions between endolysosomal tethering factors Z Simon-Vecsei, Á Sőth, P Lőrincz, A Rubics, A Tálas, PI Kulcsár, ... Journal of Molecular Biology 433 (13), 166965, 2021 | 4 | 2021 |
| A cleavage rule for selection of increased-fidelity SpCas9 variants with high efficiency and no detectable off-targets PI Kulcsár, A Tálas, Z Ligeti, E Tóth, Z Rakvács, Z Bartos, SL Krausz, ... Nature Communications 14 (1), 5746, 2023 | 2* | 2023 |
| Position-dependent sequence motif preferences of SpCas9 are largely determined by scaffold-complementary spacer motifs K Huszár, Z Welker, Z Györgypál, E Tóth, Z Ligeti, PI Kulcsár, J Dancsó, ... Nucleic Acids Research 51 (11), 5847-5863, 2023 | 2 | 2023 |
| Targeted knock-in of NCF1 cDNA into the NCF2 locus leads to myeloid phenotypic correction of p47phox-deficient chronic granulomatous disease KM Siow, M Güngör, D Wrona, F Raimondi, O Pastukhov, P Tsapogas, ... Molecular Therapy-Nucleic Acids 35 (3), 2024 | | 2024 |
| Development of new increased fidelity SpCas9 variants PI Kulcsár szte, 2019 | | 2019 |
