Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders DJ Baker, T Wijshake, T Tchkonia, NK LeBrasseur, BG Childs, ... Nature 479 (7372), 232-236, 2011 | 3813 | 2011 |
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan DJ Baker, BG Childs, M Durik, ME Wijers, CJ Sieben, J Zhong, ... Nature 530 (7589), 184-189, 2016 | 2589 | 2016 |
Cellular senescence in aging and age-related disease: from mechanisms to therapy BG Childs, M Durik, DJ Baker, JM Van Deursen Nature medicine 21 (12), 1424-1435, 2015 | 2082 | 2015 |
Senescent intimal foam cells are deleterious at all stages of atherosclerosis BG Childs, DJ Baker, T Wijshake, CA Conover, J Campisi, ... Science 354 (6311), 472-477, 2016 | 1104 | 2016 |
Senescent cells: an emerging target for diseases of ageing BG Childs, M Gluscevic, DJ Baker, RM Laberge, D Marquess, ... Nature reviews Drug discovery 16 (10), 718-735, 2017 | 1067 | 2017 |
Senescence and apoptosis: dueling or complementary cell fates? BG Childs, DJ Baker, JL Kirkland, J Campisi, JM Van Deursen EMBO reports 15 (11), 1139-1153, 2014 | 941 | 2014 |
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels CCS Chini, TR Peclat, GM Warner, S Kashyap, JM Espindola-Netto, ... Nature metabolism 2 (11), 1284-1304, 2020 | 226 | 2020 |
Senescent cells: a therapeutic target for cardiovascular disease BG Childs, H Li, JM Van Deursen The Journal of clinical investigation 128 (4), 1217-1228, 2018 | 192 | 2018 |
Spartan deficiency causes genomic instability and progeroid phenotypes RS Maskey, MS Kim, DJ Baker, B Childs, LA Malureanu, KB Jeganathan, ... Nature communications 5 (1), 5744, 2014 | 128 | 2014 |
Treatment for osteoarthritis in a joint by administering a means for inhibiting MDM2 RM Laberge, J Campisi, A Davalos, M Demaria, N David, AP Vasserot, ... US Patent 9,993,472, 2018 | 65* | 2018 |
Progressive cellular senescence mediates renal dysfunction in ischemic nephropathy SR Kim, AS Puranik, K Jiang, X Chen, XY Zhu, I Taylor, ... Journal of the American Society of Nephrology 32 (8), 1987-2004, 2021 | 62 | 2021 |
A. Saltness R, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van Deursen JM (2016) Naturally occurring p16 Ink4a-positive cells shorten healthy lifespan DJ Baker, BG Childs, M Durik, ME Wijers, CJ Sieben, J Zhong Nature 530 (7589), 184-189, 0 | 54 | |
Senescent cells suppress innate smooth muscle cell repair functions in atherosclerosis BG Childs, C Zhang, F Shuja, I Sturmlechner, S Trewartha, RF Velasco, ... Nature aging 1 (8), 698-714, 2021 | 43 | 2021 |
Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1 C Cohen, O Le Goff, F Soysouvanh, F Vasseur, M Tanou, C Nguyen, ... EMBO Molecular Medicine 13 (11), e14146, 2021 | 38 | 2021 |
Unit dose of a cis-imidazoline for treating an osteoarthritic joint by removing senescent cells RM Laberge, J Campisi, A Davalos, M Demaria, N David, AP Vasserot, ... US Patent 9,849,128, 2017 | 33* | 2017 |
Cellular identification and quantification of senescence-associated β-galactosidase activity in vivo BG Childs, TJ Bussian, DJ Baker Cellular Senescence: Methods and Protocols, 31-38, 2019 | 23 | 2019 |
Treatment of ophthalmic conditions by selectively removing senescent cells from the eye RM Laberge, J Campisi, M Demaria, N David, AP Vasserot, JL Kirkland, ... US Patent 10,010,546, 2018 | 19 | 2018 |
Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders RM Laberge, J Campisi, A Davalos, M Demaria, N David, AP Vasserot, ... US Patent App. 15/455,630, 2017 | 18 | 2017 |
Treatment for osteoarthritis by intra-articular administration of a cis-imidazoline RM Laberge, J Campisi, A Davalos, M Demaria, N David, AP Vasserot, ... US Patent 9,855,266, 2018 | 16 | 2018 |
Method of optimizing conditions for selectively removing a plurality of senescent cells from a tissue or a mixed cell population RM Laberge, J Campisi, A Davalos, M Demaria, N David, Y Zhu, ... US Patent 10,213,426, 2019 | 15 | 2019 |