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Alyssa Winkler
Alyssa Winkler
PhD Candidate in Chemical Biology
在 umich.edu 的电子邮件经过验证
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Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain
S Shukla, W Ying, F Gray, Y Yao, ML Simes, Q Zhao, H Miao, HJ Cho, ...
Nature chemical biology 17 (7), 784-793, 2021
472021
Identification of thiourea-based inhibitors of the B-cell lymphoma 6 BTB domain via NMR-based fragment screening and computer-aided drug design
H Cheng, BM Linhares, W Yu, MG Cardenas, Y Ai, W Jiang, A Winkler, ...
Journal of medicinal chemistry 61 (17), 7573-7588, 2018
442018
Development of potent dimeric inhibitors of GAS41 YEATS domain
D Listunov, BM Linhares, EG Kim, A Winkler, ML Simes, S Weaver, ...
Cell Chemical Biology 28 (12), 1716-1727. e6, 2021
192021
Molecular investigation of the tandem Tudor domain and plant homeodomain histone binding domains of the epigenetic regulator UHRF2
SM Ginnard, AE Winkler, C Mellado Fritz, T Bluhm, R Kemmer, M Gilliam, ...
Proteins: Structure, Function, and Bioinformatics 90 (3), 835-847, 2022
52022
MRG15 activates histone methyltransferase activity of ASH1L by recruiting it to the nucleosomes
S Al-Harthi, H Li, A Winkler, K Szczepski, J Deng, J Grembecka, ...
Structure 31 (10), 1200-1207. e5, 2023
42023
Targeting the GAS41 YEATS domain in non-small cell lung cancer with novel small molecules
A Winkler, D Listunov, B Linhares, J Ray, S Weaver, S Zolov, ...
Cancer Research 84 (6_Supplement), 3239-3239, 2024
2024
GAS41 inhibitors and methods of use thereof
A Winkler, B Linhares, D Listunov, J Grembecka, T Cierpicki, EG Kim
US Patent 11,858,925, 2024
2024
Targeting Polycomb Repressive Complex 1 with small-molecule inhibitors as a potential therapeutic approach to combat leukemia
ML Simes, Y Yao, SR Park, T Purohit, H Miao, X Zhang, W Ying, F Gray, ...
Cancer Research 83 (7_Supplement), 6286-6286, 2023
2023
H3K9me3 binding analysis of the isolated PHD and TTD domains of UHRF2
I Miller, P Khuansanguan, S Ginnard, A Winkler, D Heyl, R Trievel
The FASEB Journal 36, 2022
2022
Molecular investigation of the TTD and PHD histone binding domains of the epigenetic regulator UHRF2
BN Albaugh, S Ginnard, A Winkler, C Mellado Fritz, R Kemmer, T Bluhm, ...
The FASEB Journal 36, 2022
2022
Molecular investigation of the TTD and PHD histone binding domains of the epigenetic regulator UHRF2.
SM Ginnard, AE Winkler, CM Fritz, T Bluhm, R Kemmer, M Gilliam, ...
Proteins, 2021
2021
Molecular Characterization of UHRF1 and UHRF2
A Winkler, B Albaugh
The FASEB Journal 31, 755.11-755.11, 2017
2017
Effect of a bulky substituent on the stereoselectivity of a reaction leading to acylpyrrolidines
A Winkler, MC Milletti
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 248, 2014
2014
Substituent effects in a Lewis acid catalyzed aza-Cope Mannich tandem reaction
A Winkler, MC Milletti
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 244, 2012
2012
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