New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk J Dupuis, C Langenberg, I Prokopenko, R Saxena, N Soranzo, ... Nature genetics 42 (2), 105-116, 2010 | 2537 | 2010 |
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis BF Voight, LJ Scott, V Steinthorsdottir, AP Morris, C Dina, RP Welch, ... Nature genetics 42 (7), 579-589, 2010 | 2175 | 2010 |
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps A Mahajan, D Taliun, M Thurner, NR Robertson, JM Torres, NW Rayner, ... Nature genetics 50 (11), 1505-1513, 2018 | 1590 | 2018 |
Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6. 2 and permanent neonatal diabetes AL Gloyn, ER Pearson, JF Antcliff, P Proks, GJ Bruining, AS Slingerland, ... New England Journal of Medicine 350 (18), 1838-1849, 2004 | 1456 | 2004 |
The genetic architecture of type 2 diabetes C Fuchsberger, J Flannick, TM Teslovich, A Mahajan, V Agarwala, ... Nature 536 (7614), 41-47, 2016 | 1247 | 2016 |
Large-scale association studies of variants in genes encoding the pancreatic β-cell KATP channel subunits Kir6. 2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant … AL Gloyn, MN Weedon, KR Owen, MJ Turner, BA Knight, G Hitman, ... Diabetes 52 (2), 568-572, 2003 | 1019 | 2003 |
Parental origin of sequence variants associated with complex diseases A Kong, V Steinthorsdottir, G Masson, G Thorleifsson, P Sulem, ... Nature 462 (7275), 868-874, 2009 | 661 | 2009 |
Update on mutations in glucokinase (GCK), which cause maturity‐onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia KK Osbak, K Colclough, C Saint‐Martin, NL Beer, C Bellanné‐Chantelot, ... Human mutation 30 (11), 1512-1526, 2009 | 591 | 2009 |
Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants L Pasquali, KJ Gaulton, SA Rodríguez-Seguí, L Mularoni, ... Nature genetics 46 (2), 136-143, 2014 | 572 | 2014 |
Mutations in PTF1A cause pancreatic and cerebellar agenesis GS Sellick, KT Barker, I Stolte-Dijkstra, C Fleischmann, R J Coleman, ... Nature genetics 36 (12), 1301-1305, 2004 | 512 | 2004 |
Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes I Morán, I Akerman, M Van De Bunt, R Xie, M Benazra, T Nammo, L Arnes, ... Cell metabolism 16 (4), 435-448, 2012 | 488 | 2012 |
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes RJ Strawbridge, J Dupuis, I Prokopenko, A Barker, E Ahlqvist, D Rybin, ... Diabetes 60 (10), 2624-2634, 2011 | 456 | 2011 |
Permanent Neonatal Diabetes due to Mutations in KCNJ11 Encoding Kir6.2: Patient Characteristics and Initial Response to Sulfonylurea Therapy JV Sagen, H Ræder, E Hathout, N Shehadeh, K Gudmundsson, H Bævre, ... Diabetes 53 (10), 2713-2718, 2004 | 455 | 2004 |
Mutations in ATP-sensitive K+ channel genes cause transient neonatal diabetes and permanent diabetes in childhood or adulthood SE Flanagan, AM Patch, DJG Mackay, EL Edghill, AL Gloyn, D Robinson, ... Diabetes 56 (7), 1930-1937, 2007 | 447 | 2007 |
The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in … NL Beer, ND Tribble, LJ McCulloch, C Roos, PRV Johnson, ... Human molecular genetics 18 (21), 4081-4088, 2009 | 436 | 2009 |
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci KJ Gaulton, T Ferreira, Y Lee, A Raimondo, R Mägi, ME Reschen, ... Nature genetics 47 (12), 1415-1425, 2015 | 417 | 2015 |
The trans-ancestral genomic architecture of glycemic traits J Chen, CN Spracklen, G Marenne, A Varshney, LJ Corbin, J Luan, ... Nature genetics 53 (6), 840-860, 2021 | 402 | 2021 |
Glucokinase (GCK) mutations in hyper‐ and hypoglycemia: Maturity‐onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy AL Gloyn Human mutation 22 (5), 353-362, 2003 | 364 | 2003 |
Global microRNA expression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes BM Herrera, HE Lockstone, JM Taylor, M Ria, A Barrett, S Collins, ... Diabetologia 53, 1099-1109, 2010 | 352 | 2010 |
Identification of type 2 diabetes loci in 433,540 East Asian individuals CN Spracklen, M Horikoshi, YJ Kim, K Lin, F Bragg, S Moon, K Suzuki, ... Nature 582 (7811), 240-245, 2020 | 346 | 2020 |